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US5676655A
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Methods for treating tinnitus by drug microinfusion from a neural prosthesis inserted in the brain
Assignee: University of Iowa Research Foundation
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Filing: 1996-02-06
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Granted: 1997-10-14
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Expires: 2016-02-06
Abstract
Abstract A method for implanting a neural prosthetic drug delivery apparatus into a target zone of a patient's brain for reducing or eliminating the effects of tinnitus. The apparatus includes a catheter which is inserted into the patient's auditory cortex or thalamus. The catheter microinfuses drugs which suppress or eliminate abnormal neural activity into geometrically separate locations of the patient's cortex or thalamus, thereby reducing or eliminating the effects of tinnitus.
Inventors
- 👤 Matthew A. Howard, III
- 👤 Timothy M. McCulloch
- 👤 Carol A. Bauer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 07:53
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/142; A61M5/14244; A61M5/14276; A61B; A61B18/00; A61B18/04; A61B18/12; A61B18/14; A61B18/148; A61F; A61F11/00; A61F5/00; A61F5/0003; A61F5/0013; A61F5/0026; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/05; A61N1/0526; A61N1/0529; A61N1/0531; A61N1/0539; A61N1/0541; A61N1/18; A61N1/32; A61N1/326; A61N1/36; A61N1/3605; A61N1/3606; A61N1/36082; A61N1/361; A61B2018/00315; A61B2018/00434; A61B2018/00571; A61B2018/00577; A61B2018/00636; A61B2018/00773; A61B2018/00839; A61B90/00; A61B90/10; A61F11/20; A61M2210/00; A61M2210/06; A61M2210/0693; A61M27/00; A61M27/002; A61M27/006; A61M5/1428; A61M5/168; A61M5/172; A61M5/1723
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
151 words
A method of treating a tinnitus patient, comprising the steps of: obtaining an image of a target zone of the patient's brain; inserting a catheter of a neural prosthetic apparatus into said target zone of the patient's brain using the image as a guide, said neural prosthetic apparatus comprising a drug reservoir for containing a drug, said drug reservoir coupled to said catheter, said catheter having a plurality of drug delivery ports for outputting said drug, said drug suppressing abnormal neural activity; providing a supply of said drug for outputting into said target zone of the patient's brain; outputting said drug into said target zone of the patient's brain; monitoring the patient's response to said drug outputted into said target zone of the patient's brain; and manually adjusting the amount of said drug outputted into said target zone of the patient's brain according to the patient's response to said drug outputted.
Claim 2
Independent Claim
151 words
A method of treating a tinnitus patient, comprising the steps of: obtaining an image of a target zone of the patient's brain; inserting a catheter of a neural prosthetic apparatus into said target zone of the patient's brain using the image as a guide, said neural prosthetic apparatus comprising a drug reservoir for containing a drug, said drug reservoir coupled to said catheter, said catheter having a plurality of drug delivery ports for outputting said drug, said drug suppressing abnormal neural activity; providing a supply of said drug for outputting into said target zone of the patient's brain; outputting said drug into said target zone of the patient's brain; monitoring the patient's response to said drug outputted into said target zone of the patient's brain; and manually adjusting the amount of said drug outputted into said target zone of the patient's brain according to the patient's response to said drug outputted.
Claim 3
Dependent Claim
134 words
The method of claim 1, wherein said inserting step comprises the steps of: inserting a catheter of a neural prosthetic apparatus into said target zone of the patient's brain, wherein said catheter includes a recording/stimulating electrode, said recording/stimulating electrode having a plurality of electrical contacts, said electrical contacts electrically coupled to a stimulation device, said stimulation device for outputting electrical signals; outputting electrical discharges from said plurality of electrical contacts, said electrical discharges outputted according to said electrical signals outputted from said stimulation device; receiving electrical discharges at said recording/stimulating electrode, said electrical discharges received from said target zone of the patient's brain; and positioning said catheter within said target zone of the patient's brain, said electrical discharges received providing physiologic confirmation of proper catheter position within said target zone of the patient's brain.
Claim 4
Dependent Claim
95 words
The method of claim 1, wherein said step of outputting said drug comprises the steps of: connecting said catheter to a pump-reservoir, said pump-reservoir for supplying said drug to said plurality of drug delivery ports; and pumping said drug from said pump-reservoir through said catheter to said plurality of drug delivery ports and infusing said drug from said plurality of drug delivery ports into geometrically separate locations within said target zone of the patient's brain, said geometrically separate locations corresponding to the respective external positions of said plurality of drug delivery ports on said catheter.
Claim 5
Dependent Claim
25 words
The method of claim 3, further comprising the steps of: locating said pump-reservoir beneath the patient's scalp; and securing said pump-reservoir to the patient's skull.
Claim 6
Dependent Claim
37 words
The method of claim 4, further comprising the step of recharging said pump-reservoir with said drug, said pump-reservoir including an externally accessible valve, said step of recharging comprising injecting said drug into said pump-reservoir through said valve.
Claim 7
Dependent Claim
51 words
The method of claim 3, wherein said pumping step comprises the step of adjusting the rate of said pumping said drug, the rate of said pumping said drug adjusted according to the patient's response to said drug, said drug capable of suppressing abnormal neural activity and alleviating the symptoms of tinnitus.
Claim 8
Dependent Claim
27 words
The method of claim 6, wherein said adjusting the rate of said pumping said drug step comprises adjusting the rate of said pumping by percutaneous radio control.
Claim 9
Dependent Claim
71 words
The method of claim 1, wherein said obtaining step comprises obtaining an image of said target zone of the patient's brain, said target zone including one of an ordinary cortex and a medial geniculate nucleus of a thalamus, and said inserting step comprises inserting the catheter into said target zone of the patient's brain, said target zone including one of the auditory cortex and the medial geniculate nucleus of the thalamus.
Claim 10
Dependent Claim
34 words
The method of claim 1, wherein said step of outputting said drug comprises outputting a drug which blocks abnormal neural activity, said drug including one of an anticonvulsant, a neurotransmitter, and a local anesthetic.
Claim 11
Dependent Claim
100 words
The method of claim 1, wherein said step of obtaining an image of a target zone of the patient's brain comprises: acquiring digital data corresponding to a three dimensional digital image of the patient's brain; storing said digital data corresponding to said three dimensional digital image in a memory of a computer; transforming said digital data corresponding to from said three dimensional digital image to yield transformed digital data, said transformed digital data corresponding to a modified three dimensional digital image, said modified three dimensional digital image showing the location and orientation of said target zone of the patient's brain.
Claim 12
Dependent Claim
166 words
The method of claim 1, wherein said inserting step comprises the steps of: a) inserting a catheter of a neural prosthetic apparatus into said target zone of the patient's brain, wherein said catheter includes a recording/stimulating electrode, said recording/stimulating electrode having a plurality of electrical contacts, said plurality of electrical contacts electrically coupled to a stimulation device, said stimulation device for outputting electrical signals; b) outputting electrical discharges from said plurality of electrical contacts, said electrical discharges outputted from said plurality of electrical contacts according to said electrical signals outputted from said stimulation device; c) monitoring the patient's response to said electrical discharges outputted from said plurality of electrical contacts; d) adjusting the position of said catheter within said target zone of the patient's brain according to the patient's response to said electrical discharges outputted from said plurality of electrical contacts; and e) repeating steps b), c) and d) until the proper position of said catheter within said target zone of the patient's brain is achieved.
Claim 13
Dependent Claim
187 words
The method of claim 1, wherein said inserting step comprises the steps of: a) inserting a catheter of a neural prosthetic apparatus into said target zone of the patient's brain, wherein said catheter includes a recording/stimulating electrode, said recording/stimulating electrode having a plurality of electrical contacts, each of said plurality of electrical contacts capable of receiving electrical discharges from said target zone of the patient's brain, and said neural prosthetic apparatus capable of recording said electrical discharges received from said target zone of the patient's brain; b) receiving electrical discharges at said plurality of electrical contacts, said electrical discharges received according to the position of said catheter within said target zone of the patient's brain; c) recording the position on said catheter of said electrical contacts receiving said electrical discharges received; d) adjusting the position of said catheter within said target zone of the patient's brain according to the position on said catheter of said electrical contacts receiving said electrical discharges received; and e) repeating steps b), c) and d) until the proper position of said catheter within said target zone of the patient's brain is achieved.
References Cited (Backward Citations)
US4360019A
Cited
US4357497A
Cited
US4490137A
Cited
US4735968A
Cited
EP0259906A2
Cited
US5000194A
Cited
US5271397A
Cited
US5221283A
Cited
US5496369A
Cited
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