Patent US2247712A successfully refreshed from Google Patents.
Patent US5668154A successfully refreshed from Google Patents.
US5668154A
Expired / Lapsed
US
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Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles
Assignee: Aventis Pharmaceuticals Inc
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Filing: 1996-05-02
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Granted: 1997-09-16
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Expires: 2016-05-02
Abstract
Abstract Novel pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the 1,2-benzisoxazoles and -benzisothiazoles and intermediates, or compositions thereof are disclosed.
Inventors
- 👤 David M. Fink
- 👤 Barbara E. Kurys
- 👤 Gregory M. Shutske
- 👤 John D. Tomer, IV
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 15:04
CPC Classifications
C; C07; C07D; C07D231/00; C07D231/54; C07D231/56; A; A61; A61P; A61P25/00; A61P25/18; A61P25/24; A61P25/28; C07D261/00; C07D261/20; C07D413/00; C07D413/02; C07D413/12; C07D413/14; C07D417/00; C07D417/02; C07D417/12
Claims Analysis
Total Claims: 46
Claim 1
Independent Claim
65 words
A compound of the formula: wherein R 1 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, lowercycloalkyl, --C(═O)O-loweralkyl, 1,3-dioxolane, phenyl, cinnamyl, phenyl substituted by loweralkyl, loweralkoxy, halogen, hydroxyl, nitro or trifluoromethyl; Q is hydrogen, halogen, loweralkyl or nitro; X is oxygen; Z is hydrogen, loweralkyl, loweralkoxy, hydroxyl, halogen, nitro, or trifluoromethyl; n is 1 to 12; the geometric isomers, the optical isomers, or the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
65 words
A compound of the formula: wherein R 1 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, lowercycloalkyl, --C(═O)O-loweralkyl, 1,3-dioxolane, phenyl, cinnamyl, phenyl substituted by loweralkyl, loweralkoxy, halogen, hydroxyl, nitro or trifluoromethyl; Q is hydrogen, halogen, loweralkyl or nitro; X is oxygen; Z is hydrogen, loweralkyl, loweralkoxy, hydroxyl, halogen, nitro, or trifluoromethyl; n is 1 to 12; the geometric isomers, the optical isomers, or the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
26 words
A compound according to claim 1 wherein R 1 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, lowercycloalkyl, phenyl, phenyl substituted by loweralkyl, loweralkoxy, halogen, hydroxyl, nitro or trifluoromethyl.
Claim 4
Dependent Claim
17 words
A compound according to claim 2 wherein X is oxygen and R 1 is hydrogen or loweralkyl.
Claim 5
Dependent Claim
26 words
A compound according to claim 2 wherein X is oxygen and R 1 is phenyl or phenyl substituted by loweralkyl, loweralkoxy, halogen, hydroxyl, nitro or trifluoromethyl.
Claim 6
Dependent Claim
9 words
A compound according to claim 2 which is 6-chloro-3-[1-propyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazote.
Claim 7
Dependent Claim
10 words
A compound according to claim 2 which is 3-[1-(4,4-dimethylpentyl-N-4(1H )-pyridiniminyl]-1,2-benzisoxazole.
Claim 8
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(phenylmethyl)-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 9
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(2-phenylethy)l-N-4(1H)-pyridiniminyl]-1,2benzisoxazole.
Claim 10
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(3-phenylpropyl)-N-(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 11
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(4-phenylbutyl)-N-(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 12
Dependent Claim
10 words
A compound according to claim 2 which is 3-[1-(5-phenylpentyl)-N-(1H)-pyridiniminyl-1,2-benzis oxazole.
Claim 13
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(2-methylphenyl)methyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 14
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(4-methylphenyl)methyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 15
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(3-methylphenyl)methyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 16
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(3-methoxyphenyl)methyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 17
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(3-fluorophenyl)methyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 18
Dependent Claim
10 words
A compound according to claim 2 which is 3-[1-(2-fluoropheny])methyl-N-4( 1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 19
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(4-fluorophenyl)methyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 20
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(3-nitrophenyl)methyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 21
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(2-nitrophenyl)methyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 22
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(4-trifluormethylphenyl)methyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 23
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(3-trifluoromethylphenyl)methyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 24
Dependent Claim
9 words
A compound according to claim 2 which is 5-fluoro-3-[1-phenylmethyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 25
Dependent Claim
9 words
A compound according to claim 2 which is 6-methoxy-3-[1-phenylmethyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 26
Dependent Claim
9 words
A compound according to claim 2 which is 6-nitro-3-[1-phenylmethyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 27
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(2-butynyl)-N-(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 28
Dependent Claim
5 words
A compound which is 3-[1-(3-bromo-2-butenyl)-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 29
Dependent Claim
5 words
A compound which is 3-[1-(3-bromo-2-butenyl)-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 30
Dependent Claim
9 words
A compound according to claim 2 which is 7-fluoro-3-[1-phenylmethyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 31
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(2-propenyl)-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 32
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(phenylmethyl)-N-(1H)-pyridiniminyl]-6-trifluoromethyl-1,2-benzisoxazole.
Claim 33
Dependent Claim
9 words
A compound according to claim 2 which is 3-[1-(phenylmethyl)-N-4(1H)-pyridiniminyl]-5-trifluoromethyl-1,2-benzisoxazole.
Claim 34
Dependent Claim
10 words
A compound according to claim 2 which is 6-methoxy-3-[1-phenylmethyl-N-(1H)-3-bromo-pyridiniminyl]- 1,2-benzisoxazole.
Claim 35
Dependent Claim
9 words
A compound according to claim 2 which is 6-fluoro-3-[1-phenylmethyl-N-(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 36
Dependent Claim
10 words
A compound according to claim 2 which is 3-[1-phenylmethyl-N-4(1H)-pyridiniminyl]-7-trifluoromethyl- 1,2-benzisoxazole.
Claim 37
Dependent Claim
9 words
A compound according to claim 2 which is 5-methoxy-3-[1-phenylmethyl-N-(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 38
Dependent Claim
12 words
A compound according to claim 1 which is [4-(3-benzoisoxazolylimino)--(4H)-pyridinyl]-acetic acid methyl ester.
Claim 39
Dependent Claim
9 words
A compound according to claim 2 which is 7-methoxy-3-[1-phenylmethyl-N-(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 40
Dependent Claim
9 words
A compound according to claim 2 which is 4-fluoro-3-[1-phenylmethyl-N-(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 41
Dependent Claim
9 words
A compound according to claim 2 which is 6-fluoro-3-[1-methyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 42
Dependent Claim
9 words
A compound according to claim 2 which is 6-methoxy-3-[1-methyl-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 43
Dependent Claim
9 words
A compound according to claim 1 which is 3-[1-(trans-3-phenyl-2-propenyl)-N-4(1H)-pyridiniminyl]-1,2-benzisoxazole.
Claim 44
Dependent Claim
9 words
A compound according to claim 1 which is 3-[1-[2-(1,3-dioxalane)ethyl]-N-(1)-pyridiniminyl]-1,2-benzisoxazole.
Claim 45
Dependent Claim
25 words
A memory dysfunction relieving composition comprising an adjuvant and as the active ingredient, a memory dysfunction relieving effective amount of a compound of claim 1.
Claim 46
Dependent Claim
29 words
A method of relieving memory dysfunction in mammals comprising administering to a mammal requiring memory dysfunction relief, a memory dysfunction relieving effective amount of a compound of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-09-15 | 2001-03-17 | 2001-09-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-09-15 | 2005-03-17 | 2005-09-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-09-15 | 2009-03-17 | 2009-09-16 | $7700.00 | Window Closed / Lapsed |