US5708002A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Macrocyclic immunomodulators
Assignee: Abbott Laboratories
•
Filing: 1996-10-23
•
Granted: 1998-01-13
•
Expires: 2016-10-23
Abstract
Abstract Immunomodulatory macrocyclic compounds having the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is selected from one of the formulae ##STR2## as well as pharmaceutical compositions containing the same.
Inventors
- 👤 Jay R. Luly
- 👤 Megumi Kawai
- 👤 Yat Sun Or
- 👤 Paul Wiedeman
- 👤 Rolf Wagner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:34
CPC Classifications
C; C07; C07D; C07D498/00; C07D498/12; C07D498/18
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
84 words
A compound of the formula: ##STR18## wherein X is ##STR19## and (a) R=ethyl; R'=R2=R3=H; n=1; R 1' =--OCH 3 ; and R 1 =CH 3 C(O)S-- (S Configuration); or (b) R=ethyl; R'=R2=R3=H; n=1; R 1' =--OCH 3 ; and R 1 =C 6 H 5 S--; or (c) R=ethyl; R'=R2=R3=H; n=1; R 1' =--OCH 3 ; and R 1 =benzylthio; or (d) R=ethyl; R'=R2=R3=H; n=1; R 1' =--OCH 3 ; and R 1 =--SH; or a pharmaceutically acceptable salt, ester, amide or prodrug thereof.
Claim 2
Dependent Claim
84 words
A compound of the formula: ##STR18## wherein X is ##STR19## and (a) R=ethyl; R'=R2=R3=H; n=1; R 1' =--OCH 3 ; and R 1 =CH 3 C(O)S-- (S Configuration); or (b) R=ethyl; R'=R2=R3=H; n=1; R 1' =--OCH 3 ; and R 1 =C 6 H 5 S--; or (c) R=ethyl; R'=R2=R3=H; n=1; R 1' =--OCH 3 ; and R 1 =benzylthio; or (d) R=ethyl; R'=R2=R3=H; n=1; R 1' =--OCH 3 ; and R 1 =--SH; or a pharmaceutically acceptable salt, ester, amide or prodrug thereof.
Claim 3
Dependent Claim
19 words
The compound according to claim 1 wherein R=ethyl; R'=R2=R3=H; n=1; R 1' =--OCH 3 ; and R 1 =--SH.
Claim 4
Dependent Claim
33 words
A compound of the formula: ##STR20## wherein X is ##STR21## and R=ethyl; R'=R2=R3=H; n=1; R 1' =--OCH 3 ; R 1 =N-tetrazole (S-Configuration); or a pharmaceutically acceptable salt, ester, amide or prodrug thereof.
Claim 5
Dependent Claim
33 words
A compound of the formula: ##STR20## wherein X is ##STR21## and R=ethyl; R'=R2=R3=H; n=1; R 1' =--OCH 3 ; R 1 =N-tetrazole (S-Configuration); or a pharmaceutically acceptable salt, ester, amide or prodrug thereof.
Claim 6
Dependent Claim
24 words
A method for providing immunomodulatory treatment comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claim 1.
Claim 7
Dependent Claim
24 words
A method for providing immunomodulatory treatment comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claim 3.
Claim 8
Dependent Claim
24 words
A pharmaceutical composition for immunomodulatory treatment comprising a therapeutically effective amount of a compound of claim 1 in combination with a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
24 words
A pharmaceutical composition for immunomodulatory treatment comprising a therapeutically effective amount of a compound of claim 3 in combination with a pharmaceutically acceptable carrier.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-01-12 | 2001-07-14 | 2002-01-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-01-12 | 2005-07-14 | 2006-01-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-01-12 | 2009-07-14 | 2010-01-13 | $7700.00 | Window Closed / Lapsed |