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US5665383A
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Methods for the preparation of immunostimulating agents for in vivo delivery
Assignee: Abraxis Bioscience LLC
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Filing: 1995-06-07
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Granted: 1997-09-09
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Expires: 2015-06-07
Abstract
Abstract In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
Inventors
- 👤 Mark W. Grinstaff
- 👤 Patrick Soon-Shiong
- 👤 Michael Wong
- 👤 Paul A. Sandford
- 👤 Kenneth S. Suslick
- 👤 Neil P. Desai
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 16:44
CPC Classifications
A; A23; A23L; A23L33/00; A23L33/40; A61; A61K; A61K47/00; A61K47/50; A61K47/69; A61K47/6921; A61K47/6925; A61K47/6927; A61K49/00; A61K49/06; A61K49/08; A61K49/10; A61K49/12; A61K49/126; A61K49/18; A61K49/1818; A61K49/1821; A61K49/1824; A61K49/1827; A61K49/1851; A61K49/1863; A61K49/22; A61K49/222; A61K49/223; A61K49/226; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5052; A61K9/51; A61K9/5107; A61K9/513; A61K9/5138; A61K9/5146; A61K9/5161; A61K9/5169; B; B82; B82Y; B82Y5/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
80 words
A method for the preparation of immunostimulating agents for in vivo delivery, wherein said method comprises subjecting aqueous medium containing biocompatible material capable of being crosslinked by disulfide bonds and an immunostimulating agent to high intensity ultrasound conditions for a time sufficient to promote crosslinking of said biocompatible material by disulfide bonds; wherein said immunostimulating agent is substantially completely contained within a polymeric shell, and wherein the largest cross-sectional dimension of said shell is no greater than about 10 microns.
Claim 2
Independent Claim
80 words
A method for the preparation of immunostimulating agents for in vivo delivery, wherein said method comprises subjecting aqueous medium containing biocompatible material capable of being crosslinked by disulfide bonds and an immunostimulating agent to high intensity ultrasound conditions for a time sufficient to promote crosslinking of said biocompatible material by disulfide bonds; wherein said immunostimulating agent is substantially completely contained within a polymeric shell, and wherein the largest cross-sectional dimension of said shell is no greater than about 10 microns.
Claim 3
Dependent Claim
37 words
The method according to claim 1, wherein said biocompatible material is a naturally occurring polymer, a synthetic polymer, or a combination thereof, wherein said polymer, prior to crosslinking, has covalently attached thereto sulfhydryl groups or disulfide linkages.
Claim 4
Dependent Claim
51 words
The method according to claim 2, wherein said naturally occurring polymer is selected from proteins containing sulfhydryl groups and/or disulfide groups, polypeptides containing sulfhydryl groups and/or disulfide groups, lipids containing sulfhydryl groups and/or disulfide groups, polynucleic acids containing sulfhydryl groups and/or disulfide groups, or polysaccharides containing sulfhydryl groups and/or disulfide groups.
Claim 5
Dependent Claim
30 words
The method according to claim 3, wherein said protein is selected from hemoglobin, myoglobin, albumin, insulin, lysozyme, immunoglobulins, alpha-2-macroglobulin, fibronectin, vitronectin, fibrinogen, or combinations of any two or more thereof.
Claim 6
Dependent Claim
11 words
The method according to claim 4, wherein said protein is albumin.
Claim 7
Dependent Claim
11 words
The method according to claim 4, wherein said protein is hemoglobin.
Claim 8
Dependent Claim
16 words
The method according to claim 4, wherein said protein is a combination of albumin and hemoglobin.
Claim 9
Dependent Claim
13 words
The method according to claim 1, wherein said immunostimulating agent is a vaccine.
Claim 10
Dependent Claim
51 words
A method for the delivery of an immunostimulating agent to a subject in need thereof, said method comprising administering to said subject the immunostimulating agent prepared by the method of claim 1 by oral, intravenous, subcutaneous, intraperitoneal, intrathecal, intramuscular, intracranial, inhalational, topical, transdermal, suppository (rectal), or pessary (vaginal) routes of administration.
References Cited (Backward Citations)
US5439686A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2000-09-08 | 2001-03-10 | 2001-09-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-09-08 | 2005-03-10 | 2005-09-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-09-08 | 2009-03-10 | 2009-09-09 | $7700.00 | Window Closed / Lapsed |