Patent US5704345A successfully refreshed from Google Patents.
US5704345A
Expired / Lapsed
US
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Detection of apnea and obstruction of the airway in the respiratory system
Assignee: Resmed Pty Ltd
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Filing: 1994-11-04
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Granted: 1998-01-06
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Expires: 2014-11-04
Abstract
Abstract Methods and apparatus for determining the occurrence of an apnea, patency and/or partial obstruction of the airway are disclosed. Respiratory air flow from a patient is measured to give an air flow signal. The determination of an apnea is performed by calculating the variance of the air flow signal over a moving time window and comparing the variance with a threshold value. One determination of partial obstruction of the airway is performed by detecting the inspiratory part of the air flow signal, scaling it to unity duration and area and calculating an index value of the amplitude of the scaled signal over a mid-portion. Alternatively, the index value is a measure of the flatness of the air flow signal over the mid-portion. One determination of patency of the airway is performed by applying an oscillatory pressure waveform of known frequency to a patient's airway, calculating the magnitude of the component of said air flow signal at the known frequency induced by the oscillatory pressure waveform and comparing the calculated magnitude with a threshold value. Alternatively, the air flow signal is analysed to detect the presence of a component due to cardiogenic activity.
Inventors
- 👤 Michael Berthon-Jones
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 08:27
CPC Classifications
A; A61; A61F; A61F5/00; A61F5/56; A61B; A61B5/00; A61B5/08; A61B5/087; A61M; A61M16/00; A61M16/0003; A61M16/0006; A61M16/0057; A61M16/0066; A61M16/0069; A61M16/021; A61M16/022; A61M16/024; A61M16/026; A61B5/72; A61B5/7235; A61B5/7253; A61B5/7257; A61M2016/003; A61M2016/0033; A61M2016/0039; A61M2205/00; A61M2205/15; A61M2230/00; A61M2230/04; A61M2230/60; Y; Y02; Y02A; Y02A90/00; Y02A90/10
Claims Analysis
Total Claims: 56
Claim 1
Independent Claim
54 words
A method for detecting partial obstruction of the airway of a patient, the method comprising the steps of: measuring patient respiratory air flow; detecting the inspiratory part of said air flow; normalizing said inspiratory part; and determining an index value of a mid-portion of said normalized inspiratory part as a measure of partial obstruction.
Claim 2
Independent Claim
54 words
A method for detecting partial obstruction of the airway of a patient, the method comprising the steps of: measuring patient respiratory air flow; detecting the inspiratory part of said air flow; normalizing said inspiratory part; and determining an index value of a mid-portion of said normalized inspiratory part as a measure of partial obstruction.
Claim 3
Dependent Claim
26 words
The method of claim 1, wherein said normalizing includes scaling said inspiratory part to unity duration and to unity area with respect to amplitude and duration.
Claim 4
Dependent Claim
15 words
The method of claim 1, wherein said determination is performed over a plurality of breaths.
Claim 5
Dependent Claim
30 words
The method of claim 1, comprising the further step of either commencing CPAP treatment or increasing CPAP treatment pressure to the patient if partial obstruction of the airway is detected.
Claim 6
Dependent Claim
22 words
The method of claim 1, wherein said index value is determined from the amplitude of said mid-portion of said normalized inspiratory part.
Claim 7
Dependent Claim
22 words
The method of claim 5, wherein said index value is determined as the arithmetic mean value of said amplitude in said mid-portion.
Claim 8
Dependent Claim
22 words
The method of claim 1, wherein said index value is determined from: the flatness of said mid-portion of said normalized inspiratory part.
Claim 9
Dependent Claim
30 words
The method of claim 7, wherein said index value is determined as the root mean square (RMS) deviation of said normalized inspiratory part in said mid-portion with respect to unity.
Claim 10
Independent Claim
18 words
The method of claims 1 to 4, whereby said measuring step measures respiratory air flow continuously with time.
Claim 11
Independent Claim
20 words
The method of claims 1 to 4, whereby said measuring step samples respiratory air flow at discrete instants in time.
Claim 12
Independent Claim
19 words
The method of claims 1 to 4, whereby said mid-portion is the middle half of said normalized inspiratory part.
Claim 13
Independent Claim
74 words
A method of detecting partial obstruction of the airway of a patient, the method comprising the steps of: measuring patient respiratory air flow; detecting the inspiratory parts of said air flow; normalizing each said inspiratory part by scaling to unity duration, and to unity area with respect to amplitude and duration; and determining an index value of a mid-portion of one or more of said normalized inspiratory parts as a measure of partial obstruction.
Claim 14
Independent Claim
74 words
A method of detecting partial obstruction of the airway of a patient, the method comprising the steps of: measuring patient respiratory air flow; detecting the inspiratory parts of said air flow; normalizing each said inspiratory part by scaling to unity duration, and to unity area with respect to amplitude and duration; and determining an index value of a mid-portion of one or more of said normalized inspiratory parts as a measure of partial obstruction.
Claim 15
Dependent Claim
34 words
The method of claim 12, comprising the further step selected from the steps consisting of commencing CPAP treatment or increasing CPAP treatment pressure to a patient if partial obstruction of the airway is detected.
Claim 16
Dependent Claim
18 words
The method of claim 12, whereby said measuring step samples respiratory air flow at discrete instants in time.
Claim 17
Dependent Claim
28 words
The method of claim 14, whereby said index value is determined from the arithmetic mean of the scaled amplitude of said air flow samples in each said mid-portion.
Claim 18
Dependent Claim
34 words
The method of claim 14, whereby said index value is determined as the root mean square deviation of the scaled amplitude of said air flow samples in each said mid-portion with respect to unity.
Claim 19
Independent Claim
19 words
The method of claims 15 or 16, whereby said mid-portion is the middle half of each said inspiratory part.
Claim 20
Independent Claim
84 words
An apparatus for detecting partial obstruction of the airway of a patient, the apparatus comprising: air flow measurement means for measuring patient respiratory air flow; data processing means coupled to said measurement means to receive said measured air flow, and having a plurality of processing elements including; a detection element for detecting the inspiratory parts of said air flow; and a computational means for determining an index value of a mid-portion of at least one said inspiratory part as a measure of partial obstruction.
Claim 21
Independent Claim
84 words
An apparatus for detecting partial obstruction of the airway of a patient, the apparatus comprising: air flow measurement means for measuring patient respiratory air flow; data processing means coupled to said measurement means to receive said measured air flow, and having a plurality of processing elements including; a detection element for detecting the inspiratory parts of said air flow; and a computational means for determining an index value of a mid-portion of at least one said inspiratory part as a measure of partial obstruction.
Claim 22
Dependent Claim
38 words
The apparatus of claim 18, further for determining patency of said airway, said data processing means further including detection means for detecting the presence of cardiogenic components in said air flow to determine that said airway is patent.
Claim 23
Dependent Claim
63 words
The apparatus of claim 18, further for determining the occurrence of an apnea, and wherein said computational means further determines the variance of said measured air flow, and said data processing means further includes a comparing element to compare said variance with a predetermined threshold value, and if said variance fails below said threshold value it is determined that an apnea is occurring.
Claim 24
Dependent Claim
20 words
The apparatus of claim 20, wherein said computational means determines said variance as a moving average over a time window.
Claim 25
Dependent Claim
38 words
The apparatus of claim 20, further for determining patency of said airway, said data processing means further including detection means for detecting the presence of cardiogenic components in said air flow to determine that said airway is patent.
Claim 26
Dependent Claim
30 words
The apparatus of claim 18, further wherein said computational means normalizes each said inspiratory part by scaling to unity duration, and to unity area with respect to amplitude and duration.
Claim 27
Dependent Claim
25 words
The apparatus of claim 23, wherein said data processing means further comprises a sampling element for sampling said air flow at discrete instants in time.
Claim 28
Dependent Claim
30 words
The apparatus of claim 21, wherein said computational means determines said index value from the arithmetic mean of the scaled amplitude of said air flow samples in each said mid-portion.
Claim 29
Dependent Claim
32 words
The apparatus of claim 24, wherein said computational means determines said index value from the root mean square deviation of said air flow samples in each said mid-portion with respect to unity.
Claim 30
Independent Claim
24 words
The apparatus of claims 25 or 26, wherein said computational means determines the index value from the middle half of each said inspiratory part.
Claim 31
Dependent Claim
22 words
The apparatus of claim 27, wherein said computational means averages the determined index value for each breath over two or more breaths.
Claim 32
Independent Claim
66 words
A method of determining patency of the airway of a patient, the method comprising the steps of: measuring respiratory air flow from the patient wherein the respiratory air flow is high pass filtered to reject components due to respiration; and analyzing said measured air flow to detect the presence of cardiogenic air flow, and if cardiogenic air flow is present then the airway is declared patent.
Claim 33
Independent Claim
66 words
A method of determining patency of the airway of a patient, the method comprising the steps of: measuring respiratory air flow from the patient wherein the respiratory air flow is high pass filtered to reject components due to respiration; and analyzing said measured air flow to detect the presence of cardiogenic air flow, and if cardiogenic air flow is present then the airway is declared patent.
Claim 34
Dependent Claim
18 words
A method as claimed in claim 29, wherein said analysing step detects the presence of a periodic component.
Claim 35
Dependent Claim
22 words
A method as claimed in claim 30, wherein said analysing step further includes performing a Fourier transformation on said air flow signal.
Claim 36
Independent Claim
49 words
A method for detecting partial obstruction of the airway of a patient, the method comprising the steps of: measuring patient respiratory air flow; detecting the inspiratory part of said air flow; and determining an index value of a mid-portion of said inspiratory part as a measure of partial obstruction.
Claim 37
Independent Claim
49 words
A method for detecting partial obstruction of the airway of a patient, the method comprising the steps of: measuring patient respiratory air flow; detecting the inspiratory part of said air flow; and determining an index value of a mid-portion of said inspiratory part as a measure of partial obstruction.
Claim 38
Dependent Claim
21 words
The method of claim 32, wherein said index value is determined from the flatness of said mid-portion of said inspiratory part.
Claim 39
Independent Claim
82 words
A method for determining the degree of patency of the airway of a patient, the method comprising the steps of: applying an oscillatory pressure waveform of known frequency and magnitude to the patient's airway; measuring respiratory air flow from the patient; determining the magnitude of the component of said air flow at said known frequency induced by said oscillatory pressure waveform; and determining the degree of patency as the ratio of said induced air flow magnitude and said oscillatory pressure waveform magnitude.
Claim 40
Independent Claim
82 words
A method for determining the degree of patency of the airway of a patient, the method comprising the steps of: applying an oscillatory pressure waveform of known frequency and magnitude to the patient's airway; measuring respiratory air flow from the patient; determining the magnitude of the component of said air flow at said known frequency induced by said oscillatory pressure waveform; and determining the degree of patency as the ratio of said induced air flow magnitude and said oscillatory pressure waveform magnitude.
Claim 41
Dependent Claim
60 words
Apparatus for detecting partial obstruction of the airway of a patient, the apparatus comprising: means for measuring respiratory air flow from the patient; means for detecting the inspiratory part of said air flow; means for normalising said inspiratory part; and means for determining an index value of a mid-portion of said normalised inspiratory part as a measure of partial obstruction.
Claim 42
Dependent Claim
60 words
Apparatus for detecting partial obstruction of the airway of a patient, the apparatus comprising: means for measuring respiratory air flow from the patient; means for detecting the inspiratory part of said air flow; means for normalising said inspiratory part; and means for determining an index value of a mid-portion of said normalised inspiratory part as a measure of partial obstruction.
Claim 43
Dependent Claim
216 words
Apparatus for controlling the administration of CPAP treatment to the airway of a patient comprising means controllable to supply breathable air to the patient's airway continually at a selectable pressure elevated above atmospheric pressure; controlling means for commencing or increasing CPAP treatment pressure if: (a) an apnea is occurring, determined by: measuring respiratory air flow from the patient as a function of time; and determining the variance of said measured air flow as an indication of an apnea occurring; or (b) there is partial obstruction of the airway, determined by: measuring respiratory air flow from the patient; detecting the inspiratory part of said air flow; normalising said inspiratory part; and determining an index value of a mid-portion of said normalised inspiratory part as a measure of partial obstruction; or (c) there is patency of the airway, determined by: (i) applying an oscillatory pressure waveform of known frequency to the patient's airway; measuring respiratory air flow from the patient; and determining that the airway is patent if there is a component of said air flow at said known frequency induced by said oscillatory pressure waveform; or (ii) measuring respiratory air flow from the patient; and analysing said measured air flow to detect the presence of cardiogenic air flow, and if so then the airway is declared patent.
Claim 44
Dependent Claim
216 words
Apparatus for controlling the administration of CPAP treatment to the airway of a patient comprising means controllable to supply breathable air to the patient's airway continually at a selectable pressure elevated above atmospheric pressure; controlling means for commencing or increasing CPAP treatment pressure if: (a) an apnea is occurring, determined by: measuring respiratory air flow from the patient as a function of time; and determining the variance of said measured air flow as an indication of an apnea occurring; or (b) there is partial obstruction of the airway, determined by: measuring respiratory air flow from the patient; detecting the inspiratory part of said air flow; normalising said inspiratory part; and determining an index value of a mid-portion of said normalised inspiratory part as a measure of partial obstruction; or (c) there is patency of the airway, determined by: (i) applying an oscillatory pressure waveform of known frequency to the patient's airway; measuring respiratory air flow from the patient; and determining that the airway is patent if there is a component of said air flow at said known frequency induced by said oscillatory pressure waveform; or (ii) measuring respiratory air flow from the patient; and analysing said measured air flow to detect the presence of cardiogenic air flow, and if so then the airway is declared patent.
Claim 45
Independent Claim
176 words
An apparatus for the administration of CPAP treatment, said apparatus comprising: a mask to be worn by a patient to provide breathable gas at a pressure elevated above atmospheric pressure continuously to a patient's airway; a conduit coupled to said mask; a controllable turbine coupled to said conduit to supply at its outlet said pressurized breathable gas to said mask via said conduit; control means to control turbine outlet pressure in response to a control signal; air flow measurement means for measuring patient respiratory air flow; and data processing means coupled to said measurement means to receive said measured air flow and for generating said control signal, and having data processing elements including: a detection element for detecting the inspiratory parts of said air flow; and a computational means for determining an index value of a mid-portion of at least one said inspiratory part as a measure of partial obstruction of said patient airway, and if partial obstruction is detected, for causing said control signal to commence or increase said turbine outlet pressure of breathable gas.
Claim 46
Independent Claim
176 words
An apparatus for the administration of CPAP treatment, said apparatus comprising: a mask to be worn by a patient to provide breathable gas at a pressure elevated above atmospheric pressure continuously to a patient's airway; a conduit coupled to said mask; a controllable turbine coupled to said conduit to supply at its outlet said pressurized breathable gas to said mask via said conduit; control means to control turbine outlet pressure in response to a control signal; air flow measurement means for measuring patient respiratory air flow; and data processing means coupled to said measurement means to receive said measured air flow and for generating said control signal, and having data processing elements including: a detection element for detecting the inspiratory parts of said air flow; and a computational means for determining an index value of a mid-portion of at least one said inspiratory part as a measure of partial obstruction of said patient airway, and if partial obstruction is detected, for causing said control signal to commence or increase said turbine outlet pressure of breathable gas.
Claim 47
Independent Claim
137 words
An apparatus for detecting partial obstruction of the airway of a patient, the apparatus comprising: air flow measurement means for measuring patient respiratory air flow; data processing means coupled to said measurement means to receive said measured air flow, and having a plurality of processing elements including; a detection element for detecting the inspiratory parts of said air flow; and a computational means for determining an index value of a mid-portion of at least one said inspiratory part as a measure of partial obstruction; a means for applying an oscillatory pressure waveform of known frequency to said airway; and wherein said data processing means further includes a spectral analysis element for determining if there is a component of said air flow at said known frequency as induced by said oscillatory pressure waveform as being indicative of potency.
Claim 48
Independent Claim
137 words
An apparatus for detecting partial obstruction of the airway of a patient, the apparatus comprising: air flow measurement means for measuring patient respiratory air flow; data processing means coupled to said measurement means to receive said measured air flow, and having a plurality of processing elements including; a detection element for detecting the inspiratory parts of said air flow; and a computational means for determining an index value of a mid-portion of at least one said inspiratory part as a measure of partial obstruction; a means for applying an oscillatory pressure waveform of known frequency to said airway; and wherein said data processing means further includes a spectral analysis element for determining if there is a component of said air flow at said known frequency as induced by said oscillatory pressure waveform as being indicative of potency.
Claim 49
Independent Claim
157 words
An apparatus for detecting partial obstruction of the airway of a patient, the apparatus comprising: air flow measurement means for measuring patient respiratory air flow; data processing means coupled to said measurement means to receive said measured air flow, and having a plurality of processing elements including; a detection element for detecting the inspiratory parts of said air flow; and a computational means for determining an index value of a mid-portion of at least one said inspiratory part as a measure of partial obstruction; a means far applying an oscillatory pressure waveform of known frequency and magnitude to said airway; and wherein said data processing means further includes a measuring element for determining the magnitude of a component of said air flaw at said known frequency induced by said oscillatory pressure waveform; and further wherein said computational element determines the degree of patency as a ratio of said measured component magnitude and said oscillatory pressure waveform magnitude.
Claim 50
Independent Claim
157 words
An apparatus for detecting partial obstruction of the airway of a patient, the apparatus comprising: air flow measurement means for measuring patient respiratory air flow; data processing means coupled to said measurement means to receive said measured air flow, and having a plurality of processing elements including; a detection element for detecting the inspiratory parts of said air flow; and a computational means for determining an index value of a mid-portion of at least one said inspiratory part as a measure of partial obstruction; a means far applying an oscillatory pressure waveform of known frequency and magnitude to said airway; and wherein said data processing means further includes a measuring element for determining the magnitude of a component of said air flaw at said known frequency induced by said oscillatory pressure waveform; and further wherein said computational element determines the degree of patency as a ratio of said measured component magnitude and said oscillatory pressure waveform magnitude.
Claim 51
Independent Claim
185 words
An apparatus for detecting partial obstruction of the airway of a patient, the apparatus comprising: air flow measurement means for measuring patient respiratory air flow; data processing means coupled to said measurement means to receive said measured air flow, and having a plurality of processing elements including: a detection element for detecting the inspiratory parts of said air flow; and a computational means for determining an index value of a mid-portion of at least one said inspiratory part as a measure of partial obstruction, said computational means further determines the variance of said measured air flow, and said data processing means further includes a comparing element to compare said variance with a predetermined threshold value, and if said variance falls below said threshold value it is determined that an apnea is occurring, a means for applying an oscillatory pressure waveform of known frequency to said airway; and wherein said data processing means further includes a spectral analysis element for determining if there is a component of said air flaw at said known frequency as induced by said oscillatory pressure waveform as being indicative of potency.
Claim 52
Independent Claim
185 words
An apparatus for detecting partial obstruction of the airway of a patient, the apparatus comprising: air flow measurement means for measuring patient respiratory air flow; data processing means coupled to said measurement means to receive said measured air flow, and having a plurality of processing elements including: a detection element for detecting the inspiratory parts of said air flow; and a computational means for determining an index value of a mid-portion of at least one said inspiratory part as a measure of partial obstruction, said computational means further determines the variance of said measured air flow, and said data processing means further includes a comparing element to compare said variance with a predetermined threshold value, and if said variance falls below said threshold value it is determined that an apnea is occurring, a means for applying an oscillatory pressure waveform of known frequency to said airway; and wherein said data processing means further includes a spectral analysis element for determining if there is a component of said air flaw at said known frequency as induced by said oscillatory pressure waveform as being indicative of potency.
Claim 53
Independent Claim
204 words
An apparatus for detecting partial obstruction of an airway of a patient, the apparatus comprising: air flow measurement means for measuring patient respiratory air flow; data processing means coupled to said measurement means to receive said measured air flow, and having a plurality of processing elements including: a detection element for detecting the inspiratory parts of said air flow; and a computational means for determining an index value of a mid-portion of at least one said inspiratory part as a measure of partial obstruction, said computational means further determines the variance of said measured air flow, and said data processing means further includes a comparing element to compare said variance with a predetermined threshold value, and if said variance falls below said threshold value it is determined that an apnea is occurring; a means for applying an oscillatory pressure waveform of known frequency and magnitude to said airway and wherein said data processing means further includes a measuring element for determining magnitude of a component of said air flow at said known frequency induced by said oscillatory pressure waveform; and further wherein said computational element determines the degree of patency as a ratio of said measured component magnitude and said oscillatory pressure waveform magnitude.
Claim 54
Independent Claim
204 words
An apparatus for detecting partial obstruction of an airway of a patient, the apparatus comprising: air flow measurement means for measuring patient respiratory air flow; data processing means coupled to said measurement means to receive said measured air flow, and having a plurality of processing elements including: a detection element for detecting the inspiratory parts of said air flow; and a computational means for determining an index value of a mid-portion of at least one said inspiratory part as a measure of partial obstruction, said computational means further determines the variance of said measured air flow, and said data processing means further includes a comparing element to compare said variance with a predetermined threshold value, and if said variance falls below said threshold value it is determined that an apnea is occurring; a means for applying an oscillatory pressure waveform of known frequency and magnitude to said airway and wherein said data processing means further includes a measuring element for determining magnitude of a component of said air flow at said known frequency induced by said oscillatory pressure waveform; and further wherein said computational element determines the degree of patency as a ratio of said measured component magnitude and said oscillatory pressure waveform magnitude.
Claim 55
Dependent Claim
16 words
The method of claim 17, whereby said index value is averaged over two or more breaths.
Claim 56
Dependent Claim
34 words
A method as claimed in claim 29, comprising the further step of detecting the patient's cardia rate, and whereby the analyzing step includes detecting a component of said air flow at the cardiac rate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-01-05 | 2001-07-07 | 2002-01-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-01-05 | 2005-07-07 | 2006-01-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-01-05 | 2009-07-07 | 2010-01-06 | $7700.00 | Window Closed / Lapsed |