US5699795A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Optical probe for the detection of cervical neoplasia using fluorescence spectroscopy and apparatus incorporating same
Assignee: The University of Texas System
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Filing: 1995-03-31
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Granted: 1997-12-23
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Expires: 2015-03-31
Abstract
Abstract A probe, and an apparatus incorporating the probe, for detecting tissue abnormality, particularly precancerous cervical tissue, through fluorescence spectroscopy are disclosed. In vivo fluorescence excitation and detection can be accomplished easily and accurately using a probe whose tip conforms to the surface of the cervix. In addition, a higher number of fiber pairs provides more information and, therefore, more accurate diagnosis.
Inventors
- 👤 Rebecca Richards-Kortum
- 👤 Costas Pitris
- 👤 Michele Follen Mitchell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 16:22
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/0059; A61B5/0082; A61B5/0084; A61B5/0071; A61B5/43; A61B5/4306; A61B5/4318; A61B5/4331; A61B5/0075
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
101 words
An optical probe for cervical examination comprising: (a) a probe casing having an elongate portion and at least two openings, wherein one of said openings is disposed at a distal tip of said elongate portion of said casing; (b) a plurality of optical fiber pairs, each of said pairs comprising an excitation fiber and a collection fiber, said optical fibers entering said casing at the non-tip opening and traversing said casing to said tip opening; and (c) a substantially optically transparent window with a surface structured to conform to the surface of the human cervix, said window covering said tip opening.
Claim 2
Dependent Claim
101 words
An optical probe for cervical examination comprising: (a) a probe casing having an elongate portion and at least two openings, wherein one of said openings is disposed at a distal tip of said elongate portion of said casing; (b) a plurality of optical fiber pairs, each of said pairs comprising an excitation fiber and a collection fiber, said optical fibers entering said casing at the non-tip opening and traversing said casing to said tip opening; and (c) a substantially optically transparent window with a surface structured to conform to the surface of the human cervix, said window covering said tip opening.
Claim 3
Dependent Claim
17 words
The probe according to claim 1, wherein at least a portion of said window is substantially conical.
Claim 4
Dependent Claim
15 words
The probe according to claim 2, wherein said window surface also comprises a non-conical portion.
Claim 5
Dependent Claim
41 words
The probe according to claim 3, wherein said tip is about 40 mm in width, having a minimum thickness of about 6.6 mm and a maximum thickness of about 10 mm, and said conical portion is about 10 mm in width.
Claim 6
Dependent Claim
14 words
The probe according to claim 5, wherein said probe casing is a hollow tube.
Claim 7
Dependent Claim
15 words
The probe according to claim 5, wherein said probe casing is comprised of carbonized epoxy.
Claim 8
Dependent Claim
14 words
The probe according to claim 5, wherein said probe casing is comprised of aluminum.
Claim 9
Dependent Claim
16 words
The probe according to claim 1, wherein said probe casing is further encased in heat-shrink tubing.
Claim 10
Dependent Claim
17 words
The probe according to claim 1, wherein individual fibers are comprised of a core and a cladding.
Claim 11
Dependent Claim
13 words
The probe according to claim 9, wherein said plurality is 31 or greater.
Claim 12
Dependent Claim
15 words
The probe according to claim 10, wherein said plurality is greater than 357 or greater.
Claim 13
Dependent Claim
13 words
The probe according to claim 1, wherein said window is comprised of quartz.
Claim 14
Dependent Claim
14 words
The probe according to claim 1, wherein said window is comprised of BK7 glass.
Claim 15
Dependent Claim
31 words
The probe according to claim 1, wherein said tip is about 10 mm in width, having a minimum thickness of about 4 mm and a maximum thickness of about 7.6 mm.
Claim 16
Dependent Claim
14 words
The probe according to claim 1, wherein said tip further comprises a perforated plate.
Claim 17
Dependent Claim
24 words
The probe according to claim 15, wherein said plate is aluminum and said perforations are 500 μm in diameter and spaced every 2 mm.
Claim 18
Dependent Claim
37 words
The probe according to claim 1, wherein each of said fiber pairs are disposed in the center of glass tubes, said glass tubes having an inner diameter of 500 μm and an outer diameter of 2 mm.
Claim 19
Dependent Claim
47 words
An apparatus for measuring tissue fluorescence comprising (a) a probe according to claim 1; (b) an electromagnetic radiation generator coupled to each excitation fiber; (c) a fluorescence spectrum detector coupled to each collection fiber; and (d) means coupled to the fluorescence spectrum detector for analyzing spectral information.
Claim 20
Dependent Claim
37 words
The apparatus of claim 18, wherein said fiber pairs of said probe are connected to said fluorescent spectrum detector by a coupling means, said fiber pairs in said coupling means being arranged in a substantially linear fashion.
Claim 21
Dependent Claim
98 words
A probe for the optical examination of a generally annular region of the human cervix comprising: (a) a generally elongated probe body having an optically transparent distal region generally in conformity with the generally annular cervix region; (b) an excitation fiber traversing at least a portion of the probe body to the distal region having an optical axis traverse to a portion of the distal region; and (c) a plurality of collection fibers traversing at least a portion of the probe body to the distal region and having respective optical axes transverse to portions of the distal region.
Claim 22
Dependent Claim
98 words
A probe for the optical examination of a generally annular region of the human cervix comprising: (a) a generally elongated probe body having an optically transparent distal region generally in conformity with the generally annular cervix region; (b) an excitation fiber traversing at least a portion of the probe body to the distal region having an optical axis traverse to a portion of the distal region; and (c) a plurality of collection fibers traversing at least a portion of the probe body to the distal region and having respective optical axes transverse to portions of the distal region.
Claim 23
Dependent Claim
36 words
A probe as in claim 20, wherein the probe body further comprises a housing, the distal region comprising a generally planar section coupled to the housing and a generally conical section extending from the planar section.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-12-22 | 2001-06-23 | 2001-12-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-12-22 | 2005-06-23 | 2005-12-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-12-22 | 2009-06-23 | 2009-12-23 | $7700.00 | Window Closed / Lapsed |