US5688516A
Expired / Lapsed
US
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Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices
Assignee: Baylor College of Medicine
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Filing: 1994-10-03
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Granted: 1997-11-18
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Expires: 2014-10-03
Abstract
Abstract Compositions and methods of employing compositions in flushing and coating medical devices are disclosed. The compositions include selected combinations of a chelating agent, anticoagulant, or antithrombotic agent, with an non-glycopeptide antimicrobial agent, such as the tetracycline antibiotics. Methods of using these compositions for coating a medical device and for inhibiting catheter infection are also disclosed. Particular combinations of the claimed combinations include minocycline or other non-glycopeptide antimicrobial agent together with EDTA, EGTA, DTPA, TTH, heparin and/or hirudin in a pharmaceutically acceptable diluent.
Inventors
- 👤 Isaam Raad
- 👤 Robert Sherertz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 13:55
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/14; A61L29/16; A61L29/08; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/42; A61L2300/45; A61L2300/60; A61L2300/606; A61L2300/80; A61L2300/802; A61M; A61M25/00; A61M25/0043; A61M2025/0056
Claims Analysis
Total Claims: 54
Claim 1
Independent Claim
76 words
A composition comprising a non-glycopeptide antimicrobial agent other than vancomycin and a second agent selected from the group consisting of: (a) an anticoagulant, (b) an antithrombotic agent and (c) a chelating agent selected from the group consisting of: EGTA, diethylenetriamine penta acetic acid, DMSA, deferoxamine, dimercaprol, zinc citrate, a combination of bismuth and citrate, penicillamine, succimer and Etidronate, wherein the agents are included in a therapeutically effective amount between about 0.001 mg/ml and about 1000 mg/ml.
Claim 2
Dependent Claim
76 words
A composition comprising a non-glycopeptide antimicrobial agent other than vancomycin and a second agent selected from the group consisting of: (a) an anticoagulant, (b) an antithrombotic agent and (c) a chelating agent selected from the group consisting of: EGTA, diethylenetriamine penta acetic acid, DMSA, deferoxamine, dimercaprol, zinc citrate, a combination of bismuth and citrate, penicillamine, succimer and Etidronate, wherein the agents are included in a therapeutically effective amount between about 0.001 mg/ml and about 1000 mg/ml.
Claim 3
Dependent Claim
14 words
The composition of claim 1, comprising a non-glycopeptide antimicrobial agent and a chelating agent.
Claim 4
Dependent Claim
11 words
The composition of claim 2, wherein the chelating agent is EGTA.
Claim 5
Dependent Claim
22 words
The composition of claim 1, comprising a chelating agent selected from the group consisting of diethylenetriamine penta acetic acid, Etidronate and EGTA.
Claim 6
Dependent Claim
13 words
The composition of claim 1, comprising a non-glycopeptide antimicrobial agent and an anticoagulant.
Claim 7
Dependent Claim
10 words
The composition of claim 5, wherein the anticoagulant is heparin.
Claim 8
Dependent Claim
10 words
The composition of claim 5, wherein the anticoagulant is hirudin.
Claim 9
Dependent Claim
41 words
The composition of claim 1, wherein the non-glycopeptide antimicrobial agent selected from the group consisting of aminoglycoside, amphotericin B, ampicillin, carbenicillin, cefazolin, cephalosporin, chloramphenicol, clindamycin, erythromycin, gentamicin, griseofulvin, kanamycin, methicillin, nafcillin, novobiocin, penicillin, polymyxin, rifampin, streptomycin, sulfamethoxazole, sulfonamide, tetracycline, and trimethoprim.
Claim 10
Dependent Claim
14 words
The composition of claim 8, wherein the non-glycopeptide antimicrobial agent is a tetracycline antibiotic.
Claim 11
Dependent Claim
23 words
The composition of claim 9, wherein the tetracycline antibiotic is selected from the group consisting of chlortetracycline, oxytetracycline, demeclocycline, methacycline, minocycline and doxycycline.
Claim 12
Dependent Claim
20 words
The composition of claim 10, wherein the tetracycline antibiotic is selected from the group consisting of minocycline, doxycline and oxytetracycline.
Claim 13
Dependent Claim
25 words
The composition of claim 8, wherein the non-glycopeptide antimicrobial agent is selected from the group consisting of amphotericin B, chloramphenicol, gentamicin, griseofulvin, rifampin and sulfamethoxazole.
Claim 14
Dependent Claim
12 words
The composition of claim 1, further comprising a pharmacologically acceptable carrier solution.
Claim 15
Dependent Claim
25 words
The composition of claim 1, wherein the antimicrobial agent and the second agent is included in amounts ranging from about 1 to about 200 mg/ml.
Claim 16
Dependent Claim
25 words
The composition of claim 14, wherein the antimicrobial agent and the second agent is included in amounts ranging from about 2 to about 100 mg/ml.
Claim 17
Dependent Claim
21 words
The composition of claim 15, wherein the second agent is included in an amount from about 20 to about 60 mg/ml.
Claim 18
Dependent Claim
21 words
The composition of claim 16, wherein the antimicrobial agent is included in amounts ranging from about 2 to about 9 mg/ml.
Claim 19
Dependent Claim
20 words
The composition of claim 1, wherein the antimicrobial agent comprises a combination of a tetracycline antibiotic and a rifamycin antibiotic.
Claim 20
Dependent Claim
20 words
The composition of claim 1, wherein the antimicrobial agent is a tetracycline antibiotic and the second agent is a chelator.
Claim 21
Dependent Claim
21 words
The composition of claim 19, wherein the chelator is selected from the group consisting of diethylenetriamine pentaacetic acid, Etidronate and EGTA.
Claim 22
Dependent Claim
10 words
The composition of claim 20, wherein the chelator is EGTA.
Claim 23
Dependent Claim
15 words
The composition of claim 19, further comprising a therapeutically effective amount of a rifamycin antibiotic.
Claim 24
Dependent Claim
16 words
The composition of claim 1, wherein said chelating agent chelates Ca, Mg, Mn, Fe or Zn.
Claim 25
Dependent Claim
52 words
A medical device coated with a composition comprising a non-glycopeptide antimicrobial agent and a second agent selected from the group consisting of: (a) an anticoagulant, (b) an antithrombotic agent and (c) a chelating agent; wherein the agents are included in a therapeutically effective amount between about 0.001 mg/ml and about 1000 mg/ml.
Claim 26
Dependent Claim
52 words
A medical device coated with a composition comprising a non-glycopeptide antimicrobial agent and a second agent selected from the group consisting of: (a) an anticoagulant, (b) an antithrombotic agent and (c) a chelating agent; wherein the agents are included in a therapeutically effective amount between about 0.001 mg/ml and about 1000 mg/ml.
Claim 27
Dependent Claim
29 words
The medical device of claim 24, wherein the composition comprises a chelating agent selected from the group consisting of EDTA, triethylene tetramine dihydrochloride, diethylenetriamine pentaacetic acid, Etidronate and EGTA.
Claim 28
Dependent Claim
17 words
The medical device of claim 24, wherein the composition comprises a non-glycopeptide antimicrobial agent and an anticoagulant.
Claim 29
Dependent Claim
11 words
The medical device of claim 26, wherein the anticoagulant is heparin.
Claim 30
Dependent Claim
11 words
The medical device of claim 26, wherein the anticoagulant is hirudin.
Claim 31
Dependent Claim
18 words
The medical device of claim 24, wherein the composition comprises a non-glycopeptide antimicrobial agent and a chelating agent.
Claim 32
Dependent Claim
12 words
The medical device of claim 29, wherein the chelating agent is EGTA.
Claim 33
Dependent Claim
15 words
The medical device of claim 30, wherein the non-glycopeptide antimicrobial agent is a tetracycline antibiotic.
Claim 34
Dependent Claim
12 words
The medical device of claim 31, wherein the tetracycline antibiotic is minocycline.
Claim 35
Dependent Claim
54 words
The medical device of claim 32, further defined as selected from the group of devices consisting of a central venous catheter, a peripheral intravenous catheter, an arterial catheter, a Swant-Ganz catheter, a hemodialysis catheter, an umbilical catheter, a percutaneous nontunneled silicone catheter, a cuffed tunneled central venous catheter and a subcutaneous central venous pert.
Claim 36
Dependent Claim
44 words
The medical device of claim 24, wherein the non-glycopeptide antimicrobial agent is selected from the group consisting of aminoglycoside, amphotericin B, ampicillin, carbenicillin, cefazolin, cephalosporin, chloramphenicol, clindamycin, erythromycin, gentamicin, griseofulvin, kanamycin, methicillin, nafcillin, novobiocin, penicillin, polymyxin, rifampin, streptomycin, sulfamethoxazole, sulfonamide, tetracycline, trimethoprim, and vancomycin.
Claim 37
Dependent Claim
15 words
The medical device of claim 34, wherein the non-glycopeptide antimicrobial agent is a tetracycline antibiotic.
Claim 38
Dependent Claim
24 words
The medical device of claim 35, wherein the tetracycline antibiotic is selected from the group consisting of chlortetracycline, oxytetracycline, demeclocycline, methacycline, minocycline and doxycycline.
Claim 39
Dependent Claim
21 words
The medical device of claim 36, wherein the tetracycline antibiotic is selected from the group consisting of minocycline, doxycycline and oxytetracycline.
Claim 40
Dependent Claim
26 words
The medical device of claim 34, wherein the non-glycopeptide antimicrobial agent is selected from the group consisting of amphotericin B, chloramphenicol, gentamicin, griseofulvin, rifampin and sulfamethoxazole.
Claim 41
Dependent Claim
16 words
The device of claim 34, coated with the combination of a tetracycline antibiotic and a chelator.
Claim 42
Dependent Claim
25 words
The device of claim 39, wherein the chelator is selected from the group consisting of EDTA, triethylene tetramine dihydrochloride, diethylenetriamine pentaacetic acid, Etidronate and EGTA.
Claim 43
Dependent Claim
18 words
The device of claim 39, wherein the composition further comprises a therapeutically effective amount of a rifamycin antibiotic.
Claim 44
Dependent Claim
18 words
The device of claim 41, coated with a combination of minocycline, rifampin and a chelator other than EDTA.
Claim 45
Dependent Claim
16 words
The medical device of claim 24, wherein the composition further comprises a pharmacologically acceptable carrier solution.
Claim 46
Dependent Claim
26 words
The medical device of claim 24, wherein the antimicrobial agent and the second agent is included in amounts ranging from about 1 to about 200 mg/ml.
Claim 47
Dependent Claim
26 words
The medical device of claim 44, wherein the antimicrobial agent and the second agent is included in amounts ranging from about 2 to about 100 mg/ml.
Claim 48
Dependent Claim
22 words
The medical device of claim 45, wherein the second agent is included in an amount from about 20 to about 60 mg/ml.
Claim 49
Dependent Claim
22 words
The medical device of claim 46, wherein the antimicrobial agent is included in amounts ranging from about 2 to about 9 mg/ml.
Claim 50
Dependent Claim
21 words
The medical device of claim 24, (wherein the antimicrobial agent comprises a combination of a tetracycline antibiotic and a rifamycin antibiotic.
Claim 51
Dependent Claim
57 words
A medical device prepared by a process comprising exposing the medical device to a composition comprising a non-glycopeptide antimicrobial agent and a second agent selected from the group consisting of a chelating agent, an anticoagulant, and an antithrombotic agent, wherein the agents are included in a therapeutically effective amount between about 0.001 mg/ml and about 1000 mg/ml.
Claim 52
Dependent Claim
57 words
A medical device prepared by a process comprising exposing the medical device to a composition comprising a non-glycopeptide antimicrobial agent and a second agent selected from the group consisting of a chelating agent, an anticoagulant, and an antithrombotic agent, wherein the agents are included in a therapeutically effective amount between about 0.001 mg/ml and about 1000 mg/ml.
Claim 53
Dependent Claim
23 words
The medical device of claim 49, wherein the process comprises treating the device with a surfactant before exposing the device to the composition.
Claim 54
Dependent Claim
24 words
The medical device of claim 50, wherein the surfactant is selected from the group of surfactant consisting of tridodecylmethyl ammonium chloride and benzalkonium chloride.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-11-17 | 2001-05-19 | 2001-11-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-11-17 | 2005-05-19 | 2005-11-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-11-17 | 2009-05-19 | 2009-11-18 | $7700.00 | Window Closed / Lapsed |