US4943432A
Expired / Lapsed
US
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Salt mixture for the treatment of psoriasis
Assignee: PSORI-MED AG
•
Filing: 1988-08-24
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Granted: 1990-07-24
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Expires: 2008-08-24
Abstract
Abstract A composition for the treatment of psoriasis and other skin diseases comprising a salt mixture of defined purity, which is applied to the diseased skin in solution or in gelled form. The composition may be characterized as composed primarily of a mixture of a magnesium halide, such as magnesium chloride, with mixed alkali and alkaline earth metal salts such as sodium and potassium chloride and/or bromide and calcium chloride or bromide. Other cations present in the mixture include strontium, aluminum, iron, lithium and zinc, and the anions include sulphate, hydrogen carbonate, borate, fluoride, silicate, iodide and carbonate.
Inventors
- 👤 Hans F. Biener
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 17:53
CPC Classifications
A; A61; A61Q; A61Q19/00; A61K; A61K33/00; A61K8/00; A61K8/18; A61K8/19; A61K8/20; A61K8/23
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
141 words
A composition for the treatment of psoriasis by application to the skin, said composition prepared by forming a mixture of salt components such that the salt components are present in the mixture in the following proportions, expressed as grams/kilogram of salt mixture in the ionic state: ______________________________________
Cations (g./kg salt mixture)
Anions (g./kg salt mixture)
______________________________________
magnesium
55 to 108 chloride 340 to 550
sodium 51 to 126 bromide 1.5 to 15
calcium 19 to 36 sulfate 1.1 to 9
potassium
10 to 21 borate 0.4 to 3
strontium
0.2 to 2.0 silicate 0.1 to 2.9
iron 0.18 to 1.9 fluoride 0.1 to 2.2
aluminum 0.006 to 1.2 iodide 0.1 to 2.0
zinc 0.02 to 0.8 carbonate 0.01 to 1.0
lithium 0.004 to 0.7 hydrogen 0.01 to 1.0
carbonate
______________________________________ said composition further characterized as being essentially free of organic impurities.
Claim 2
Dependent Claim
141 words
A composition for the treatment of psoriasis by application to the skin, said composition prepared by forming a mixture of salt components such that the salt components are present in the mixture in the following proportions, expressed as grams/kilogram of salt mixture in the ionic state: ______________________________________
Cations (g./kg salt mixture)
Anions (g./kg salt mixture)
______________________________________
magnesium
55 to 108 chloride 340 to 550
sodium 51 to 126 bromide 1.5 to 15
calcium 19 to 36 sulfate 1.1 to 9
potassium
10 to 21 borate 0.4 to 3
strontium
0.2 to 2.0 silicate 0.1 to 2.9
iron 0.18 to 1.9 fluoride 0.1 to 2.2
aluminum 0.006 to 1.2 iodide 0.1 to 2.0
zinc 0.02 to 0.8 carbonate 0.01 to 1.0
lithium 0.004 to 0.7 hydrogen 0.01 to 1.0
carbonate
______________________________________ said composition further characterized as being essentially free of organic impurities.
Claim 3
Dependent Claim
51 words
A solution for the treatment of psoriasis by application to the skin, said solution prepared by dissolving the composition of claim 1 in water, said solution further characterized as being essentially free of organic impurities and having a solids concentration within the range of about 0.1 to about 34% by weight.
Claim 4
Dependent Claim
21 words
The solution of claim 2 wherein the solids concentration is within the range of about 0.5 to about 26% by weight.
Claim 5
Dependent Claim
24 words
The solution of claim 2 wherein the solids concentration of the solution is within the range of about 0.1 to about 26% by weight.
Claim 6
Dependent Claim
21 words
The solution of claim 4 wherein the solids concentration is within the range of about 7 to about 26% by weight.
Claim 7
Dependent Claim
22 words
A gel comprising the solution of claim 2 mixed with a sufficient amount of a natural or synthetic gum or colloid additive.
Claim 8
Dependent Claim
25 words
The gel of claim 6 wherein said additive is a cellulose ether or ester present at a level of about 1 to 2% by weight.
Claim 9
Dependent Claim
138 words
A composition for the treatment of psoriasis by application to the skin, said composition prepared by forming a mixture comprising the following components in the following approximate proportions: ______________________________________
659 parts by wt.
Magnesium chlorid (MgCl.sub.2.6H.sub.2 O)
213 " Sodium chloride (NaCl)
198 " Calcium chloride (CaCl.sub.2.2H.sub.2 O)
27 " Potassium chloride (KCl)
12 " Sodium bromide (NaBr)
5.4 " Magnesium sulphate (MgSO.sub.4)
1.5 " Strontium chloride (SrCl.sub.2.6H.sub.2 O)
0.4 " Sodium hydrogencarbonate (NaHCO.sub.3)
0.244 " Aluminum sulfate (Al.sub.2 SO.sub.4.18H.sub.2 O)
0.227 " Sodium tetraborate (Na.sub.2 B.sub.4 O.sub.7.10H.sub.2
O)
0.190 " Lithium chloride (LiCl)
0.105 " Iron sulfate (FeSO.sub.4)
0.094 " Sodium fluoride (NaF)
0.087 " Sodium metasilicate (Na.sub.2 SiO.sub.3)
0.042 " Potassium iodide (KI)
0.040 " Sodium carbonate (Na.sub.2 CO.sub.3)
0.018 " Zinc chloride (ZnCl.sub.2),
______________________________________ said composition further characterized as being essentially free of organic impurities.
Claim 10
Dependent Claim
138 words
A composition for the treatment of psoriasis by application to the skin, said composition prepared by forming a mixture comprising the following components in the following approximate proportions: ______________________________________
659 parts by wt.
Magnesium chlorid (MgCl.sub.2.6H.sub.2 O)
213 " Sodium chloride (NaCl)
198 " Calcium chloride (CaCl.sub.2.2H.sub.2 O)
27 " Potassium chloride (KCl)
12 " Sodium bromide (NaBr)
5.4 " Magnesium sulphate (MgSO.sub.4)
1.5 " Strontium chloride (SrCl.sub.2.6H.sub.2 O)
0.4 " Sodium hydrogencarbonate (NaHCO.sub.3)
0.244 " Aluminum sulfate (Al.sub.2 SO.sub.4.18H.sub.2 O)
0.227 " Sodium tetraborate (Na.sub.2 B.sub.4 O.sub.7.10H.sub.2
O)
0.190 " Lithium chloride (LiCl)
0.105 " Iron sulfate (FeSO.sub.4)
0.094 " Sodium fluoride (NaF)
0.087 " Sodium metasilicate (Na.sub.2 SiO.sub.3)
0.042 " Potassium iodide (KI)
0.040 " Sodium carbonate (Na.sub.2 CO.sub.3)
0.018 " Zinc chloride (ZnCl.sub.2),
______________________________________ said composition further characterized as being essentially free of organic impurities.
Claim 11
Dependent Claim
51 words
A solution for the treatment of psoriasis by application to the skin, said solution prepared by dissolving the composition of claim 8 in water, said solution further characterized as being essentially free of organic impurities and having a solids concentration within the range of about 0.1 to about 34% by weight.
Claim 12
Dependent Claim
17 words
A method for treating psoriasis comprising contacting the affected skin areas with the solution of claim 9.
Claim 13
Dependent Claim
21 words
A method for treating psoriasis comprising contacting the affected skin areas with an aqueous solution of the composition of claim 1.
Claim 14
Dependent Claim
25 words
The method of claim 11 wherein the solid content of said solution is within the range of from about 0.5 to about 26% by weight.
Claim 15
Dependent Claim
26 words
The method of claim 12 wherein the affected skin areas are simultaneously exposed to ultraviolet radiation during at least a portion of said period of contact.
Claim 16
Dependent Claim
17 words
A method for treating psoriasis comprising contacting the affected skin areas with the solution of claim 4.
Claim 17
Dependent Claim
26 words
The method of claim 14 wherein the affected skin areas are simultaneously exposed to ultraviolet radiation during at least a portion of said period of contact.
Claim 18
Dependent Claim
17 words
A method for treating psoriasis comprising contacting the affected skin areas with the gel of claim 6.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1993-07-23 | 1994-01-22 | 1994-07-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-07-23 | 1998-01-22 | 1998-07-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-07-23 | 2002-01-22 | 2002-07-24 | $7700.00 | Window Closed / Lapsed |