US5709742A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Reactive tricalcium phosphate compositions
Assignee: KNC NOR Acquisition Sub Inc
•
Filing: 1996-05-15
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Granted: 1998-01-20
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Expires: 2016-05-15
Abstract
Abstract Methods for producing a room temperature stable, phase pure alpha -C3P product, and compositions derived therefrom, are provided. In the subject method, a tricalcium phosphate source is heated to a temperature sufficient to convert substantially all of said tricalcium phosphate source to a substantially phase pure alpha -C3P product. The temperature of the resultant product is rapidly cooled to a temperature below about 700 DEG C., resulting in a room temperature stable, reactive alpha -C3P product. The resultant alpha -C3P product may be milled to provide an alpha -C3P composition which may find use in the preparation of calcium phosphate cements.
Inventors
- 👤 Mark Fulmer
- 👤 Brent R. Constantz
- 👤 Ira C. Ison
- 👤 Bryan M. Barr
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 22:33
CPC Classifications
C; C01; C01B; C01B25/00; C01B25/16; C01B25/26; C01B25/32; A; A61; A61L; A61L24/00; A61L24/02; A61L27/00; A61L27/02; A61L27/12; C01B25/321; C04; C04B; C04B12/00; C04B12/02; C04B12/025; C04B28/00; C04B28/34; C04B28/344; C04B28/346; A61F; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293; A61L2430/00; A61L2430/38; C04B2111/00; C04B2111/00474; C04B2111/00836
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
90 words
A calcium phosphate cement formulation for use in the preparation of a calcium phosphate mineral by combining dry ingredients of said cement with a lubricant to produce a kneadable product capable of setting into said calcium phosphate mineral in less than 10 minutes, said formulation comprising as dry ingredients: reactive tricalcium phosphate consisting of particles having a mean diameter of 3 to 5 μm and a surface area ranging from about 2.5 to 3.5 m 2 /gm; at least one additional calcium source; and a partially neutralized phosphoric acid source.
Claim 2
Dependent Claim
90 words
A calcium phosphate cement formulation for use in the preparation of a calcium phosphate mineral by combining dry ingredients of said cement with a lubricant to produce a kneadable product capable of setting into said calcium phosphate mineral in less than 10 minutes, said formulation comprising as dry ingredients: reactive tricalcium phosphate consisting of particles having a mean diameter of 3 to 5 μm and a surface area ranging from about 2.5 to 3.5 m 2 /gm; at least one additional calcium source; and a partially neutralized phosphoric acid source.
Claim 3
Dependent Claim
17 words
The cement formulation according to claim 1, wherein said reactive tricalcium phosphate comprises particles of α-tricalcium phosphate.
Claim 4
Dependent Claim
19 words
The cement formulation according to claim 1, wherein said at least one additional calcium source is CaCO 3 .
Claim 5
Dependent Claim
24 words
The cement formulation according to claim 1, wherein said partially neutralized phosphoric acid source is Ca(H 2 PO 4 ) 2 ·H 2 O.
Claim 6
Dependent Claim
16 words
A kit comprising the calcium phosphate cement formulation of claim 1 and a physiologically compatible lubricant.
Claim 7
Dependent Claim
21 words
The kit according to claim 5, wherein said physiologically compatible lubricant is an aqueous solution of Na 2 HPO 4 .
Claim 8
Dependent Claim
87 words
A calcium phosphate cement formulation for use in the preparation of a calcium phosphate mineral by combining dry ingredients of said cement with a lubricant to produce a kneadable product capable of setting into said calcium phosphate mineral in less than 10 minutes, said formulation comprising as dry ingredients: reactive α-tricalcium phosphate consisting of particles having a mean diameter of 3 to 5 μm and a surface area ranging from about 2.5 to 3.5 m 2 /gm; CaCo 3 ; Ca(H 2 PO 4 )·H 2 O.
Claim 9
Dependent Claim
87 words
A calcium phosphate cement formulation for use in the preparation of a calcium phosphate mineral by combining dry ingredients of said cement with a lubricant to produce a kneadable product capable of setting into said calcium phosphate mineral in less than 10 minutes, said formulation comprising as dry ingredients: reactive α-tricalcium phosphate consisting of particles having a mean diameter of 3 to 5 μm and a surface area ranging from about 2.5 to 3.5 m 2 /gm; CaCo 3 ; Ca(H 2 PO 4 )·H 2 O.
Claim 10
Dependent Claim
24 words
The cement formulation according to claim 7, wherein said CaCO 3 is present in from about 2 to 40 weight % of said formulation.
Claim 11
Dependent Claim
31 words
The cement formulation according to claim 7, wherein said Ca(H 2 PO 4 ) 2 ·H 2 O is present in from about 1 to 40 weight % of said formulation.
Claim 12
Dependent Claim
115 words
A calcium phosphate cement formulation for use in the preparation of a calcium phosphate mineral by combining dry ingredients of said cement with a lubricant to produce a kneadable product capable of setting into said calcium phosphate mineral in less than 10 minutes, said formulation comprising as dry ingredients: reactive α-tricalcium phosphate consisting of particles having a mean diameter of 3 to 5 μm and a surface area ranging from about 2.5 to 3.5 m 2 /gm; CaCO 3 ; Ca(H 2 PO 4 )·H 2 O; wherein the molar ratio of said reactive α-tricalcium phosphate to said CaCO 3 to said Ca(H 2 PO 4 )·H 2 O is 0.048 to 0.0185 to 0.00196.
Claim 13
Dependent Claim
115 words
A calcium phosphate cement formulation for use in the preparation of a calcium phosphate mineral by combining dry ingredients of said cement with a lubricant to produce a kneadable product capable of setting into said calcium phosphate mineral in less than 10 minutes, said formulation comprising as dry ingredients: reactive α-tricalcium phosphate consisting of particles having a mean diameter of 3 to 5 μm and a surface area ranging from about 2.5 to 3.5 m 2 /gm; CaCO 3 ; Ca(H 2 PO 4 )·H 2 O; wherein the molar ratio of said reactive α-tricalcium phosphate to said CaCO 3 to said Ca(H 2 PO 4 )·H 2 O is 0.048 to 0.0185 to 0.00196.
Claim 14
Dependent Claim
21 words
A kit comprising the calcium phosphate cement formulation of claim 10 and an aqueous solution of Na 2 HPO 4 .
Claim 15
Dependent Claim
24 words
A kneadable product capable of setting into a solid mass comprising the cement formulation of claim 10 in combination with a physiologically compatible lubricant.
Claim 16
Dependent Claim
22 words
The kneadable product according to claim 12, wherein said physiologically compatible lubricant is an aqueous solution of Na 2 HPO 4 .
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-01-19 | 2001-07-21 | 2002-01-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-01-19 | 2005-07-21 | 2006-01-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-01-19 | 2009-07-21 | 2010-01-20 | $7700.00 | Window Closed / Lapsed |