Patent US5756632A successfully refreshed from Google Patents.
US5756632A
Expired / Lapsed
US
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Systems for premeating molecules of predetermined molecular weight range
Assignee: DSM Biomedical Inc
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Filing: 1995-06-02
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Granted: 1998-05-26
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Expires: 2015-06-02
Abstract
Abstract A biocompatible, hydrophilic, segmented block polyurethane copolymer which comprises 5 to 45 wt % of a hard segment and 95 to 55 wt % of a soft segment selected from a hydrophilic, hydrophobic and amphipathic oligomer is disclosed. The copolymer is capable of forming a non-porous, semi-permeable film of a tensile strength greater than 300 and up to 10,000 psi, and has an ultimate elongation greater than 300% and up to 1,500% and a water absorption such that the sum of the volume fraction of absorbed water and the hydrophilic volume fraction of the soft segment exceeds about 100% and is up to about 2,000% of the dry polymer volume. The film is permeable to cell nutrients and waste molecules of up to about 6,000 to 600,000 molecular weight and is substantially impermeable to cells and particulate matter. A non-porous, semi-permeable, biocompatible film is formed from the block copolymer of the invention in the form of a flexible sheet or a hollow fiber. Also disclosed is a method of permeating molecules of a predetermined molecular weight range while preventing the passage of larger molecular weight molecules, cells, and condensed phases of matter between two fluids comprising interposing between the two fluids the non-porous film of the invention.
Inventors
- 👤 Robert S. Ward
- 👤 Kathleen A. White
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 22:17
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/18; A61L29/00; A61L29/04; A61L29/06; A61L31/00; A61L31/04; A61L31/06; A61L33/00; A61L33/06; A61L33/068; B; B01; B01D; B01D69/00; B01D69/08; B01D71/00; B01D71/06; B01D71/38; B01D71/381; B01D71/54; B01D71/58; B01D71/60; B01D71/76; B01D71/80; C; C07; C07K; C07K1/00; C07K1/14; C07K1/34; C08; C08G; C08G18/00; C08G18/06; C08G18/08; C08G18/10; C08G18/12; C08G18/28; C08G18/2805; C08G18/2815; C08G18/283; C08G18/285; C08G18/2865; C08G18/288; C08G18/2885; C08G18/289; C08G18/40; C08G18/42; C08G18/44; C08G18/48; C08G18/4804; C08G18/4808; C08G18/4833; C08G18/4854; C08G18/65; C08G18/66; C08G18/6666; C08G18/667; C08G18/6674; C08G18/6681; C08G18/6685; C12; C12N; C12N11/00; C12N11/02; C12N11/08; C12N11/089; C12N11/093
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
188 words
An article comprising a hydrophilic gel with a water content of at least about 35% substantially enclosed within a membrane comprising a biocompatible, hydrophilic, segmented block polyurethane copolymer comprising about 5 to 45 wt % of at least one hard segment; and about 95 to 55 wt % of at least one soft segments comprising at least one hydrophilic, hydrophobic or amphipathic oligomer selected from the group consisting of aliphatic polyols, aliphatic and aromatic polyamines and mixtures thereof; the copolymer being capable of forming a substantially non-porous semi-permeable film having a tensile strength greater than about 350 psi and up to about 10,000 psi, an ultimate elongation greater than about 300% and up to about 1,500% and a water absorption such that the sum of the volume fraction of absorbed water and the hydrophilic volume fraction of the soft segment exceeds about 100% and up to about 2,000% of the dry polymer volume and exceeds about 50% and up to about 95% of the wet polymer volume and being permeable to monodisperse molecules of up to about 6,000 to 600,000 molecular weight and substantially impermeable to particulate matter.
Claim 2
Dependent Claim
188 words
An article comprising a hydrophilic gel with a water content of at least about 35% substantially enclosed within a membrane comprising a biocompatible, hydrophilic, segmented block polyurethane copolymer comprising about 5 to 45 wt % of at least one hard segment; and about 95 to 55 wt % of at least one soft segments comprising at least one hydrophilic, hydrophobic or amphipathic oligomer selected from the group consisting of aliphatic polyols, aliphatic and aromatic polyamines and mixtures thereof; the copolymer being capable of forming a substantially non-porous semi-permeable film having a tensile strength greater than about 350 psi and up to about 10,000 psi, an ultimate elongation greater than about 300% and up to about 1,500% and a water absorption such that the sum of the volume fraction of absorbed water and the hydrophilic volume fraction of the soft segment exceeds about 100% and up to about 2,000% of the dry polymer volume and exceeds about 50% and up to about 95% of the wet polymer volume and being permeable to monodisperse molecules of up to about 6,000 to 600,000 molecular weight and substantially impermeable to particulate matter.
Claim 3
Dependent Claim
201 words
An article comprising a hydrophilic gel with a water content of at least about 35% substantially enclosed within a membrane comprising a biocompatible, hydrophilic, segmented block polyurethane copolymer having a number average molecular weight of about 5,000 to 150,000, said copolymer comprising about 5 to 45 wt % of at least one hard segment; and about 95 to 55 wt % of at least one soft segments comprising at least one hydrophilic, hydrophobic or amphipathic oligomer selected from the group consisting of aliphatic polyols, aliphatic and aromatic polyamines and mixtures thereof; the copolymer being capable of forming a substantially non-porous semi-permeable film having a tensile strength greater than about 350 psi and up to about 10,000 psi, an ultimate elongation greater than about 300% and up to about 1,500% and a water absorption such that the sum of the volume fraction of absorbed water and the hydrophilic volume fraction of the soft segment exceeds about 100% and up to about 2,000% of the dry polymer volume and exceeds about 50% and up to about 95% of the wet polymer volume and being permeable to monodisperse molecules of up to about 6,000 to 600,000 molecular weight and substantially impermeable to particulate matter.
Claim 4
Dependent Claim
201 words
An article comprising a hydrophilic gel with a water content of at least about 35% substantially enclosed within a membrane comprising a biocompatible, hydrophilic, segmented block polyurethane copolymer having a number average molecular weight of about 5,000 to 150,000, said copolymer comprising about 5 to 45 wt % of at least one hard segment; and about 95 to 55 wt % of at least one soft segments comprising at least one hydrophilic, hydrophobic or amphipathic oligomer selected from the group consisting of aliphatic polyols, aliphatic and aromatic polyamines and mixtures thereof; the copolymer being capable of forming a substantially non-porous semi-permeable film having a tensile strength greater than about 350 psi and up to about 10,000 psi, an ultimate elongation greater than about 300% and up to about 1,500% and a water absorption such that the sum of the volume fraction of absorbed water and the hydrophilic volume fraction of the soft segment exceeds about 100% and up to about 2,000% of the dry polymer volume and exceeds about 50% and up to about 95% of the wet polymer volume and being permeable to monodisperse molecules of up to about 6,000 to 600,000 molecular weight and substantially impermeable to particulate matter.
Claim 5
Dependent Claim
15 words
An article as in claim 2 wherein said hydrophilic gel contains at least 90% water.
Claim 6
Dependent Claim
45 words
An article as in claim 3 in which said hydrophilic gel is a hydrogel selected from the group consisting of alginates, guar gums, gum tragacanths, locust bean gums, methocels, xanthan gums, polyethylene oxides, polypropylene oxides, dextrans, acrylates, methacrylates, polyvinyl alcohols, polyvinyl pyrrolidones, and mixtures thereof.
Claim 7
Dependent Claim
127 words
An article as in claim 2 in which said copolymer has a number average molecular weight of about 5,000 to 150,000, and comprises about 5 to 45% of at least one hard segment selected from the group consisting of reaction products of an organic diisocyanate and a polyamine and a polyol; and about 95 to 55 wt % of a hydrophilic soft segment comprising a blend of a polyethyleneoxide-polytetramethyleneoxide copolymer and a polyethyleneoxide homopolymer; about 5 to 45 wt % of a least one hard segment selected from the group consisting of reaction products of an organic diisocyanate and a polyamine and a polyol; and about 95 to 55 wt % of a hydrophilic soft segment comprising a blend of polyethyleneoxide-polytetramethyleneoxide copolymer and a polyethyleneoxide-polypropylene oxide copolymer.
Claim 8
Dependent Claim
75 words
An article as in claim 2 in which said copolymer has a number average molecular weight of about 5,000 to 150,000, and comprises about 5 to 45 wt % of at least one hard segment selected from the group consisting of reaction products of an organic diisocyanate and a polyamine and a polyol; and about 95 to 55 wt % of a soft segment comprising a blend of a polyethyleneoxide-homopolymer and a polyethyleneoxide-polypropylene oxide copolymer.
Claim 9
Independent Claim
216 words
A method of permeating molecules of a predetermined molecular weight range while substantially preventing the passage of cells and particulate matter between two fluids comprising interposing between the two fluids a non-porous, semi-permeable, biocompatible film comprising a biocompatible, hydrophilic, segmented block polyurethane copolymer having a number average molecular weight of about 5,000 to 150,000, said copolymer comprising about 5 to 45 wt % of at least one hard segment; and about 95 to 55 wt % of at least one soft segments comprising at least one hydrophilic, hydrophobic or amphipatic oligomer selected from the group consisting of aliphatic polyols, aliphatic and aromatic polyamines and mixtures thereof; the copolymer being capable of forming a substantially non-porous semi-permeable film having a tensile strength greater than about 350 psi and up to about 10,000 psi, an ultimate elongation greater than about 300% and up to about 1,500% and a water absorption such that the sum of the volume fraction of absorbed water and the hydrophilic volume fraction of the soft segment exceeds about 100% and up to about 2,000% of the dry polymer volume and exceeds about 50% and up to about 95% of the wet polymer volume and being permeable to monodisperse molecules of up to about 6,000 to 600,000 molecular weight and substantially impermeable to particulate matter.
Claim 10
Independent Claim
216 words
A method of permeating molecules of a predetermined molecular weight range while substantially preventing the passage of cells and particulate matter between two fluids comprising interposing between the two fluids a non-porous, semi-permeable, biocompatible film comprising a biocompatible, hydrophilic, segmented block polyurethane copolymer having a number average molecular weight of about 5,000 to 150,000, said copolymer comprising about 5 to 45 wt % of at least one hard segment; and about 95 to 55 wt % of at least one soft segments comprising at least one hydrophilic, hydrophobic or amphipatic oligomer selected from the group consisting of aliphatic polyols, aliphatic and aromatic polyamines and mixtures thereof; the copolymer being capable of forming a substantially non-porous semi-permeable film having a tensile strength greater than about 350 psi and up to about 10,000 psi, an ultimate elongation greater than about 300% and up to about 1,500% and a water absorption such that the sum of the volume fraction of absorbed water and the hydrophilic volume fraction of the soft segment exceeds about 100% and up to about 2,000% of the dry polymer volume and exceeds about 50% and up to about 95% of the wet polymer volume and being permeable to monodisperse molecules of up to about 6,000 to 600,000 molecular weight and substantially impermeable to particulate matter.
Claim 11
Dependent Claim
28 words
The method of claim 7 wherein the molecules that are permeated are selected from the group consisting of glucose, angiotensin I, glucagon, insulin, aprotinin, albumin, IgG, and oxygen.
Claim 12
Dependent Claim
15 words
The method of claim 7 wherein the film is in the form of hollow fibers.
References Cited (Backward Citations)
US4377010A
Cited
US5116371A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-05-25 | 2001-11-24 | 2002-05-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-05-25 | 2005-11-24 | 2006-05-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-05-25 | 2009-11-24 | 2010-05-26 | $7700.00 | Window Closed / Lapsed |