US5731339A
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Methods and formulations for modulating the human sexual response
Assignee: Repros Therapeutics Inc
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Filing: 1995-04-28
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Granted: 1998-03-24
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Expires: 2015-04-28
Abstract
Abstract Improved methods for modulating the human sexual response by orally administering a rapidly dissolving tablet comprising phentolamine mesylate or phentolamine hydrochloride is disclosed.
Inventors
- 👤 Fred Lowrey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 22:27
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K31/138; A61K31/21; A61K31/215; A61K31/22; A61K31/222; A61K31/275; A61K31/277; A61K31/33; A61K31/335; A61K31/34; A61K31/341; A61K31/395; A61K31/41; A61K31/4164; A61K31/417; A61K31/4174; A61K31/435; A61K31/44; A61K31/4406; A61K31/47; A61K31/472; A61K31/475; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/205; A61K9/2054; A61P; A61P13/00; A61P13/02; A61P15/00; A61P15/10; A61P5/00; A61P5/24
Claims Analysis
Total Claims: 48
Claim 1
Independent Claim
29 words
A composition comprising an orally administrable rapidly dissolving tablet comprising phentolamine mesylate in a pharmaceutically acceptable carrier, said tablet having a disintegration time of less than about twenty minutes.
Claim 2
Dependent Claim
29 words
A composition comprising an orally administrable rapidly dissolving tablet comprising phentolamine mesylate in a pharmaceutically acceptable carrier, said tablet having a disintegration time of less than about twenty minutes.
Claim 3
Dependent Claim
19 words
The composition of claim 1 wherein said composition comprises about 5 mg to about 80 mg of phentolamine mesylate.
Claim 4
Dependent Claim
29 words
A composition comprising an orally administrable rapidly dissolving tablet comprising phentolamine hydrochloride in a pharmaceutically acceptable carrier, said tablet having a disintegration time of less than about twenty minutes.
Claim 5
Dependent Claim
29 words
A composition comprising an orally administrable rapidly dissolving tablet comprising phentolamine hydrochloride in a pharmaceutically acceptable carrier, said tablet having a disintegration time of less than about twenty minutes.
Claim 6
Dependent Claim
19 words
The composition of claim 3 wherein said composition comprises about 5 mg to about 80 mg of phentolamine hydrochloride.
Claim 7
Dependent Claim
26 words
The composition of claims 1, 2, 3, or 4 wherein said rapidly dissolving tablet has a disintegration time of about one minute to about ten minutes.
Claim 8
Dependent Claim
23 words
The composition of claims 1, 2, 3, or 4 wherein said rapidly dissolving tablet has a disintegration time of less than one minute.
Claim 9
Dependent Claim
89 words
In a method for modulating sexual response in a human by administering a vasodilator agent to blood circulation in an amount effective to permit increased blood flow to the genitalia, the improvement comprising modulating the sexual response by oral administration of a rapidly dissolving tablet comprising phentolamine mesylate, said tablet having a disintegration time of less than about twenty minutes and being capable of delivering to the blood circulation an amount of phentolamine mesylate effective to permit increased blood flow to the genitalia within about one hour after administration.
Claim 10
Dependent Claim
89 words
In a method for modulating sexual response in a human by administering a vasodilator agent to blood circulation in an amount effective to permit increased blood flow to the genitalia, the improvement comprising modulating the sexual response by oral administration of a rapidly dissolving tablet comprising phentolamine mesylate, said tablet having a disintegration time of less than about twenty minutes and being capable of delivering to the blood circulation an amount of phentolamine mesylate effective to permit increased blood flow to the genitalia within about one hour after administration.
Claim 11
Dependent Claim
41 words
The improvement of claim 7 wherein the amount of phentolamine mesylate effective to increase blood flow to the genitalia is achieved in the blood circulation from about ten minutes to one hour after the oval administration of said rapidly dissolving tablet.
Claim 12
Dependent Claim
27 words
The improvement of claim 7 or 8 wherein the amount of phentolamine mesylate in said rapidly dissolving tablet is from about 5 mg to about 80 mg.
Claim 13
Dependent Claim
23 words
The improvement of claim 9 wherein said rapidly dissolving tablet has a disintegration time of from about one minute to about ten minutes.
Claim 14
Dependent Claim
19 words
The improvement of claim 9 wherein said rapidly dissolving tablet has a disintegration time of less than one minute.
Claim 15
Dependent Claim
90 words
In a method for modulating sexual response in a human by administering a vasodilator agent to blood circulation in an amount effective to permit increased blood flow to the genitalia, the improvement comprising modulating the sexual response by the oral administration of a rapidly dissolving tablet comprising phentolamine hydrochloride, said tablet having a disintegration time of less than about twenty minutes and being capable of delivering to the blood circulation an amount of phentolamine hydrochloride effective to permit increased blood flow to the genitalia within about one hour after administration.
Claim 16
Dependent Claim
90 words
In a method for modulating sexual response in a human by administering a vasodilator agent to blood circulation in an amount effective to permit increased blood flow to the genitalia, the improvement comprising modulating the sexual response by the oral administration of a rapidly dissolving tablet comprising phentolamine hydrochloride, said tablet having a disintegration time of less than about twenty minutes and being capable of delivering to the blood circulation an amount of phentolamine hydrochloride effective to permit increased blood flow to the genitalia within about one hour after administration.
Claim 17
Dependent Claim
41 words
The improvement of claim 12 wherein the amount of phentolamine hydrochloride effective to increase blood flow to the genitalia is achieved in the blood circulation from about ten minutes to one hour after the oral administration of said rapidly dissolving tablet.
Claim 18
Dependent Claim
27 words
The improvement of claim 12 or 13 wherein the amount of phentolamine hydrochloride in said rapidly dissolving tablet is from about 5 mg to about 80 mg.
Claim 19
Dependent Claim
23 words
The improvement of claim 14 wherein said rapidly dissolving tablet has a disintegration time of from about one minute to about ten minutes.
Claim 20
Dependent Claim
19 words
The improvement of claim 14 wherein the rapidly dissolving tablet has a disintegration time of less than one minute.
Claim 21
Dependent Claim
27 words
The improvement of claim 7, 8, 12, or 13 wherein said rapidly dissolving tablet has a disintegration time of from about one minute to about ten minutes.
Claim 22
Dependent Claim
23 words
The improvement of claim 7, 8, 12, or 13 wherein said rapidly dissolving tablet has a disintegration time of less than one minute.
Claim 23
Dependent Claim
13 words
The improvement of claim 7 or 12 wherein the human is a male.
Claim 24
Dependent Claim
13 words
The improvement of claim 7 or 12 wherein the human is a female.
Claim 25
Dependent Claim
88 words
In a method for treating male impotence by administering a vasodilator to blood circulation in an amount effective to permit increased blood flow to the penis thereby improving erectile ability, the improvement comprising permitting increased blood flow to the penis by oral administration of a rapidly dissolving tablet comprising phentolamine mesylate, said tablet having a disintegration time of less than about twenty minutes and being capable of delivering to the blood circulation the amount of phentolamine mesylate effective to improve erectile ability within about one hour after administration.
Claim 26
Dependent Claim
88 words
In a method for treating male impotence by administering a vasodilator to blood circulation in an amount effective to permit increased blood flow to the penis thereby improving erectile ability, the improvement comprising permitting increased blood flow to the penis by oral administration of a rapidly dissolving tablet comprising phentolamine mesylate, said tablet having a disintegration time of less than about twenty minutes and being capable of delivering to the blood circulation the amount of phentolamine mesylate effective to improve erectile ability within about one hour after administration.
Claim 27
Dependent Claim
38 words
The improvement of claim 21 wherein the amount of phentolamine mesylate effective to permit increased blood flow to the penis is achieved in the circulation from about ten minutes to one hour after oral administration of the formulation.
Claim 28
Dependent Claim
27 words
The improvement of claims 21 or 22 wherein the amount of phentolamine mesylate in said rapidly dissolving tablet is from about 5 mg to about 80 mg.
Claim 29
Dependent Claim
23 words
The improvement of claim 23 wherein said rapidly dissolving tablet has a disintegration time of from about one minute to about ten minutes.
Claim 30
Dependent Claim
18 words
The improvement of claim 23 wherein said rapidly dissolving tablet has a disintegration time less than one minute.
Claim 31
Dependent Claim
87 words
In a method for treating male impotence by administering a vasodilator to blood circulation in an amount effective to permit increased blood flow to the penis thereby improving erectile ability, the improvement comprising permitting increased blood flow to the penis by oral administration of a rapidly dissolving tablet comprising phentolamine hydrochloride, said tablet having a disintegration time of less than about twenty minutes and being capable of delivering to the blood circulation the amount of phentolamine hydrochloride effective to improve erectile ability within one hour after administration.
Claim 32
Dependent Claim
87 words
In a method for treating male impotence by administering a vasodilator to blood circulation in an amount effective to permit increased blood flow to the penis thereby improving erectile ability, the improvement comprising permitting increased blood flow to the penis by oral administration of a rapidly dissolving tablet comprising phentolamine hydrochloride, said tablet having a disintegration time of less than about twenty minutes and being capable of delivering to the blood circulation the amount of phentolamine hydrochloride effective to improve erectile ability within one hour after administration.
Claim 33
Dependent Claim
38 words
The improvement of claim 26 wherein the amount of phentolamine hydrochloride effective to permit increased blood flow to the penis is achieved in the circulation from about ten minutes to one hour after oral administration of the formulation.
Claim 34
Dependent Claim
27 words
The improvement of claims 26 or 27 wherein the amount of phentolamine hydrochloride in said rapidly dissolving tablet is from about 5 mg to about 80 mg.
Claim 35
Dependent Claim
23 words
The improvement of claim 28 wherein said rapidly dissolving tablet has a disintegration time of from about one minute to about ten minutes.
Claim 36
Dependent Claim
18 words
The improvement of claim 28 wherein said rapidly dissolving tablet has a disintegration time less than one minute.
Claim 37
Dependent Claim
27 words
The improvement of claims 21, 26, 22, or 27 wherein said rapidly dissolving tablet has a disintegration time of from about one minute to about ten minutes.
Claim 38
Dependent Claim
26 words
The improvement of claim 21, 26, 22, or 27 wherein said rapidly dissolving tablet has a disintegration time of about one minute to about ten minutes.
Claim 39
Dependent Claim
75 words
In a method for treating male impotence by administering a vasodilator agent to blood circulation in an amount effective to permit increased blood flow to the penis on demand, the improvement comprising the oral administration of a vasodilator formulation, the formulation comprising, from about 20 mg to about 80 mg of phentolamine mesylate whereby improvement in erectile ability occurs within from about 10 minutes to about 30 minutes after oral administration of the vasodilator formulation.
Claim 40
Dependent Claim
75 words
In a method for treating male impotence by administering a vasodilator agent to blood circulation in an amount effective to permit increased blood flow to the penis on demand, the improvement comprising the oral administration of a vasodilator formulation, the formulation comprising, from about 20 mg to about 80 mg of phentolamine mesylate whereby improvement in erectile ability occurs within from about 10 minutes to about 30 minutes after oral administration of the vasodilator formulation.
Claim 41
Dependent Claim
30 words
A composition comprising an orally administrable rapidly dissolving tablet comprising 40 mg phentolamine mesylate and a pharmaceutically acceptable carrier, said tablet having a disintegration time of less than one minute.
Claim 42
Dependent Claim
30 words
A composition comprising an orally administrable rapidly dissolving tablet comprising 40 mg phentolamine mesylate and a pharmaceutically acceptable carrier, said tablet having a disintegration time of less than one minute.
Claim 43
Dependent Claim
30 words
A composition comprising an orally administrable rapidly dissolving tablet comprising 80 mg phentolamine mesylate in a pharmaceutically acceptable carrier, said tablet having a disintegration time of less than one minute.
Claim 44
Dependent Claim
30 words
A composition comprising an orally administrable rapidly dissolving tablet comprising 80 mg phentolamine mesylate in a pharmaceutically acceptable carrier, said tablet having a disintegration time of less than one minute.
Claim 45
Dependent Claim
29 words
A composition comprising an orally administrable rapidly dissolving tablet comprising 40 mg phentolamine hydrochloride in a pharmaceutically acceptable carrier, said tablet having a disintegration of less than one minute.
Claim 46
Dependent Claim
29 words
A composition comprising an orally administrable rapidly dissolving tablet comprising 40 mg phentolamine hydrochloride in a pharmaceutically acceptable carrier, said tablet having a disintegration of less than one minute.
Claim 47
Dependent Claim
30 words
A composition comprising an orally administrable rapidly dissolving tablet comprising 80 mg phentolamine hydrochloride in a pharmaceutically acceptable carrier, said tablet having a disintegration time of less than one minute.
Claim 48
Dependent Claim
30 words
A composition comprising an orally administrable rapidly dissolving tablet comprising 80 mg phentolamine hydrochloride in a pharmaceutically acceptable carrier, said tablet having a disintegration time of less than one minute.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2001-03-23 | 2001-09-22 | 2002-03-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-03-23 | 2005-09-22 | 2006-03-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-03-23 | 2009-09-22 | 2010-03-24 | $7700.00 | Window Closed / Lapsed |