US5688489A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Non-receptor mediated imaging agents
Assignee: Bracco Imaging SpA
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Filing: 1995-09-15
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Granted: 1997-11-18
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Expires: 2015-09-15
Abstract
Abstract Detectably labelled non-receptor mediated cell-associating compounds are provided for use in the diagnostic imaging of target sites in a mammal. Cell-associating compounds may be directly labelled, or labelled via a chelating compound to form a conjugate. Such cell-associating compounds are particularly useful to image target sites such as tumour sites and sites of infection.
Inventors
- 👤 Susan H. Peers
- 👤 Anne Goodbody
- 👤 Alfred Pollak
- 👤 John Thornback
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 04:30
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/088; C; C07; C07K; C07K14/00; C07K14/001; C07K14/435; C07K14/46; A61K2123/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
3 words
The compound, dimethyl-G-S-C(Acm)-βA-βA-βA-G-I-G-K-F-L-H-S-A-G-K-F-G-K-A-F-V-G-E-I-M-K-S.
Claim 2
Dependent Claim
3 words
The compound, dimethyl-G-S-C(Acm)-βA-βA-βA-G-I-G-K-F-L-H-S-A-G-K-F-G-K-A-F-V-G-E-I-M-K-S.
Claim 3
Dependent Claim
41 words
A non-receptor mediated cell-associating compound coupled to a detectable label, wherein said compound is selected from the group consisting of magainin peptides, and functionally equivalent analogues thereof, wherein said label is linked to said compound via a chelator comprising dimethylglycine-serine-cysteine (Acm).
Claim 4
Dependent Claim
41 words
A non-receptor mediated cell-associating compound coupled to a detectable label, wherein said compound is selected from the group consisting of magainin peptides, and functionally equivalent analogues thereof, wherein said label is linked to said compound via a chelator comprising dimethylglycine-serine-cysteine (Acm).
Claim 5
Dependent Claim
38 words
A compound as defined in claim 2, wherein said chelator is linked to said compound via a linker, wherein said linker is selected from the group consisting of glycine-asparagine-glycine, and a linker consisting of from 1-5 β-alanine residues.
Claim 6
Dependent Claim
68 words
A non-receptor mediated cell-associating compound coupled to a detectable label, wherein said compound is selected from the group consisting of magainin peptides, and functionally equivalent analogs thereof, wherein said label is linked to said compound via a chelator, wherein said chelator is linked to said compound via a linker, and said linker is selected from the group consisting of glycine-asparagine-glycine, and a linker consisting of from 1-5β-alanine residues.
Claim 7
Dependent Claim
68 words
A non-receptor mediated cell-associating compound coupled to a detectable label, wherein said compound is selected from the group consisting of magainin peptides, and functionally equivalent analogs thereof, wherein said label is linked to said compound via a chelator, wherein said chelator is linked to said compound via a linker, and said linker is selected from the group consisting of glycine-asparagine-glycine, and a linker consisting of from 1-5β-alanine residues.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-11-17 | 2001-05-19 | 2001-11-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-11-17 | 2005-05-19 | 2005-11-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-11-17 | 2009-05-19 | 2009-11-18 | $7700.00 | Window Closed / Lapsed |