US5705062A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Analytical device for separating magnetic microparticles from suspensions
Assignee: Roche Diagnostics Corp
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Filing: 1994-09-07
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Granted: 1998-01-06
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Expires: 2014-09-07
Abstract
Abstract An analytical device separates magnetic microparticles from a suspension. The separating portion of the device contains two permanent magnets between which the reaction vessel containing the suspension is disposed. For the purpose of more rapid, complete separation of the magnetic microparticles, magnets are positioned diametrically opposite one another relative to the reaction vessel. The polar axes of the magnets and the longitudinal axis of the reaction vessel include an acute angle.
Inventors
- 👤 Rolf Knobel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 16:37
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54313; G01N33/54326; B; B03; B03C; B03C1/00; B03C1/005; B03C1/01; B03C1/02; B03C1/025; B03C1/031; B03C1/033; B03C1/0332; B03C1/28; B03C1/288; B03C2201/00; B03C2201/18; B03C2201/26; G01N35/00; G01N35/02; G01N35/04; G01N2035/0474; G01N2035/0482; G01N2035/0484; G01N35/0098; G01N35/025; G01N35/10; G01N35/1081; G01N35/109
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
172 words
An analytical device which comprises: (a) a reaction vessel having an elongated body with a longitudinal portion, a closed base and a longitudinal axis of symmetry, the reaction vessel containing a suspension of magnetic microparticles in solution, the suspension having a free surface; and (b) at least one receiving station having means for receiving the reaction vessel and means for separating the magnetic microparticles from the solution when the reaction vessel is received by the receiving station, the means for separating the magnetic microparticles comprising a pair of magnets, each magnet in the pair being diametrically opposite to the other magnet in the pair and arranged so that the longitudinal portion of the reaction vessel when received by the receiving station is located between the magnets, each of the magnets having a polar axis which intersects with the polar axis of the other magnet at a point on the longitudinal axis of the reaction vessel, each of the polar axes forming an acute angle with the longitudinal axis of the reaction vessel.
Claim 2
Dependent Claim
172 words
An analytical device which comprises: (a) a reaction vessel having an elongated body with a longitudinal portion, a closed base and a longitudinal axis of symmetry, the reaction vessel containing a suspension of magnetic microparticles in solution, the suspension having a free surface; and (b) at least one receiving station having means for receiving the reaction vessel and means for separating the magnetic microparticles from the solution when the reaction vessel is received by the receiving station, the means for separating the magnetic microparticles comprising a pair of magnets, each magnet in the pair being diametrically opposite to the other magnet in the pair and arranged so that the longitudinal portion of the reaction vessel when received by the receiving station is located between the magnets, each of the magnets having a polar axis which intersects with the polar axis of the other magnet at a point on the longitudinal axis of the reaction vessel, each of the polar axes forming an acute angle with the longitudinal axis of the reaction vessel.
Claim 3
Dependent Claim
13 words
The device according to claim 1, wherein the acute angle is about 45°.
Claim 4
Dependent Claim
26 words
The device according to claim 1, wherein the magnets are connected to a holder having a groove into which the base of the reaction vessel projects.
Claim 5
Dependent Claim
48 words
The device according to claim 1, wherein the magnets each have a top surface and are disposed so that the top surface of each magnet lies below the free surface of the suspension, the polar axes of the two magnets intersecting at the free surface of the suspension.
Claim 6
Dependent Claim
67 words
The device according to claim 1, wherein the magnets each have a north pole and a south pole, and are disposed so that the north pole of one of the magnets and the south pole of the diametrically opposite magnet lie near the base of the reaction vessel, the polar axes of the diametrically opposite magnets intersection with each other near the base of the reaction vessel.
Claim 7
Dependent Claim
43 words
The device according to claim 1, wherein the device comprises from about 1 to about 20 receiving stations disposed on a circular rotor magazine, and the pair of magnets of each receiving station is radially disposed with respect to the circular rotor magazine.
Claim 8
Dependent Claim
114 words
The device according to claim 6, wherein the rotor magazine is a part of a washing device, the washing device comprising (i) at least one processing station for separating a solid from a liquid; (ii) at least one processing station for aspirating a liquid; and (iii) at least one processing station for suspending a solid within a liquid, each processing station containing the receiving station including two of the diametrically opposite magnets each having a top surface and being disposed so that the top surface of each magnet lies below the free surface of the suspension, the polar axes of the two magnets intersecting with each other at the free surface of the suspension.
Claim 9
Dependent Claim
59 words
The device according to claim 7, wherein the pair of magnets of the first receiving station is disposed along a first radius, the pair of magnets of the second receiving station in the immediate vicinity of the first receiving station is disposed along a second radius, and the first and second radii form an acute angle with each other.
Claim 10
Dependent Claim
13 words
The device according to claim 8, wherein the acute angle is about 20°.
Claim 11
Dependent Claim
140 words
The device according to claim 6, wherein the rotor magazine is a part of a washing device, the washing device comprising (i) at least one processing station for separating a solid from a liquid; (ii) at least one processing station for aspirating a liquid; and (iii) at least one processing station for suspending a solid within a liquid, each processing station containing the receiving station for separating the magnetic microparticles from solution, each receiving station including two of the diametrically opposite magnets each having a north pole and a south pole, the magnets being disposed so that the north pole of one of the magnets and the south pole of the diametrically opposite magnet lie near the base of the reaction vessel, the polar axes of the two magnets intersecting with each other near the base of the reaction vessel.
Claim 12
Dependent Claim
59 words
The device according to claim 10, wherein the pair of magnets of the first receiving station is disposed along a first radius, the pair of magnets of the second receiving station in the immediate vicinity of the first receiving station is disposed along a second radius, and the first and second radii form an acute angle with each other.
Claim 13
Dependent Claim
13 words
The device according to claim 11, wherein the acute angle is about 20°.
Claim 14
Dependent Claim
59 words
The device according to claim 6, wherein the pair of magnets of the first receiving station is disposed along a first radius, the pair of magnets of the second receiving station in the immediate vicinity of the first receiving station is disposed along a second radius, and the first and second radii form an acute angle with each other.
Claim 15
Dependent Claim
13 words
The device according to claim 13, wherein the acute angle is about 20°.
Claim 16
Dependent Claim
63 words
The device according to claim 6, wherein the rotor magazine is rotatably mounted on a shaft, and wherein the device further comprises a driving motor connected to the shaft by a toothed belt, and means for cyclically actuating the driving motor, so that when the driving motor is actuated in a cyclic manner each reaction vessel comes to rest in each receiving station.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-01-05 | 2001-07-07 | 2002-01-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-01-05 | 2005-07-07 | 2006-01-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-01-05 | 2009-07-07 | 2010-01-06 | $7700.00 | Window Closed / Lapsed |