Patent US5562725A successfully refreshed from Google Patents.
US5079018A
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Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
Assignee: NEOPHORE TECHNOLOGIES Inc A CORP OF IL
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Filing: 1990-04-30
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Granted: 1992-01-07
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Expires: 2010-04-30
Abstract
Abstract A readily dissolvable carrier material having sufficient rigidity for administration of drugs, nutrients, vitamins, biologically-active materials, foodstuffs and combinations thereof capable of rapid dissolution by saliva, bodily fluids or other liquid comprising an interim skeletal structure of a watersoluble, hydratable gel or foam forming material, preferably a proteinaceous material, such as with maltodextran, in the hydrated state and dehydrated to leave spaces in place of hydration water. On dissolution by saliva, bodily fluids or other liquids, the composition becomes a liquid system. While the oral route is preferred, other routes may be used to administer the compositions of this method.
Inventors
- 👤 Bernard Ecanow
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 03:21
CPC Classifications
A; A23; A23C; A23C1/00; A23C1/06; A23C1/08; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0056; A61K9/20; A61K9/2095
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
107 words
A readily dissolvable carrier material having sufficient rigidity for administration of drugs, nutrients, vitamins, biologically-active materials, foodstuffs and combinations thereof capable of rapid dissolution by saliva comprising a porous skeletal structure of a water-soluble, hydratable gel or foam forming material that has been hydrated with water, rigidified in the hydrated state with a rigidifying agent in an amount, in proportion to the amount of gel or foam forming material, of about 0.1 to 5 times the weight of foam forming material, dry basis, and dehydrated with a liquid organic solvent at a temperature of about 0° C. or below to leave spaces in place of hydration liquid.
Claim 2
Dependent Claim
107 words
A readily dissolvable carrier material having sufficient rigidity for administration of drugs, nutrients, vitamins, biologically-active materials, foodstuffs and combinations thereof capable of rapid dissolution by saliva comprising a porous skeletal structure of a water-soluble, hydratable gel or foam forming material that has been hydrated with water, rigidified in the hydrated state with a rigidifying agent in an amount, in proportion to the amount of gel or foam forming material, of about 0.1 to 5 times the weight of foam forming material, dry basis, and dehydrated with a liquid organic solvent at a temperature of about 0° C. or below to leave spaces in place of hydration liquid.
Claim 3
Dependent Claim
32 words
The carrier material of claim 1 wherein the gel or foam material is selected from the group consisting of gelatin, gelatin A, gelatin B, fluid gelatin, modified fluid gelatin, albumin, and lecithin.
Claim 4
Dependent Claim
24 words
The carrier material of claim 2 wherein the rigidifying material is selected from the group consisting of a monosaccharide, a polysaccharide, and combinations thereof.
Claim 5
Dependent Claim
32 words
The carrier material of claim 3 wherein the rigidifying material is selected from the group consisting of dextrose, fructose, galactose, mannitol, xylitol, sorbitol, sucrose, lactose, maltose, dextrans, dextran derivatives and combinations thereof.
Claim 6
Dependent Claim
12 words
The carrier material of claim 4 wherein the rigidifying agent is maltodextran.
Claim 7
Dependent Claim
21 words
The carrier material of claim 5 wherein the maltodextran has a weight average molecular weight of about 40,000 to about 90,000.
Claim 8
Dependent Claim
35 words
The carrier material of claim 6 wherein the gel or foam material is a proteinaceous material selected from the group consisting of gelatin, gelatin A, gelatin B, fluid gelatin, modified fluid gelatin and mixtures thereof.
Claim 9
Dependent Claim
33 words
The carrier material of claim 1 wherein the hydrated gel or foam material has been dehydrated in a frozen state by contact with an organic solvent having a freezing point below 0° C.
Claim 10
Dependent Claim
39 words
The carrier material of claim 8 wherein the hydrated, frozen gel or foam material is dehydrated by immersing the frozen proteinaceous material in lower alcohol (C 1 to C 5 ) at a temperature of 0° C. or below.
Claim 11
Dependent Claim
161 words
A readily dissolvable, orally administrable solid, porous material containing a desired dosage of an active substance selected from the group consisting of a drug, nutrient, vitamin, biologically-active material, foodstuff, and combinations thereof capable of rapid dissolution when in contact with water or saliva and capable of delivering the active substance quickly to the bloodstream orally through the mouth tissue or gastrointestinal tract of an ingester of the material comprising a porous skeletal structure formed by freeze drying with a liquid organic solvent at a temperature of about 0° C. or below a water-soluble, gel or foam material that was hydrated with water, rigidified sufficiently in the hydrated state with a rigidifying agent in an amount, in proportion to the amount of gel or foam forming material, of about 0.1 to 5 times the weight of foam forming material, dry basis, for handleability of the dried material, containing an effective amount of the active material absorbed or adsorbed within the skeletal structure.
Claim 12
Dependent Claim
161 words
A readily dissolvable, orally administrable solid, porous material containing a desired dosage of an active substance selected from the group consisting of a drug, nutrient, vitamin, biologically-active material, foodstuff, and combinations thereof capable of rapid dissolution when in contact with water or saliva and capable of delivering the active substance quickly to the bloodstream orally through the mouth tissue or gastrointestinal tract of an ingester of the material comprising a porous skeletal structure formed by freeze drying with a liquid organic solvent at a temperature of about 0° C. or below a water-soluble, gel or foam material that was hydrated with water, rigidified sufficiently in the hydrated state with a rigidifying agent in an amount, in proportion to the amount of gel or foam forming material, of about 0.1 to 5 times the weight of foam forming material, dry basis, for handleability of the dried material, containing an effective amount of the active material absorbed or adsorbed within the skeletal structure.
Claim 13
Dependent Claim
24 words
The material of claim 10 further including a flavoring agent to mask an undesirable taste of the active material upon dissolution in the mouth.
Claim 14
Dependent Claim
34 words
The material of claim 10 wherein the gel or foam material is a proteinaceous material selected from the group consisting of gelatin, gelatin A, gelatin B, fluid gelatin, modified fluid gelatin, albumin, and lecithin.
Claim 15
Dependent Claim
23 words
The material of claim 12 wherein the rigidifying material is selected from the group consisting of a monosaccharide, a polysaccharide, and combinations thereof.
Claim 16
Dependent Claim
31 words
The material of claim 13 wherein the rigidifying material is selected from the group consisting of dextrose, fructose, galactose, mannitol, xylitol, sorbitol, sucrose, lactose, maltose, dextrans, dextran derivatives and combinations thereof.
Claim 17
Dependent Claim
11 words
The material of claim 14 wherein the rigidifying agent is maltodextran.
Claim 18
Dependent Claim
20 words
The material of claim 15 wherein the maltodextran has a weight average molecular weight of about 40,000 to about 90,000.
Claim 19
Dependent Claim
29 words
The material of claim 16 wherein the proteinaceous material is selected from the group consisting of gelatin, gelatin A, gelatin B, fluid gelatin, modified fluid gelatin and mixtures thereof.
Claim 20
Dependent Claim
36 words
The material of claim 10 wherein the hydrated gel or foam material has been dehydrated in a frozen state by contact with an organic solvent having a freezing point below 0° C. at near freezing temperature.
Claim 21
Dependent Claim
39 words
The material of claim 18 wherein the hydrated, frozen gel or foam material is dehydrated by immersing the frozen proteinaceous material in a lower alcohol (C 1 to C 5 ) at a temperature of 0° C. or below.
Claim 22
Independent Claim
165 words
A method of manufacturing a carrier material having sufficient rigidity for carrying and administration of an active material selected from the group consisting of drugs, nutrients, vitamins, biologically-active compounds, foodstuffs, and combinations thereof comprising the steps of: (a) freezing a solution comprising a water-soluble gel or foam material and a monosaccharide or polysaccharide rigidifying agent for said gel or foam material and water selected from the group consisting of coacervate phase water, equilibrium phase water and mixtures thereof; (b) contacting the frozen material of step (a) with the active material in an amount sufficient to cause the active material to be absorbed or adsorbed within the frozen material; (c) dehydrating the frozen material from step (b) by causing material transfer of water from the frozen material to an organic, liquid solvent while both the frozen material and the organic solvent are held at a temperature of about 0° C. or below; and (d) removing the organic solvent from the dehydrated material resulting form step (c).
Claim 23
Independent Claim
165 words
A method of manufacturing a carrier material having sufficient rigidity for carrying and administration of an active material selected from the group consisting of drugs, nutrients, vitamins, biologically-active compounds, foodstuffs, and combinations thereof comprising the steps of: (a) freezing a solution comprising a water-soluble gel or foam material and a monosaccharide or polysaccharide rigidifying agent for said gel or foam material and water selected from the group consisting of coacervate phase water, equilibrium phase water and mixtures thereof; (b) contacting the frozen material of step (a) with the active material in an amount sufficient to cause the active material to be absorbed or adsorbed within the frozen material; (c) dehydrating the frozen material from step (b) by causing material transfer of water from the frozen material to an organic, liquid solvent while both the frozen material and the organic solvent are held at a temperature of about 0° C. or below; and (d) removing the organic solvent from the dehydrated material resulting form step (c).
Claim 24
Dependent Claim
18 words
The method of claim 20 further including adding a flavoring material to the surface of the dehydrated material.
Claim 25
Dependent Claim
39 words
The method of claim 20 further including the step of adding a layer of the hydrated composition of step (a), in liquid form, onto the surface of the frozen composition resulting from step (a), and freezing the layers together.
Claim 26
Dependent Claim
28 words
The method of claim 22 including adding an active material to the frozen material resulting from step (a) prior to the addition of the layer of liquid composition.
Claim 27
Dependent Claim
37 words
The method of claim 23 further including adding an active material to the frozen material resulting from adding the layer of liquid over the frozen composition of step (a) either before or after freezing the added layer.
Claim 28
Dependent Claim
34 words
The method of claim 20 wherein the gel or foam material is a proteinaceous material selected from the group consisting of gelatin, gelatin A, gelatin B, fluid gelatin, modified fluid gelatin, albumin, and lecithin.
Claim 29
Dependent Claim
23 words
The method of claim 21 wherein the rigidifying material is selected from the group consisting of a monosaccharide, a polysaccharide, and combinations thereof.
Claim 30
Dependent Claim
31 words
The method of claim 26 wherein the rigidifying material is selected from the group consisting of dextrose, fructose, galactose, mannitol, xylitol, sorbitol, sucrose, lactose, maltose, dextrans, dextran derivatives and combinations thereof.
Claim 31
Dependent Claim
11 words
The method of claim 21 wherein the rigidifying agent is maltodextran.
Claim 32
Dependent Claim
20 words
The method of claim 24 wherein the maltodextran has a weight average molecular weight of about 40,000 to about 90,000.
Claim 33
Dependent Claim
32 words
The method of claim 20 wherein the hydrated gel or foam material has been dehydrated in a frozen state by contact with an organic solvent having a freezing point below 0° C.
Claim 34
Dependent Claim
41 words
The method of claim 30 wherein the hydrated, frozen gel or foam material is dehydrated by immersing the frozen gel or foam material in a lower alcohol (C 1 to C 5 ) at a temperature of 0° C. or below.
Claim 35
Independent Claim
147 words
A method of manufacturing a carrier material having sufficient rigidity for carrying and administration of an active material selected from the group consisting of drugs, nutrients, vitamins, biologically-active compounds, foodstuffs, and combinations thereof comprising: (a) freezing a solution comprising a water-soluble gel or foam material and a monosaccharide or polysaccharide rigidifying agent for said gel or foam material and water; (b) dehydrating the frozen material from step (a) by causing material transfer of water from the frozen material to an organic, liquid solvent while both the frozen material and the organic solvent are held at a temperature of about 0° C. or below; (c) removing the organic solvent from the dehydrated material resulting from step (b); and (d) adding to the carrier material, prior to freezing, an active material in an amount sufficient to cause the active material to be absorbed or adsorbed within the carrier material.
Claim 36
Independent Claim
147 words
A method of manufacturing a carrier material having sufficient rigidity for carrying and administration of an active material selected from the group consisting of drugs, nutrients, vitamins, biologically-active compounds, foodstuffs, and combinations thereof comprising: (a) freezing a solution comprising a water-soluble gel or foam material and a monosaccharide or polysaccharide rigidifying agent for said gel or foam material and water; (b) dehydrating the frozen material from step (a) by causing material transfer of water from the frozen material to an organic, liquid solvent while both the frozen material and the organic solvent are held at a temperature of about 0° C. or below; (c) removing the organic solvent from the dehydrated material resulting from step (b); and (d) adding to the carrier material, prior to freezing, an active material in an amount sufficient to cause the active material to be absorbed or adsorbed within the carrier material.
Claim 37
Dependent Claim
24 words
The method of claim 32 wherein the water is selected from the group consisting of coacervate phase water, equilibrium phase water and mixtures thereof.
References Cited (Backward Citations)
US473331A
Cited
US2166074A
Cited
JPS5017359A
Cited
FR2366835A1
Cited
US4343797A
Cited
EP0084705A2
Cited
US4539204A
Cited
US4596788A
Cited
US4616047A
Cited
US4752466A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-01-06 | 1995-07-08 | 1996-01-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-01-06 | 1999-07-08 | 2000-01-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-01-06 | 2003-07-08 | 2004-01-07 | $7700.00 | Window Closed / Lapsed |