US5429582A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tumor treatment
Assignee: Cytyc Corp
•
Filing: 1991-06-14
•
Granted: 1995-07-04
•
Expires: 2011-06-14
Abstract
Abstract A completely implantable apparatus is provided for treatment of tissue surrounding a cavity left by surgical removal of a brain tumor. The apparatus includes an inflatable balloon constructed for placement in the cavity. A subcutaneously implantable treatment fluid receptacle is provided for receiving a transdermal injection of a treatment fluid. A catheter connects the receptacle to the inflatable balloon. Various embodiments provide for simultaneous application of heat therapy and/or radiation therapy and/or chemotherapy to the remaining tissue surrounding the cavity from which the tumor was removed.
Inventors
- 👤 Jeffery A. Williams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 06:38
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/10; A61M25/1011; A61M39/00; A61M39/02; A61M39/0208; A61N; A61N1/00; A61N1/40; A61N1/403; A61N5/00; A61N5/10; A61N5/1001; A61N5/1014; A61N5/1015; A61N7/00; A61N7/02; A61B; A61B17/00; A61B2017/00017; A61B2017/00022; A61B2017/00084; A61M2025/1013; A61M2039/0211; A61M2205/00; A61M2205/32; A61M2210/00; A61M2210/06; A61M2210/0687; A61M2210/0693; A61M27/00; A61M27/002; A61M27/006; A61M39/0247; A61M5/00; A61M5/42; A61M5/427; A61N2005/1019; A61N2005/1021
Claims Analysis
Total Claims: 49
Claim 1
Independent Claim
121 words
A surgical procedure for treating a brain tumor in a living patient, comprising: (a) surgically removing at least a portion of said tumor thereby creating a cavity in the patient's remaining tissue; (b) placing an inflatable treatment device in said cavity; and (c) treating remaining tissue surrounding said cavity by means of said inflatable treatment device by inflating said inflatable treatment device with a treatment fluid so that the inflatable treatment device occupies said cavity thereby placing said treatment fluid in close proximity to said remaining tissue surrounding said cavity said treating including inflating said inflatable treatment device to a volume not substantially greater than a volume of said cavity thereby avoiding any substantial compression or distortion of normal brain tissue.
Claim 2
Dependent Claim
121 words
A surgical procedure for treating a brain tumor in a living patient, comprising: (a) surgically removing at least a portion of said tumor thereby creating a cavity in the patient's remaining tissue; (b) placing an inflatable treatment device in said cavity; and (c) treating remaining tissue surrounding said cavity by means of said inflatable treatment device by inflating said inflatable treatment device with a treatment fluid so that the inflatable treatment device occupies said cavity thereby placing said treatment fluid in close proximity to said remaining tissue surrounding said cavity said treating including inflating said inflatable treatment device to a volume not substantially greater than a volume of said cavity thereby avoiding any substantial compression or distortion of normal brain tissue.
Claim 3
Dependent Claim
22 words
The procedure of claim 1, wherein: said step (c) includes treating said remaining tissue without making further surgical incisions on the patient.
Claim 4
Dependent Claim
32 words
The procedure of claim 1, wherein; said step (c) includes applying radiation to said remaining tissue surrounding said cavity by including radioactive material in said treatment fluid in said inflatable treatment device.
Claim 5
Dependent Claim
49 words
The procedure of claim 1, wherein: said step (c) includes simultaneously applying heat and radiation to said remaining tissue surrounding said cavity by including radioactive material in said treatment fluid in said inflatable treatment device and heating said treatment fluid including said radioactive material in said inflatable treatment device.
Claim 6
Dependent Claim
29 words
The procedure of claim 1, wherein: said step (c) includes simultaneously applying heat and chemotherapy to said remaining tissue surrounding said cavity by means of said inflatable treatment device.
Claim 7
Dependent Claim
29 words
The procedure of claim 1, wherein: said step (c) includes simultaneously applying radiation and chemotherapy to said remaining tissue surrounding said cavity by means of said inflatable treatment device.
Claim 8
Dependent Claim
30 words
The procedure of claim 1, wherein: said step (c) includes simultaneously applying heat, radiation and chemotherapy to said remaining tissue surrounding said cavity by means of said inflatable treatment device.
Claim 9
Dependent Claim
36 words
The procedure of claim 1, wherein: in said step (b) said inflatable treatment device is connected by a catheter to an injection receptacle; and said procedure further includes a step of implanting said injection receptacle subcutaneously.
Claim 10
Dependent Claim
47 words
The procedure of claim 8, wherein; said step (c) includes transdermally injecting a treatment fluid into said subcutaneous injection receptacle, then flowing said treatment fluid from said injection receptacle through said catheter into said inflatable treatment device to inflate said inflatable treatment device with said treatment fluid.
Claim 11
Dependent Claim
14 words
The procedure of claim 9, wherein: said injecting is performed with a hypodermic needle.
Claim 12
Dependent Claim
40 words
The procedure of claim 8, said tumor being a brain tumor, wherein: said implanting of said injection receptacle includes implanting said injection receptacle between the patient's skull and scalp, with said catheter running through a hole in the patient's skull.
Claim 13
Dependent Claim
18 words
The procedure of claim 11, wherein: said injection receptacle is recessed within a counterbore in the patient's skull.
Claim 14
Dependent Claim
16 words
The procedure of claim 12, further comprising: locating said injection receptacle by X-raying the patient's skull.
Claim 15
Dependent Claim
100 words
A surgical procedure for treating a tumor in a living patient, comprising: (a) surgically removing at least a portion of said tumor; and (b) simultaneously applying radiation, heat and chemotherapy treatment to remaining tissue surrounding a location from which said tumor was removed, without making any further surgical incisions on the patient; wherein said step (b) is performed by placing fluid in a distensible catheter implanted during step (a) in said location from which said tumor was removed; and wherein said fluid is placed in said distensible catheter by subcutaneously injecting said fluid into a receptacle communicated with said catheter.
Claim 16
Dependent Claim
100 words
A surgical procedure for treating a tumor in a living patient, comprising: (a) surgically removing at least a portion of said tumor; and (b) simultaneously applying radiation, heat and chemotherapy treatment to remaining tissue surrounding a location from which said tumor was removed, without making any further surgical incisions on the patient; wherein said step (b) is performed by placing fluid in a distensible catheter implanted during step (a) in said location from which said tumor was removed; and wherein said fluid is placed in said distensible catheter by subcutaneously injecting said fluid into a receptacle communicated with said catheter.
Claim 17
Dependent Claim
12 words
The procedure of claim 14, wherein said tumor is a brain tumor.
Claim 18
Dependent Claim
100 words
An implantable apparatus for treatment of tissue surrounding a cavity left by surgical removal of a tumor from a living patient, comprising: an inflatable balloon constructed for placement in said cavity; a treatment fluid receptacle means for receiving a transdermal injection of a treatment fluid; a catheter means, connected between said receptacle means and said balloon, for carrying said treatment fluid from said receptacle means to said inflatable balloon; and heating means, operatively associated with said balloon, for heating said treatment fluid while said treatment fluid is in said balloon and without having any electrical wiring running into said balloon.
Claim 19
Dependent Claim
100 words
An implantable apparatus for treatment of tissue surrounding a cavity left by surgical removal of a tumor from a living patient, comprising: an inflatable balloon constructed for placement in said cavity; a treatment fluid receptacle means for receiving a transdermal injection of a treatment fluid; a catheter means, connected between said receptacle means and said balloon, for carrying said treatment fluid from said receptacle means to said inflatable balloon; and heating means, operatively associated with said balloon, for heating said treatment fluid while said treatment fluid is in said balloon and without having any electrical wiring running into said balloon.
Claim 20
Dependent Claim
34 words
The apparatus of claim 16, further comprising: valve means, connected to said catheter between said balloon and said receptacle means, for controlling flow of said treatment fluid between said receptacle means and said balloon.
Claim 21
Dependent Claim
38 words
The apparatus of claim 16, wherein: said inflatable balloon has an inflated volume no greater than a volume of said cavity and thus comprises a means for avoiding any compression or distortion of normal tissue surrounding said cavity.
Claim 22
Dependent Claim
15 words
The apparatus of claim 16, wherein: said receptacle means is a subcutaneously implantable receptacle means.
Claim 23
Dependent Claim
73 words
The apparatus of claim 16, wherein: said balloon means is a double-walled balloon means having an inner balloon wall received within an outer balloon wall, said inner balloon wall being non-porous for receiving and holding a radioactive fluid in an interior thereof, and said outer balloon wall being porous for receiving a chemotherapy fluid in a space between said inner and outer walls and dispersing said chemotherapy fluid through said porous outer wall.
Claim 24
Dependent Claim
82 words
The apparatus of claim 20, wherein: said receptacle means is a first receptacle means for receiving said radioactive fluid, and said catheter means is a first catheter means connected between said first receptacle means and said interior of said inner balloon wall; and said apparatus further includes: a second treatment fluid receptacle means for receiving a transdermal injection of said chemotherapy fluid; and a second catheter means connected between said second receptacle means and said space between said inner and outer walls.
Claim 25
Dependent Claim
20 words
The apparatus of claim 20, wherein: said balloon means includes a layer of sponge between said inner and outer walls.
Claim 26
Dependent Claim
21 words
The apparatus of claim 16, further comprising: monitoring means for monitoring a temperature of said treatment fluid within said balloon means.
Claim 27
Dependent Claim
35 words
The apparatus of claim 23, wherein: said monitoring means includes a implantable crystal oscillator having a frequency of oscillation related to its temperature and external means for sensing said frequency of oscillation of said oscillator.
Claim 28
Dependent Claim
30 words
The apparatus of claim 16, wherein said heating means comprises: external ultrasonic transmission means for transmitting ultrasonic energy into said treatment fluid in said balloon to heat said treatment fluid.
Claim 29
Dependent Claim
35 words
The apparatus of claim 16, wherein said heating means comprises: external radio frequency electromagnetic energy transmission means for transmitting radio frequency electromagnetic energy into said treatment fluid in said balloon to heat said treatment fluid.
Claim 30
Dependent Claim
79 words
The apparatus of claim 16, wherein: said balloon is filled with said treatment fluid, said treatment fluid including a ferromagnetic material in suspension therein; said heating means includes external radio frequency electromagnetic energy transmission means for transmitting radio frequency electromagnetic energy into said treatment fluid in said balloon to heat said treatment fluid and provide heat therapy to said patient; and said treatment fluid further includes radioactive material so that radiation therapy is provided simultaneously with said heat therapy.
Claim 31
Dependent Claim
116 words
An implantable apparatus for treatment of tissue surrounding a cavity left by surgical removal of a tumor from a living patient, comprising: an inflatable balloon means for filling at least a portion of said cavity; and treatment means, operably associated with said balloon means, for simultaneously applying radiation, heat and chemotherapy treatment to remaining tissue surrounding said cavity without making any further surgical incisions on the patient, wherein said treatment means further includes: a treatment fluid receptacle means for receiving a transdermal injection of a radioactive treatment fluid; and a catheter means, connected between said receptacle means and said balloon means, for carrying said radioactive treatment fluid from said receptacle means to said inflatable balloon means.
Claim 32
Dependent Claim
116 words
An implantable apparatus for treatment of tissue surrounding a cavity left by surgical removal of a tumor from a living patient, comprising: an inflatable balloon means for filling at least a portion of said cavity; and treatment means, operably associated with said balloon means, for simultaneously applying radiation, heat and chemotherapy treatment to remaining tissue surrounding said cavity without making any further surgical incisions on the patient, wherein said treatment means further includes: a treatment fluid receptacle means for receiving a transdermal injection of a radioactive treatment fluid; and a catheter means, connected between said receptacle means and said balloon means, for carrying said radioactive treatment fluid from said receptacle means to said inflatable balloon means.
Claim 33
Dependent Claim
122 words
A treatment apparatus for applying simultaneous heat treatment and radiation treatment to remaining tissue surrounding a cavity left by surgical removal of a tumor from a living body, comprising: a distensible reservoir constructed for placement in said cavity; a treatment fluid filling said distensible reservoir, said reservoir being distended by said treatment fluid so that said treatment fluid is in close proximity to said remaining tissue, said treatment fluid including a mixture of ferromagnetic material and radioactive material; catheter means for conducting said treatment fluid into said reservoir after said reservoir is placed in said cavity; and external radio frequency electromagnetic energy transmission means for transmitting radio frequency electromagnetic energy into said treatment fluid in said reservoir to heat said treatment fluid.
Claim 34
Dependent Claim
122 words
A treatment apparatus for applying simultaneous heat treatment and radiation treatment to remaining tissue surrounding a cavity left by surgical removal of a tumor from a living body, comprising: a distensible reservoir constructed for placement in said cavity; a treatment fluid filling said distensible reservoir, said reservoir being distended by said treatment fluid so that said treatment fluid is in close proximity to said remaining tissue, said treatment fluid including a mixture of ferromagnetic material and radioactive material; catheter means for conducting said treatment fluid into said reservoir after said reservoir is placed in said cavity; and external radio frequency electromagnetic energy transmission means for transmitting radio frequency electromagnetic energy into said treatment fluid in said reservoir to heat said treatment fluid.
Claim 35
Dependent Claim
32 words
The apparatus of claim 29, further comprising: a subcutaneously implantable treatment fluid receptacle means for receiving a transdermal injection of said treatment fluid, said receptacle means being connected to said catheter means.
Claim 36
Dependent Claim
20 words
The apparatus of claim 29, further comprising: monitoring means for monitoring a temperature of said treatment fluid within said reservoir.
Claim 37
Dependent Claim
26 words
The apparatus of claim 31, wherein: said monitoring means includes an implantable crystal oscillator and external means for sensing a frequency of oscillation of said oscillator.
Claim 38
Dependent Claim
127 words
An implantable apparatus for treatment of tissue surrounding a cavity left by surgical removal of a tumor from a living patient, comprising: an inflatable balloon constructed for placement in said cavity; a treatment fluid receptacle means for receiving a transdermal injection of a treatment fluid, said receptacle means being at least in part impenetrable by X-rays and being constructed to be countersunk within the patient's skull; a catheter means connected between said receptacle means and said balloon, for carrying said treatment fluid from said receptacle means to said inflatable balloon; and a metallic grid constructed to be temporarily attached to the patient's scalp overlying the receptacle means to permit determination of the location of said receptacle means relative to said metallic grid by X-raying the patient's skull.
Claim 39
Dependent Claim
127 words
An implantable apparatus for treatment of tissue surrounding a cavity left by surgical removal of a tumor from a living patient, comprising: an inflatable balloon constructed for placement in said cavity; a treatment fluid receptacle means for receiving a transdermal injection of a treatment fluid, said receptacle means being at least in part impenetrable by X-rays and being constructed to be countersunk within the patient's skull; a catheter means connected between said receptacle means and said balloon, for carrying said treatment fluid from said receptacle means to said inflatable balloon; and a metallic grid constructed to be temporarily attached to the patient's scalp overlying the receptacle means to permit determination of the location of said receptacle means relative to said metallic grid by X-raying the patient's skull.
Claim 40
Dependent Claim
150 words
A chemotherapy apparatus for treatment of remaining tissue surrounding a cavity left by surgical removal of a tumor from a living body, comprising: a distensible reservoir including a porous outer wall and a non-porous inner wall arranged so that a space is defined between said inner and outer walls, and so that an interior is defined within said inner wall; a first catheter means connected to said space between said inner and outer walls for conducting a chemotherapy fluid into said space; sponge means disposed in said space between said inner and outer walls for temporarily holding said chemotherapy fluid; a second catheter means connected to said interior within said inner wall for conducting a second fluid into said interior; and first and second subcutaneously implantable fluid receptacle means, connected to said first and second catheter means, for receiving transdermal injections of said chemotherapy fluid and said second fluid, respectively.
Claim 41
Dependent Claim
150 words
A chemotherapy apparatus for treatment of remaining tissue surrounding a cavity left by surgical removal of a tumor from a living body, comprising: a distensible reservoir including a porous outer wall and a non-porous inner wall arranged so that a space is defined between said inner and outer walls, and so that an interior is defined within said inner wall; a first catheter means connected to said space between said inner and outer walls for conducting a chemotherapy fluid into said space; sponge means disposed in said space between said inner and outer walls for temporarily holding said chemotherapy fluid; a second catheter means connected to said interior within said inner wall for conducting a second fluid into said interior; and first and second subcutaneously implantable fluid receptacle means, connected to said first and second catheter means, for receiving transdermal injections of said chemotherapy fluid and said second fluid, respectively.
Claim 42
Dependent Claim
128 words
A surgical procedure for treating a tumor in a living patient, comprising: (a) surgically removing at least a portion of said tumor thereby creating a cavity in the patient's remaining tissue; (b) placing an inflatable treatment device in said cavity; and (c) treating remaining tissue surrounding said cavity by means of said inflatable treatment device by inflating said inflatable treatment device with a treatment fluid so that the inflatable device occupies said cavity thereby placing said treatment fluid in close proximity to said remaining tissue surrounding said cavity, said treating step including applying heat to said remaining tissue surrounding said cavity by heating said treatment fluid while said treatment fluid is contained in said inflatable treatment device without having any electrical wiring running into said inflatable treatment device.
Claim 43
Dependent Claim
128 words
A surgical procedure for treating a tumor in a living patient, comprising: (a) surgically removing at least a portion of said tumor thereby creating a cavity in the patient's remaining tissue; (b) placing an inflatable treatment device in said cavity; and (c) treating remaining tissue surrounding said cavity by means of said inflatable treatment device by inflating said inflatable treatment device with a treatment fluid so that the inflatable device occupies said cavity thereby placing said treatment fluid in close proximity to said remaining tissue surrounding said cavity, said treating step including applying heat to said remaining tissue surrounding said cavity by heating said treatment fluid while said treatment fluid is contained in said inflatable treatment device without having any electrical wiring running into said inflatable treatment device.
Claim 44
Dependent Claim
117 words
A surgical procedure for treating a tumor in a living patient, comprising: (a) surgically removing at least a portion of said tumor thereby creating a cavity in the patient's remaining tissue; (b) placing an inflatable treatment device in said cavity, said treatment device being connected by a catheter to an injection receptacle; (c) implanting said injection receptacle subcutaneously; (d) locating said injection receptacle by X-raying the patient's body; and (e) treating remaining tissue surrounding said cavity by means of said inflatable treatment device by inflating said inflatable treatment device with a treatment fluid so that the inflatable treatment device occupies said cavity thereby placing said treatment fluid in close proximity to said remaining tissue surrounding said cavity.
Claim 45
Dependent Claim
117 words
A surgical procedure for treating a tumor in a living patient, comprising: (a) surgically removing at least a portion of said tumor thereby creating a cavity in the patient's remaining tissue; (b) placing an inflatable treatment device in said cavity, said treatment device being connected by a catheter to an injection receptacle; (c) implanting said injection receptacle subcutaneously; (d) locating said injection receptacle by X-raying the patient's body; and (e) treating remaining tissue surrounding said cavity by means of said inflatable treatment device by inflating said inflatable treatment device with a treatment fluid so that the inflatable treatment device occupies said cavity thereby placing said treatment fluid in close proximity to said remaining tissue surrounding said cavity.
Claim 46
Dependent Claim
116 words
An implantable apparatus for treatment of tissue surrounding a cavity left by surgical removal of a tumor from a living patient, comprising: an inflatable balloon means for filling at least a portion of said cavity, said balloon means being a double-walled balloon means having an inner balloon wall received within an outer balloon wall, said outer balloon wall being porous thus providing a means for dispersing through said porous outer wall a chemotherapy fluid received in a space between said inner and outer walls; and treatment means, operably associated with said balloon means, for simultaneously applying radiation, heat and chemotherapy treatment to remaining tissue surrounding said cavity without making any further surgical incisions on the patient.
Claim 47
Dependent Claim
116 words
An implantable apparatus for treatment of tissue surrounding a cavity left by surgical removal of a tumor from a living patient, comprising: an inflatable balloon means for filling at least a portion of said cavity, said balloon means being a double-walled balloon means having an inner balloon wall received within an outer balloon wall, said outer balloon wall being porous thus providing a means for dispersing through said porous outer wall a chemotherapy fluid received in a space between said inner and outer walls; and treatment means, operably associated with said balloon means, for simultaneously applying radiation, heat and chemotherapy treatment to remaining tissue surrounding said cavity without making any further surgical incisions on the patient.
Claim 48
Dependent Claim
119 words
An implantable apparatus for treatment of tissue surrounding a cavity left by surgical removal of a tumor from a living patient, comprising: an inflatable balloon means for filling at least a portion of said cavity; and treatment means, operably associated with said balloon means, for simultaneously applying radiation, heat and chemotherapy treatment to remaining tissue surrounding said cavity without making any further surgical incisions on the patient, said treatment means further including: means for filling said balloon means with a treatment fluid; heating means, operatively associated with said balloon means, for heating said treatment while said treatment fluid is contained in said balloon means; and monitoring means for monitoring a temperature of said treatment fluid within said balloon means.
Claim 49
Dependent Claim
119 words
An implantable apparatus for treatment of tissue surrounding a cavity left by surgical removal of a tumor from a living patient, comprising: an inflatable balloon means for filling at least a portion of said cavity; and treatment means, operably associated with said balloon means, for simultaneously applying radiation, heat and chemotherapy treatment to remaining tissue surrounding said cavity without making any further surgical incisions on the patient, said treatment means further including: means for filling said balloon means with a treatment fluid; heating means, operatively associated with said balloon means, for heating said treatment while said treatment fluid is contained in said balloon means; and monitoring means for monitoring a temperature of said treatment fluid within said balloon means.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-07-03 | 1999-01-02 | 1999-07-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-07-03 | 2003-01-02 | 2003-07-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-07-03 | 2007-01-02 | 2007-07-04 | $7700.00 | Window Closed / Lapsed |