Patent US5683667A successfully refreshed from Google Patents.
US5683667A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Reactive tricalcium phosphate compositions
Assignee: KNC NOR Acquisition Sub Inc
•
Filing: 1995-12-11
•
Granted: 1997-11-04
•
Expires: 2015-12-11
Abstract
Abstract Methods for producing a room temperature stable, phase pure alpha -C3P product, and compositions derived therefrom, are provided. In the subject method, a tricalcium phosphate source is heated to a temperature sufficient to convert substantially all of said tricalcium phosphate source to a substantially phase pure alpha -C3P product. The temperature of the resultant product is rapidly cooled to a temperature below about 700 DEG C., resulting in a room temperature stable, reactive alpha -C3P product. The resultant alpha -C3P product may be milled to provide an alpha -C3P composition which may find use in the preparation of calcium phosphate cements.
Inventors
- 👤 Mark Fulmer
- 👤 Brent R. Constantz
- 👤 Ira C. Ison
- 👤 Bryan M. Barr
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 23:28
CPC Classifications
C; C01; C01B; C01B25/00; C01B25/16; C01B25/26; C01B25/32; A; A61; A61L; A61L24/00; A61L24/02; A61L27/00; A61L27/02; A61L27/12; C01B25/321; C04; C04B; C04B12/00; C04B12/02; C04B12/025; C04B28/00; C04B28/34; C04B28/344; C04B28/346; A61F; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293; A61L2430/00; A61L2430/38; C04B2111/00; C04B2111/00474; C04B2111/00836
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
148 words
A method for producing a phase pure reactive α-C 3 P composition, said method comprising: heating a room temperature stable tricalcium phosphate source to a first temperature sufficient to cause a substantially uniform transition to phase pure α-C 3 P; rapidly cooling said phase pure α-C 3 P to a second temperature below about 700° C. in less than about 10 min resulting in a room temperature stable, substantially phase pure α-C 3 P product; and milling said room temperature stable, substantially phase pure α-C 3 P product for a period of time ranging from 10 min to 2 hr to produce a composition having a surface area ranging from 2.5 to 3.5 m 2 /g and having a particle size distribution which is graphically represented as a curve having a broad peak and a leading shoulder; whereby said phase pure reactive α-C 3 P composition is produced.
Claim 2
Independent Claim
148 words
A method for producing a phase pure reactive α-C 3 P composition, said method comprising: heating a room temperature stable tricalcium phosphate source to a first temperature sufficient to cause a substantially uniform transition to phase pure α-C 3 P; rapidly cooling said phase pure α-C 3 P to a second temperature below about 700° C. in less than about 10 min resulting in a room temperature stable, substantially phase pure α-C 3 P product; and milling said room temperature stable, substantially phase pure α-C 3 P product for a period of time ranging from 10 min to 2 hr to produce a composition having a surface area ranging from 2.5 to 3.5 m 2 /g and having a particle size distribution which is graphically represented as a curve having a broad peak and a leading shoulder; whereby said phase pure reactive α-C 3 P composition is produced.
Claim 3
Dependent Claim
13 words
The method according to claim 1, wherein said milling is by attritor milling.
Claim 4
Dependent Claim
17 words
A phase pure reactive α-C 3 P composition produced in accordance with the method of claim 1.
Claim 5
Independent Claim
131 words
A method for producing a phase pure reactive α-C 3 P composition comprising: heating a room temperature stable tricalcium phosphate source to a first temperature sufficient to cause a substantially uniform transition to phase pure α-C 3 P; rapidly cooling said phase pure α-C 3 P to a second temperature below 700° C. in less than 10 min resulting in a room temperature stable, substantially phase pure α-C 3 P; and attritor milling said room temperature stable, substantially phase pure α-C 3 P for a period of time ranging from 0.5 to 2.0 hr to produce a composition having a surface area ranging from 2.5 to 3.5 m 2 /g and having a particle size distribution which is graphically represented as a curve having a broad peak and a leading shoulder.
Claim 6
Independent Claim
131 words
A method for producing a phase pure reactive α-C 3 P composition comprising: heating a room temperature stable tricalcium phosphate source to a first temperature sufficient to cause a substantially uniform transition to phase pure α-C 3 P; rapidly cooling said phase pure α-C 3 P to a second temperature below 700° C. in less than 10 min resulting in a room temperature stable, substantially phase pure α-C 3 P; and attritor milling said room temperature stable, substantially phase pure α-C 3 P for a period of time ranging from 0.5 to 2.0 hr to produce a composition having a surface area ranging from 2.5 to 3.5 m 2 /g and having a particle size distribution which is graphically represented as a curve having a broad peak and a leading shoulder.
Claim 7
Dependent Claim
15 words
A reactive α-C 3 P composition produced in accordance with the method of claim 4.
Claim 8
Dependent Claim
89 words
A reactive phase pure α-C 3 P composition comprising particles of room temperature stable, substantially phase pure α-C 3 P ranging in size from 3 to 5 μm, wherein said composition has a surface area ranging from 2.5 to 3.5 m 2 /gm and a particle size distribution which is graphically represented as a curve having a broad peak and a leading shoulder, wherein said leading shoulder is displaced from said broad peak by between about 2 and 4 μm and said broad peak occurs at about 5 μm.
Claim 9
Dependent Claim
89 words
A reactive phase pure α-C 3 P composition comprising particles of room temperature stable, substantially phase pure α-C 3 P ranging in size from 3 to 5 μm, wherein said composition has a surface area ranging from 2.5 to 3.5 m 2 /gm and a particle size distribution which is graphically represented as a curve having a broad peak and a leading shoulder, wherein said leading shoulder is displaced from said broad peak by between about 2 and 4 μm and said broad peak occurs at about 5 μm.
Claim 10
Dependent Claim
24 words
The reactive α-C 3 P composition according to claim 6, wherein said composition has an XRD pattern which is the same as FIG. 3d.
Claim 11
Dependent Claim
18 words
The reactive α-C 3 P composition according to claim 7, wherein said composition is substantially free of impurities.
Claim 12
Dependent Claim
55 words
A reactive phase pure α-C 3 P composition comprising: particles of room temperature stable, substantially phase pure α-C 3 P, wherein the mean particle size of said particles is about 4 μm, and said composition has a surface area of about 3 m 2 /gm and a particle size distribution as represented in FIG. 4a.
Claim 13
Dependent Claim
55 words
A reactive phase pure α-C 3 P composition comprising: particles of room temperature stable, substantially phase pure α-C 3 P, wherein the mean particle size of said particles is about 4 μm, and said composition has a surface area of about 3 m 2 /gm and a particle size distribution as represented in FIG. 4a.
Claim 14
Dependent Claim
18 words
The composition of claim 9, wherein said composition has an XRD pattern corresponding to that of FIG. 3d.
References Cited (Backward Citations)
FR2195586A1
Cited
GB1388236A
Cited
JPS5988351A
Cited
FR2537558A1
Cited
GB2132991A
Cited
JPS6036404A
Cited
US4612053A
Cited
US4693986A
Cited
JPS62275006A
Cited
JPS63100005A
Cited
JPH01250864A
Cited
JPH03112838A
Cited
US5322675A
Cited
FR2693716A1
Cited
WO1995008319A1
Cited
JPH09212044A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-11-03 | 2001-05-05 | 2001-11-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-11-03 | 2005-05-05 | 2005-11-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-11-03 | 2009-05-05 | 2009-11-04 | $7700.00 | Window Closed / Lapsed |