US5665728A
Expired / Lapsed
US
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Method of treating hyperproliferative vascular disease
Assignee: Wyeth LLC
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Filing: 1995-05-26
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Granted: 1997-09-09
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Expires: 2015-05-26
Abstract
Abstract This invention provides a method of preventing or treating hyperproliferative vascular disease in a mammal by administering an antiproliferative effective amount of rapamycin alone or in combination with mycophenolic acid.
Inventors
- 👤 Randall Ellis Morris
- 👤 Clare Robert Gregory
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 05:18
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/70; A61K31/7042; A61K31/7052; A61K31/706; A61K31/395; A61K31/435; A61K31/4353; A61K31/436; A61K45/00; A61K45/06; A61P; A61P7/00; A61P7/02; A61P9/00; A61P9/10
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
70 words
A method of treating a hyperproliferative vascular disease selected from the group consisting of intimal smooth muscle cell proliferation, restenosis, and vascular occlusion, wherein the intimal smooth muscle cell proliferation, restenosis, or vascular occlusion is caused by an infectious disorder, hypothermia, or irradiation, which comprises administering an antiproliferative effective amount of rapamycin to said mammal orally, parenterally, intravascularly, intranasally, intrabronchially, transdermally, rectally, or via a vascular stent impregnated with rapamycin.
Claim 2
Independent Claim
70 words
A method of treating a hyperproliferative vascular disease selected from the group consisting of intimal smooth muscle cell proliferation, restenosis, and vascular occlusion, wherein the intimal smooth muscle cell proliferation, restenosis, or vascular occlusion is caused by an infectious disorder, hypothermia, or irradiation, which comprises administering an antiproliferative effective amount of rapamycin to said mammal orally, parenterally, intravascularly, intranasally, intrabronchially, transdermally, rectally, or via a vascular stent impregnated with rapamycin.
Claim 3
Independent Claim
76 words
A method of treating a hyperproliferative vascular disease selected from the group consisting of intimal smooth muscle cell proliferation, restenosis, and vascular occlusion, wherein the intimal smooth muscle cell proliferation, restenosis, or vascular occlusion is caused by vascular catheterization, vascular scraping, percutaneous transluminal/coronary angioplasty, vascular surgery, or laser treatment, which comprises, administering an antiproliferative effective amount of rapamycin to said mammal orally, parenterally, intravascularly, intranasally, intrabronchially, transdermally, rectally, or via a vascular stent impregnated with rapamycin.
Claim 4
Independent Claim
76 words
A method of treating a hyperproliferative vascular disease selected from the group consisting of intimal smooth muscle cell proliferation, restenosis, and vascular occlusion, wherein the intimal smooth muscle cell proliferation, restenosis, or vascular occlusion is caused by vascular catheterization, vascular scraping, percutaneous transluminal/coronary angioplasty, vascular surgery, or laser treatment, which comprises, administering an antiproliferative effective amount of rapamycin to said mammal orally, parenterally, intravascularly, intranasally, intrabronchially, transdermally, rectally, or via a vascular stent impregnated with rapamycin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-09-08 | 2001-03-10 | 2001-09-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-09-08 | 2005-03-10 | 2005-09-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-09-08 | 2009-03-10 | 2009-09-09 | $7700.00 | Window Closed / Lapsed |