US5702432A — Intracorporeal light treatment of blood

Claim 1

Independent Claim 212 words

Apparatus for administering intracorporeal photopheresis to blood flowing in a patient's body to destroy or affect an undesirable component in the blood, where the undesirable component has absorbed a photoreactive agent having a characteristic light absorption waveband, said apparatus comprising: (a) an implantable housing adapted to be transcutaneously placed at a site within a patient's body, said implantable housing comprising a biocompatible material and having an inlet port and an outlet port adapted to couple to a patient's circulatory system to convey the blood circulated thereby into and out of the housing; (b) a light source coupled to the housing, said light source emitting light within a waveband substantially equal to the absorption waveband of the photoreactive agent; (c) a power source for supplying an electrical current to energize said light source; and (d) a fluid path disposed within the housing adjacent to the light source and in fluid communication with said inlet port and said outlet port, at least a portion of said fluid path being optically transparent, so that blood circulating through the fluid path is irradiated with the light emitted by said light source to effect the light treatment, said blood circulating through the fluid path sufficiently fast to avoid heat build up that might otherwise harm the blood.

Claim 2

Dependent Claim 212 words

Apparatus for administering intracorporeal photopheresis to blood flowing in a patient's body to destroy or affect an undesirable component in the blood, where the undesirable component has absorbed a photoreactive agent having a characteristic light absorption waveband, said apparatus comprising: (a) an implantable housing adapted to be transcutaneously placed at a site within a patient's body, said implantable housing comprising a biocompatible material and having an inlet port and an outlet port adapted to couple to a patient's circulatory system to convey the blood circulated thereby into and out of the housing; (b) a light source coupled to the housing, said light source emitting light within a waveband substantially equal to the absorption waveband of the photoreactive agent; (c) a power source for supplying an electrical current to energize said light source; and (d) a fluid path disposed within the housing adjacent to the light source and in fluid communication with said inlet port and said outlet port, at least a portion of said fluid path being optically transparent, so that blood circulating through the fluid path is irradiated with the light emitted by said light source to effect the light treatment, said blood circulating through the fluid path sufficiently fast to avoid heat build up that might otherwise harm the blood.

Claim 3

Dependent Claim 14 words

The apparatus of claim 1, wherein the fluid path comprises a serpentine shaped passage.

Claim 4

Dependent Claim 14 words

The apparatus of claim 1, wherein the fluid path comprises a helically coiled passage.

Claim 5

Dependent Claim 14 words

The apparatus of claim 1, wherein the fluid path is a substantially planar coil.

Claim 6

Dependent Claim 42 words

The apparatus of claim 1, wherein the fluid path comprises a plurality of parallel passages extending between two headers, one of said two headers being coupled to the inlet port and another of the two headers being coupled to the outlet port.

Claim 7

Dependent Claim 26 words

The apparatus of claim 1, wherein the light source comprises one of a first generally planar array of spaced-apart light emitting devices and a luminescent panel.

Claim 8

Dependent Claim 50 words

The apparatus of claim 6, wherein the light source further comprises a second generally planar array of spaced-apart light emitting devices, said first and said second arrays being disposed at opposite sides of the fluid path with the light emitting devices being directed to emit light toward the fluid path.

Claim 9

Dependent Claim 18 words

The apparatus of claim 6, wherein the light emitting devices are mounted on a substantially light reflecting surface.

Claim 10

Dependent Claim 32 words

The apparatus of claim 1, wherein the light source comprises a bar that includes a plurality of light emitting devices that are spaced apart generally along a longitudinal axis of the bar.

Claim 11

Dependent Claim 21 words

The apparatus of claim 1, wherein the light source comprises a plurality of optical fibers coupled to a light emitting device.

Claim 12

Dependent Claim 14 words

The apparatus of claim 1, wherein the power source is integral with the housing.

Claim 13

Dependent Claim 33 words

The apparatus of claim 1, wherein the power source is disposed within an enclosure comprising a biocompatible material and is thus adapted to be implanted within the patient's body, separate from the housing.

Claim 14

Dependent Claim 24 words

The apparatus of claim 1, wherein the housing includes a tab usable for securing the housing at a desired location within the patient's body.

Claim 15

Dependent Claim 15 words

The apparatus of claim 1, wherein the housing has a substantially light reflective inner surface.

Claim 16

Dependent Claim 17 words

The apparatus of claim 1, wherein the inlet port and the outlet port comprise vascular graft tubing.

Claim 17

Dependent Claim 25 words

The apparatus of claim 1, wherein an inner surface of the fluid path is coated with a medicinal substance that resists formation of blood clots.

Claim 18

Independent Claim 192 words

A method for treating blood flowing in a patient's body to destroy an undesirable component in the patient's blood, comprising the steps of: (a) administering a photoreactive agent to the patient, said photoreactive agent being absorbed by the undesirable component in the blood and having a characteristic light absorption waveband; (b) providing an implantable photoreactor having a light source for use in exposing the blood within the patient's body to light having a waveband substantially equal to the characteristic light absorption waveband of the photoreactive agent; (c) creating a surgical incision within the patient's body to expose a site for implantation of the photoreactor; (d) coupling the implantable reactor into the patient's circulatory system so that the patient's blood circulates through the implantable reactor; (e) closing the surgical incision over the implantable reactor, leaving it at the site internally within the patient's body; and (f) exposing the blood circulating through the photoreactor to the light from the light source within the photoreactor in order to destroy or adversely affect the undesirable component, said blood circulating through the fluid path sufficiently fast to avoid heat build up that might otherwise harm the blood.

Claim 19

Independent Claim 192 words

A method for treating blood flowing in a patient's body to destroy an undesirable component in the patient's blood, comprising the steps of: (a) administering a photoreactive agent to the patient, said photoreactive agent being absorbed by the undesirable component in the blood and having a characteristic light absorption waveband; (b) providing an implantable photoreactor having a light source for use in exposing the blood within the patient's body to light having a waveband substantially equal to the characteristic light absorption waveband of the photoreactive agent; (c) creating a surgical incision within the patient's body to expose a site for implantation of the photoreactor; (d) coupling the implantable reactor into the patient's circulatory system so that the patient's blood circulates through the implantable reactor; (e) closing the surgical incision over the implantable reactor, leaving it at the site internally within the patient's body; and (f) exposing the blood circulating through the photoreactor to the light from the light source within the photoreactor in order to destroy or adversely affect the undesirable component, said blood circulating through the fluid path sufficiently fast to avoid heat build up that might otherwise harm the blood.

Claim 20

Dependent Claim 40 words

The method of claim 17, wherein the step of creating a surgical incision further includes the step of removing a section of a rib to gain access to the patient's circulatory system and to provide the site for the photoreactor.

Claim 21

Dependent Claim 49 words

The method of claim 17, wherein the step of coupling the implantable reactor into the patient's circulatory system includes the step of transecting a blood vessel to couple ends of the blood vessel to the photoreactor, so that the blood flowing through the blood vessel flows through the photoreactor.

Claim 22

Dependent Claim 55 words

The method of claim 17, wherein the step of exposing comprises the step of circulating the blood through the photoreactor through one of serpentine tubing, planar coiled tubing, tubing extending between two headers, and helically coiled tubing, thereby providing a greater exposure of the blood to the light as the blood flows through the photoreactor.

Claim 23

Dependent Claim 68 words

The method of claim 17, wherein the housing includes vascular graft tubing at an inlet port and an outlet port, said step of coupling comprising the step of suturing the vascular graft tubing into a blood vessel within the patient's body, said vascular graft tubing conveying the blood flowing through the blood vessel into and out from the photoreactor via the inlet port and the outlet port, respectively.

Claim 24

Dependent Claim 26 words

The method of claim 17, further comprising the step of attaching the photoreactor to tissue in the patient's body to secure the photoreactor at said site.

Claim 25

Dependent Claim 29 words

The method of claim 17, wherein the blood circulating through the photoreactor is exposed to light from a plurality of light emitting devices that are coupled to the photoreactor.

Claim 26

Dependent Claim 19 words

The method of claim 17, wherein the blood circulating through the reactor is exposed to light from opposite sides.

Claim 27

Dependent Claim 25 words

The method of claim 17, further comprising the step of infusing an anti-clotting medicinal substance into the blood as the blood circulates through the photoreactor.

Claim 28

Dependent Claim 35 words

The method of claim 17, further comprising the step of coupling power to a power supply implanted within the patient's body from an external source, said power supply being used to electrically energize the photoreactor.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	2000-12-29	2001-06-30	2001-12-30	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2004-12-29	2005-06-30	2005-12-30	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2008-12-29	2009-06-30	2009-12-30	$7700.00	Window Closed / Lapsed

Intracorporeal light treatment of blood

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