US5713847A
Expired / Lapsed
US
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Human drug delivery device for tinnitus
Assignee: University of Iowa Research Foundation
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Filing: 1996-02-06
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Granted: 1998-02-03
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Expires: 2016-02-06
Abstract
Abstract A neural prosthetic drug delivery apparatus for reducing or eliminating the effects of tinnitus. The apparatus includes a catheter which is inserted into the patient's auditory cortex or thalamus. The catheter microinfuses drugs which suppress or eliminate abnormal neural activity into geometrically separate locations of the patient's brain, thereby reducing or eliminating the effects of tinnitus. In one embodiment the apparatus includes a stimulation device for outputting processed electrical signals and an electrode having a plurality of electrical contacts which is arranged in a target zone of the patient's brain. Each of the plurality of electrical contacts independently outputs electrical discharges in accordance with the electrical signals.
Inventors
- 👤 Matthew A. Howard, III
- 👤 Timothy M. McCulloch
- 👤 Carol A. Bauer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 18:17
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/142; A61M5/14244; A61M5/14276; A61B; A61B18/00; A61B18/04; A61B18/12; A61B18/14; A61B18/148; A61F; A61F11/00; A61F5/00; A61F5/0003; A61F5/0013; A61F5/0026; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/05; A61N1/0526; A61N1/0529; A61N1/0531; A61N1/0539; A61N1/0541; A61N1/18; A61N1/32; A61N1/326; A61N1/36; A61N1/3605; A61N1/3606; A61N1/36082; A61N1/361; A61B2018/00315; A61B2018/00434; A61B2018/00571; A61B2018/00577; A61B2018/00636; A61B2018/00773; A61B2018/00839; A61B90/00; A61B90/10; A61F11/20; A61M2210/00; A61M2210/06; A61M2210/0693; A61M27/00; A61M27/002; A61M27/006; A61M5/1428; A61M5/168; A61M5/172; A61M5/1723
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
93 words
A neural therapeutic apparatus for treatment of a patient with tinnitus, comprising: a drug reservoir-pump for containing and pumping a drug, wherein said drug is capable of reducing abnormal neural activity associated with tinnitus; and a drug delivering catheter for arrangement in the patient's auditory, cortex or thalamus, said drug delivering catheter operatively connected to said drug reservoir-pump, and said drug delivering catheter having a plurality of ports, each of said plurality of ports capable of outputting said drug to predetermined geometric locations within said one of the patient's auditory, cortex and thalamus.
Claim 2
Dependent Claim
93 words
A neural therapeutic apparatus for treatment of a patient with tinnitus, comprising: a drug reservoir-pump for containing and pumping a drug, wherein said drug is capable of reducing abnormal neural activity associated with tinnitus; and a drug delivering catheter for arrangement in the patient's auditory, cortex or thalamus, said drug delivering catheter operatively connected to said drug reservoir-pump, and said drug delivering catheter having a plurality of ports, each of said plurality of ports capable of outputting said drug to predetermined geometric locations within said one of the patient's auditory, cortex and thalamus.
Claim 3
Dependent Claim
102 words
The neural therapeutic apparatus as claimed in claim 1, further comprising: a stimulation device for outputting electrical signals; and a stimulating and recording electrode arranged in said drug delivering catheter, said electrode having a plurality of electrical contacts electrically coupled to said stimulation device, and each of said plurality of electrical contacts outputting one or more electrical discharges in accordance with said electrical signals, wherein each of said electrical contacts is capable of receiving electrical discharges in said one of the patient's auditory, cortex and thalamus, and wherein said electrical discharge output blocks abnormal neural activity and alleviates the symptoms of tinnitus.
Claim 4
Dependent Claim
22 words
The neural therapeutic apparatus as claimed in claim 1, wherein said drug capable of reducing abnormal neural activity comprises a neurotransmitter inhibitor.
Claim 5
Dependent Claim
21 words
The neural therapeutic apparatus as claimed in claim 1, wherein said drug capable of reducing abnormal neural activity comprises an anticonvulsant.
Claim 6
Dependent Claim
23 words
The neural therapeutic apparatus as claimed in claim 1, wherein said drug capable of reducing abnormal neural activity comprises dilantin or γ-aminobutyric acid.
Claim 7
Dependent Claim
15 words
The neural therapeutic apparatus of claim 1, wherein said drug delivering catheter comprises silastic material.
Claim 8
Dependent Claim
23 words
The neural therapeutic apparatus of claim 1, wherein said drug delivering catheter has a cross-sectional shape which is substantially circular or substantially elliptical.
Claim 9
Dependent Claim
22 words
The neural therapeutic apparatus of claim 1, wherein said plurality of ports are arranged at discrete locations on said drug delivering catheter.
Claim 10
Dependent Claim
46 words
The neural therapeutic apparatus of claim 8, wherein each of said plurality of ports are substantially circular and are from about 10 micrometers to about 2 millimeters in diameter, and wherein said plurality of ports are spaced from about 6 micrometers to about 2 millimeters apart.
Claim 11
Dependent Claim
34 words
The neural therapeutic apparatus of claim 9, wherein the centers of each of said plurality of ports are separated by a distance in the range of from about 20 micrometers to about 2 millimeters.
Claim 12
Dependent Claim
130 words
A neural therapeutic apparatus for implantation in a target zone of a patient's brain, comprising: a reservoir-pump for containing a drug, said drug capable of reducing abnormal neural activity, associated with tinnitus; a catheter for delivering said drug to the target zone of the patient's brain, said catheter operably connected to said reservoir-pump, and comprising one or more stimulating and recording electrodes; a stimulation device for outputting electrical signals to said one or more electrodes, said electrodes outputting electrical discharges in accordance with said electrical signals, wherein said outputted electrical discharges block abnormal neural activity; and a recording device operably connected to said one or more electrodes, said recording device capable of recording electrophysiologic data received by said one or more electrodes, from said target zone of the patient's brain.
Claim 13
Dependent Claim
130 words
A neural therapeutic apparatus for implantation in a target zone of a patient's brain, comprising: a reservoir-pump for containing a drug, said drug capable of reducing abnormal neural activity, associated with tinnitus; a catheter for delivering said drug to the target zone of the patient's brain, said catheter operably connected to said reservoir-pump, and comprising one or more stimulating and recording electrodes; a stimulation device for outputting electrical signals to said one or more electrodes, said electrodes outputting electrical discharges in accordance with said electrical signals, wherein said outputted electrical discharges block abnormal neural activity; and a recording device operably connected to said one or more electrodes, said recording device capable of recording electrophysiologic data received by said one or more electrodes, from said target zone of the patient's brain.
Claim 14
Dependent Claim
40 words
The neural therapeutic apparatus of claim 11, wherein said catheter includes a plurality of ports, each of said plurality of ports capable of outputting said drug to a geometrically separate, predetermined location within said target zone of the patient's brain.
Claim 15
Dependent Claim
78 words
The neural therapeutic apparatus of claim 11, wherein said electrode has a plurality of electrical contacts, each of said plurality of electrical contacts electrically coupled to said stimulation device, with each of said plurality of electrical contacts capable of outputting electrical discharges to said target zone of the patient's brain, wherein each of said plurality, of electrical contacts is further capable of receiving electrical discharges for recording as electrophysiologic data from said target zone of the patient's brain.
Claim 16
Dependent Claim
22 words
The neural therapeutic apparatus of claim 11, wherein said reservoir-pump includes a recharging valve, and wherein said recharging valve is externally accessible.
Claim 17
Dependent Claim
29 words
The neural therapeutic apparatus of claim 11, wherein said reservoir-pump is adapted for attachment to the patient's head, and wherein said reservoir-pump is adjustable by a radio control means.
Claim 18
Dependent Claim
25 words
The neural therapeutic apparatus of claim 11, wherein said drug is selected from the group consisting of an anticonvulsant, a neurotransmitter and a local anesthetic.
Claim 19
Dependent Claim
68 words
A neural therapeutic drug delivery apparatus for implantation in a target zone of a patient's brain, comprising: means for delivering a drug to said target zone of the patient's brain, said drug capable of reducing abnormal neural activity associated with tinnitus; means for outputting electrical discharges to said target zone of the patient's brain; and means for receiving electrical discharges from said target zone of the patient's brain.
Claim 20
Dependent Claim
68 words
A neural therapeutic drug delivery apparatus for implantation in a target zone of a patient's brain, comprising: means for delivering a drug to said target zone of the patient's brain, said drug capable of reducing abnormal neural activity associated with tinnitus; means for outputting electrical discharges to said target zone of the patient's brain; and means for receiving electrical discharges from said target zone of the patient's brain.
Claim 21
Dependent Claim
66 words
The neural therapeutic drug delivery, apparatus of claim 17, wherein said means for outputting electrical discharges and said means for receiving electrical discharges comprise one or more stimulating and recording electrodes, and said means for delivering said drug comprises a catheter comprising one or more ports capable of outputting said drug to one or more predetermined, separate locations within said target zone of the patient's brain.
Claim 22
Dependent Claim
42 words
The neural therapeutic drug delivery apparatus of claim 18, wherein said means for delivering said drug further comprises a radio-controlled pump connected to said catheter, and wherein said target zone is an auxiliary cortex or a medial geniculate nucleus of a thalamus.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-02-02 | 2001-08-04 | 2002-02-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-02-02 | 2005-08-04 | 2006-02-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-02-02 | 2009-08-04 | 2010-02-03 | $7700.00 | Window Closed / Lapsed |