Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
214 words
A transdermal absorption preparation which comprises a drug-storing layer containing a drug and having a drug-releasing face coated with a drug-releasing controlling membrane, wherein said drug-storing layer comprises as a base a heat-sensitive segmented polyurethane represented by the general formula: R--A--(U)--F--(U)--B--R' wherein A represents a polymer of ethylene oxide, propylene oxide, tetramethylene oxide or 1,2-butylene oxide, or a random or block copolymer thereof, B represents a random or block copolymer of ethylene oxide, propylene oxide, tetramethylene oxide and/or 1,2-butylene oxide, R and R', which may be the same or different, each represents a terminal H, CH 3 , C 2 H 5 , C 3 H 7 or C 4 H 9 , F represents a constituting structure which is a residual moiety of a diisocyanate compound excluding two isocyanate groups, and (U) represents a urethane bond, and at least one of A and B is hydrophilic and at the same time at least one of A and B has a characteristic that it melts near the temperature of human skin (30° to 40° C.); wherein the viscosity of the seqmented polyurethane after melting is about 2,000 centipoise or less; and wherein said drug-releasing controlling membrane is a phase-separated membrane comprising a mixture of a crosslinked gelatin phase and an uncrosslinked segmented polyurethane phase.
Claim 2
Dependent Claim
214 words
A transdermal absorption preparation which comprises a drug-storing layer containing a drug and having a drug-releasing face coated with a drug-releasing controlling membrane, wherein said drug-storing layer comprises as a base a heat-sensitive segmented polyurethane represented by the general formula: R--A--(U)--F--(U)--B--R' wherein A represents a polymer of ethylene oxide, propylene oxide, tetramethylene oxide or 1,2-butylene oxide, or a random or block copolymer thereof, B represents a random or block copolymer of ethylene oxide, propylene oxide, tetramethylene oxide and/or 1,2-butylene oxide, R and R', which may be the same or different, each represents a terminal H, CH 3 , C 2 H 5 , C 3 H 7 or C 4 H 9 , F represents a constituting structure which is a residual moiety of a diisocyanate compound excluding two isocyanate groups, and (U) represents a urethane bond, and at least one of A and B is hydrophilic and at the same time at least one of A and B has a characteristic that it melts near the temperature of human skin (30° to 40° C.); wherein the viscosity of the seqmented polyurethane after melting is about 2,000 centipoise or less; and wherein said drug-releasing controlling membrane is a phase-separated membrane comprising a mixture of a crosslinked gelatin phase and an uncrosslinked segmented polyurethane phase.
Claim 3
Dependent Claim
20 words
A transdermal absorption preparation as claimed in claim 1, wherein A in the general formula is an ethylene oxide polymer.
Claim 4
Dependent Claim
27 words
A transdermal absorption preparation as claimed in claim 1, wherein B in the general formula is a random or block copolymer of ethylene oxide and propylene oxide.
Claim 5
Dependent Claim
30 words
A transdermal absorption preparation as claimed in claim 1, wherein A is an ethylene oxide polymer and B is a random or block copolymer of ethylene oxide and propylene oxide.
Claim 6
Dependent Claim
30 words
A transdermal absorption preparation as claimed in any of claims 1, 2, or 4, wherein a number average molecular weight of said ethylene oxide polymer is from 800 to 1,200.
Claim 7
Dependent Claim
37 words
A transdermal absorption preparation as claimed in claim 1, wherein a total molecular weight of said segmented polyurethane serving as a base of a drug-storing layer is a number average molecular weight of from 1,000 to 6,000.
Claim 8
Dependent Claim
20 words
A transdermal absorption preparation as claimed in claim 1, wherein glycerin and/or polyglycerin is contained in the drug-releasing controlling membrane.
Claim 9
Dependent Claim
49 words
A transdermal absorption preparation as claimed in claim 1, wherein said diisocyanate is a diisocyanate selected from the group consisting of p-phenylene diisocyanate, 2,4-toluylene diisocyanate, 4,4-diphenylmethane diisocyanate, naphthalene 1,5-diisocyanate, hexamethylene diisocyanate, tetramethylene diisocyanate, lysine diisocyanate, xylylene diisocyanate and hydrogenated 2,4-toluylene diisocyanate, hydrogenated 4,4-diphenylmethane diisocyanate, dicyclohexyldimethylmethane p,p'-diisocyanate, and isophorone diisocyanate.