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US5675003A Expired / Lapsed US ⏱️ 0.0 years remaining

3-ammoniopropenyl cephalosporin compounds as antibacterial agents

Assignee: Korea Institute of Science and Technology
•
Filing: 1995-09-01
•
Granted: 1997-10-07
•
Expires: 2015-09-01
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Abstract

Abstract A 3-ammoniopropenyl cephalosporin of the following formula (I): <IMAGE> (I) wherein P is hydroxylated alicyclic or aliphatic amines such as meso-3,4-dihydroxy-1-methylpyrrolidine, (3S,4S)-3,4-dihydroxy-1-methylpyrrolidine, (3R,4R)-3,4-dihydroxy-1-methylpyrrolidine, rac-3,4-trans-dihydroxy-1-methylpyrrlidine, (2S,4R)-4-hydroxy-1-methyl-2-pyrrolidinemethanol, N-methyl-bis(2-hydroxyethyl)amine, 3,4-cis-dihydroxy-1-methylpiperidine, 3,4-trans-dihydroxypiperidine, 4-hydroxy-1-methylpiperidine, 2-hydroxymethyl-1-methylpiperidine, or tropine, or a pharmaceutically acceptable salt thereof, exhibits good anti-bacterial activities against a wide variety of Gram-positive and Gram-negative bacteria; and a process for the preparation thereof.

Inventors

  • 👤 Hokoon Park
  • 👤 Yong Sup Lee
  • 👤 Jae Yeol Lee
  • 👤 Dae Hwan Suk
  • 👤 Eun-Rhan Woo

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-07 12:56
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D501/24; A; A61; A61P; A61P31/00; A61P31/04; C07D501/48; C07D501/56

Claims Analysis

Total Claims: 2
Claim 1
Independent Claim 36 words
A 3-propenyl cephalosporin compound of the following formula (I) ##STR14## wherein, P is selected from the group consisting of meso-3,4-dihydroxy-1-methylpyrrolidine, (3S,4S)-3,4-dihydroxy-1-methylpyrrolidine, (3R,4R)-3,4-dihydroxy-1-methylpyrrolidine, rac-3,4-trans-dihydroxy-1-methylpyrrolidine, (2S,4R)-4-hydroxy-1-methyl-2-pyrrolidinemethanol, N-methyl-bis(2-hydroxyethyl)amine,3,4-cis-dihydroxy-1-methylpiperidine, 3,4-trans-dihydroxypiperidine, 4-hydroxy-1-methylpiperidine, 2-hydroxymethyl-1-methylpiperidine, and tropine, or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim 36 words
A 3-propenyl cephalosporin compound of the following formula (I) ##STR14## wherein, P is selected from the group consisting of meso-3,4-dihydroxy-1-methylpyrrolidine, (3S,4S)-3,4-dihydroxy-1-methylpyrrolidine, (3R,4R)-3,4-dihydroxy-1-methylpyrrolidine, rac-3,4-trans-dihydroxy-1-methylpyrrolidine, (2S,4R)-4-hydroxy-1-methyl-2-pyrrolidinemethanol, N-methyl-bis(2-hydroxyethyl)amine,3,4-cis-dihydroxy-1-methylpiperidine, 3,4-trans-dihydroxypiperidine, 4-hydroxy-1-methylpiperidine, 2-hydroxymethyl-1-methylpiperidine, and tropine, or a pharmaceutically acceptable salt thereof.

References Cited (Backward Citations)

US4912212A Cited
US4278671A Cited
JPS54154786A Cited
EP0462009A1 Cited
EP0528343A2 Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 2000-10-06 2001-04-07 2001-10-07 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2004-10-06 2005-04-07 2005-10-07 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2008-10-06 2009-04-07 2009-10-07 $7700.00 Window Closed / Lapsed

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