US5716625A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Formulations and methods for reducing skin irritation
Assignee: Galleon Labs LLC
•
Filing: 1994-12-21
•
Granted: 1998-02-10
•
Expires: 2014-12-21
Abstract
Abstract Topical formulations comprising an anti-irritant amount of aqueous-soluble strontium (Sr2+) cation, and methods for using the same to inhibit skin irritation, are disclosed.
Inventors
- 👤 Gary Scott Hahn
- 👤 David Orel Thueson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 02:01
CPC Classifications
A; A61; A61Q; A61Q19/00; A61Q19/10; A61K; A61K31/00; A61K31/28; A61K33/00; A61K33/24; A61K8/00; A61K8/18; A61K8/19; A61K8/20; A61K8/30; A61K8/33; A61K8/36; A61K8/365; A61P; A61P17/00; A61P17/04; A61K2800/00; A61K2800/74; A61K2800/75; A61Q1/00; A61Q1/02; A61Q1/04; A61Q1/06; A61Q15/00; A61Q17/00; A61Q5/00; A61Q5/04; A61Q5/12; A61Q9/00; A61Q9/02
Claims Analysis
Total Claims: 56
Claim 1
Independent Claim
108 words
A composition for topical application to an animal subject comprising a topical vehicle; an irritant ingredient selected from the group consisting of carboxylic acids, keto acids, α-hydroxy acids, β-hydroxy acids, retinoids, peroxides, organic alcohols and mixtures thereof said irritant ingredient being contained in an amount capable of inducing skin irritation in said subject; and an anti-irritant metal cation, said consisting essentially of aqueous-soluble divalent strontium cation, said anti-irritant metal cation being contained in a concentration of at least about 5.0 mM and capable of inhibiting mean cumulative skin irritation attributable to said irritant ingredient in the human population susceptible to said skin irritation by at least about 20%.
Claim 2
Dependent Claim
108 words
A composition for topical application to an animal subject comprising a topical vehicle; an irritant ingredient selected from the group consisting of carboxylic acids, keto acids, α-hydroxy acids, β-hydroxy acids, retinoids, peroxides, organic alcohols and mixtures thereof said irritant ingredient being contained in an amount capable of inducing skin irritation in said subject; and an anti-irritant metal cation, said consisting essentially of aqueous-soluble divalent strontium cation, said anti-irritant metal cation being contained in a concentration of at least about 5.0 mM and capable of inhibiting mean cumulative skin irritation attributable to said irritant ingredient in the human population susceptible to said skin irritation by at least about 20%.
Claim 3
Dependent Claim
20 words
The composition of claim 1 comprising strontium cation in a concentration of from about 50 mM to about 3000 mM.
Claim 4
Dependent Claim
20 words
The composition of claim 1 comprising strontium cation in a concentration of from about 50 mM to about 2000 mM.
Claim 5
Dependent Claim
20 words
The composition of claim 1 comprising strontium cation in a concentration of from about 100 mM to about 1000 mM.
Claim 6
Dependent Claim
20 words
The composition of claim 1 comprising strontium cation in a concentration of from about 250 mM to about 500 mM.
Claim 7
Dependent Claim
68 words
The composition of claim 1 wherein said inhibition of skin irritation represents an average reduction in one or more of sting, burn and itch in the human population susceptible to said skin irritation upon topical application of said composition, as compared to the level of irritation induced in said population upon topical application of a control formulation containing said irritant ingredient in a vehicle without said strontium cation.
Claim 8
Dependent Claim
41 words
The composition of claim 1 comprising an amount of strontium cation capable of inhibiting by at least about 40% the cumulative skin irritation attributable to said irritant ingredient in at least 10% of the human population susceptible to said skin irritation.
Claim 9
Dependent Claim
77 words
The composition of claim 7 wherein said inhibition of skin irritation represents an average reduction in one or more of sting, burn and itch in at least 10% of the human population susceptible to said skin irritation upon topical application of said composition, as compared to the level of irritation induced in said at least 10% of the population upon topical application of a control formulation containing said irritant ingredient in a vehicle without said strontium cation.
Claim 10
Dependent Claim
12 words
The composition of claim 1 wherein said composition is a cosmetic product.
Claim 11
Dependent Claim
19 words
The composition of claim 9 wherein said composition comprises a skin exfolient, skin peel or skin cell renewal agent.
Claim 12
Dependent Claim
16 words
The composition of claim 1 wherein said irritant ingredient comprises lactic acid or a salt thereof.
Claim 13
Dependent Claim
16 words
The composition of claim 1 wherein said irritant ingredient comprises glycolic acid or a salt thereof.
Claim 14
Dependent Claim
16 words
The composition of claim 1 wherein said irritant ingredient comprises salicylic acid or a salt thereof.
Claim 15
Dependent Claim
21 words
The composition of claim 1 wherein said irritant ingredient comprises a combination of lactic acid and salicylic acid, or salts thereof.
Claim 16
Dependent Claim
17 words
The composition of claim 1 wherein stud irritant ingredient comprises capryloyl salicylic acid or a salt thereof.
Claim 17
Dependent Claim
16 words
The composition of claim 1 wherein said irritant ingredient comprises citric acid or a salt thereof.
Claim 18
Dependent Claim
18 words
The composition of claim 1 wherein said irritant ingredient is a retinoid selected from tretinoin, retinol, and retinal.
Claim 19
Dependent Claim
12 words
The composition of claim 1 wherein said irritant ingredient comprises benzoyl peroxide.
Claim 20
Dependent Claim
16 words
The composition of claim 1 wherein said irritant ingredient comprises acetic acid or a salt thereof.
Claim 21
Dependent Claim
48 words
The composition of claim 1 wherein said irritant ingredient comprises an ingredient selected from the group consisting of 1-pyrrolidone-5-carboxylic acid, capryloyl salicylic acid, α-hydroxy decanoic acid, α-hydroxy octanoic acid, gluconolactone, methoxypropyl gluconamide, oxalic acid, malic acid, tartaric acid, mandelic acid, benzylic acid, gluconic acid, pyruvic acid and phenol.
Claim 22
Dependent Claim
16 words
The composition of claim 1 wherein said irritant ingredient comprises trichloroacetic acid of a salt thereof.
Claim 23
Dependent Claim
19 words
The composition of claim 1 wherein the pH of the composition is in the range of 1 to 6.
Claim 24
Dependent Claim
19 words
The composition of claim 1 wherein the pH of the composition is in the range of 3 to 5.
Claim 25
Dependent Claim
19 words
The composition of claim 1 having a concentration of said irritant ingredient of from about 0.1% to about 50%.
Claim 26
Dependent Claim
19 words
The composition of claim 1 having a concentration of said irritant ingredient of from about 0.5% to about 20%.
Claim 27
Dependent Claim
14 words
The composition of claim 1 wherein said composition is an antiperspirant or deodorant product.
Claim 28
Dependent Claim
16 words
The composition of claim 1 wherein said composition is a sunscreen, tanning or sunburn treatment product.
Claim 29
Dependent Claim
13 words
The composition of claim 1 wherein said composition is an insect repellant product.
Claim 30
Dependent Claim
29 words
The composition of claim 9 wherein said composition is a shaving or hair removal product selected from the group consisting of depilatory, bracer, cream, foam, gel and aftershave products.
Claim 31
Dependent Claim
16 words
The composition of claim 9 wherein said composition is a hair care or hair treatment product.
Claim 32
Dependent Claim
26 words
The composition of claim 30 wherein said composition is selected from the group consisting of shampoo, conditioner, colorant, dye, bleach, permanent wave and hair straightener products.
Claim 33
Dependent Claim
22 words
The composition of claim 9 wherein said composition is selected from the group consisting of cleansers, astringents, toners, rinses, serums and masks.
Claim 34
Dependent Claim
13 words
The composition of claim 9 wherein said composition is a facial cosmetic product.
Claim 35
Dependent Claim
19 words
The composition of claim 9 wherein said composition is selected from the group consisting of creams, lotions and moisturizers.
Claim 36
Dependent Claim
18 words
The composition of claim 1 wherein said composition is selected from the group consisting of soaps and detergents.
Claim 37
Dependent Claim
13 words
The composition of claim 1 wherein said composition is a topical drug product.
Claim 38
Dependent Claim
11 words
The composition of claim 36 wherein said irritant ingredient is capsaicin.
Claim 39
Dependent Claim
22 words
The composition of claim 36 wherein said composition is selected from the group consisting of antibiotic, analgesic, contraceptive, anti-acne and anti-dandruff products.
Claim 40
Dependent Claim
12 words
The composition of claim 38 wherein said irritant ingredient is benzoyl peroxide.
Claim 41
Dependent Claim
23 words
The composition of claim 1 wherein said composition is formulated as a rectal or vaginal suppository, foam, cream, gel, enema, douche or ointment.
Claim 42
Dependent Claim
18 words
The composition of claim 1 wherein said composition is formulated for administration to the mouth, throat or lip.
Claim 43
Dependent Claim
12 words
The composition of claim 41 formulated as a lozenge, mouthwash or gargle.
Claim 44
Dependent Claim
15 words
The composition of claim 1 formulated as a liquid, gel, cream, emulsion, suspension or stick.
Claim 45
Dependent Claim
10 words
The composition of claim 1 formulated with a physical applicator.
Claim 46
Dependent Claim
23 words
The composition of claim 44 wherein said physical applicator is selected from the group consisting of cloths, tissues, swabs, bandages and wet wipes.
Claim 47
Dependent Claim
20 words
The composition of claim 1, further comprising, as counteranions to said strontium cation, one or more topically acceptable anion species.
Claim 48
Dependent Claim
62 words
The composition of claim 1 further comprising, as counteranions to said strontium cation, one or more anion species selected from the group consisting of nitrate, halogen, carbonate, bicarbonate, hydroxide, oxide, peroxide, nitrite, sulfide, bisulfate, persulfate, glycerophosphate, hypophosphate, borate and titanate inorganic anions, and carboxylic acid, alkoxylate, amino acid, peptide, saturated and unsaturated organic acid, and saturated and unsaturated fatty acid organic anions.
Claim 49
Dependent Claim
61 words
The composition of claim 47 wherein said one or more of said counteranions is an organic anion selected from the group consisting of citrate, oxalate, acetate, gluconate, lactate, tartrate, maleate, benzoate, propionate, salicylate, ascorbate, formate, succinate, folinate, aspartate, phthalate, oleate, palmitate, stearate, lauryl sulfate, lanolate, myristate, behenate, caseinate, cyclamate, pantothenate, polyaminopolycarboxylates, saccharin, thioglycolate, laurate, methylparaben, propylparaben, ricinoleate and sorbate organic anions.
Claim 50
Dependent Claim
11 words
The composition of claim 46 wherein said anion species includes nitrate.
Claim 51
Dependent Claim
18 words
The composition of claim 46 wherein said anion species includes a halogen selected from chloride and fluoride anions.
Claim 52
Dependent Claim
13 words
The composition of claim 1 further comprising at least one second anti-irritant agent.
Claim 53
Dependent Claim
48 words
The composition of claim 51 wherein the total amount of said strontium cation and said second agent is capable of inhibiting by at least about 40% the cumulative skin irritation attributable to said irritant ingredient in at least 10% of the human population susceptible to said skin irritation.
Claim 54
Dependent Claim
61 words
The composition of claim 51 wherein said second agent is selected from the group consisting of potassium channel mediating, regulating or blocking agents, calcium channel blocking or regulatory agents, sodium channel blocking agents, steroids, non-steroidal anti-inflammatory agents, aloe vera, chamomile, α-bisabolol, cola nitida extract, green tea extract, tea tree oil, licorice extract, allantoin, urea, caffeine and other xanthines, and glycyrrhizic acid.
Claim 55
Independent Claim
92 words
A method of inhibiting skin irritation associated with an irritant ingredient contained in an applied topical formulation, said irritant ingredient being selected from the group consisting of carboxylic acids, keto acids, α-hydroxy acids, β-hydroxy acids, retinoids, peroxide, organic alcohols, and mixtures thereof comprising topically administering to an animal subject composition comprising a topical vehicle; said irritant ingredient contained in an amount capable of inducing skin irritation in said subject; and an anti-irritant amount of aqueous-soluble divalent strontium cation, said strontium cation being contained in a concentration of at least about 50 mM.
Claim 56
Independent Claim
92 words
A method of inhibiting skin irritation associated with an irritant ingredient contained in an applied topical formulation, said irritant ingredient being selected from the group consisting of carboxylic acids, keto acids, α-hydroxy acids, β-hydroxy acids, retinoids, peroxide, organic alcohols, and mixtures thereof comprising topically administering to an animal subject composition comprising a topical vehicle; said irritant ingredient contained in an amount capable of inducing skin irritation in said subject; and an anti-irritant amount of aqueous-soluble divalent strontium cation, said strontium cation being contained in a concentration of at least about 50 mM.
References Cited (Backward Citations)
US3716054A
Cited
US4105782A
Cited
US4105783A
Cited
US4191750A
Cited
US4285973A
Cited
US4477439A
Cited
US4388301A
Cited
US4943432A
Cited
US4971800A
Cited
US5262153A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-02-09 | 2001-08-11 | 2002-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-02-09 | 2005-08-11 | 2006-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-02-09 | 2009-08-11 | 2010-02-10 | $7700.00 | Window Closed / Lapsed |