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US5665364A Expired / Lapsed US ⏱️ 0.0 years remaining

Compositions for topical delivery of active ingredients

Assignee: Procter and Gamble Co
•
Filing: 1995-07-24
•
Granted: 1997-09-09
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Expires: 2015-07-24
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Abstract

Abstract The compositions of the present invention are useful for the topical delivery of a wide variety of active ingredients. These compositions are particularly useful for treating conditions such as acne and its attendant skin lesions, blemishes, and other imperfections. These compositions are nonirritating to the skin and also provide improved skin feel benefits. These compositions can be in the form of leave-on products and products that are rinsed or wiped from the skin after use.

Inventors

  • 👤 David Michael McAtee
  • 👤 Lourdes Dessus Albacarys
  • 👤 Joseph Anthony Listro

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-08 08:55
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/44; A61K8/442; A61K8/33; A61K8/36; A61K8/368; A61K8/41; A61K8/416; A61K8/46; A61K8/463; A61K8/466; A61P; A61P17/00; A61P17/02; A61Q; A61Q19/00; A61Q19/10; A61K2800/00; A61K2800/40; A61K2800/59; A61K2800/596

Claims Analysis

Total Claims: 24
Claim 1
Independent Claim 179 words
A topical personal care composition comprising: (a) from about 0.1% to about 20% by weight of an amphoteric surfactant having the following structure ##STR11## wherein R 1 is unsubstituted, saturated or unsaturated, straight or branched chain alkyl having from about 9 to about 22 carbon atoms; m is an integer from 1 to about 3; n is 0 or 1; R 2 and R 3 are independently selected from alkyl having from 1 to about 3 carbon atoms and monohydroxyalkyl having from 1 to about 3 carbon atoms; R 4 is selected from saturated or unsaturated alkyl having from 1 to about 5 carbon atoms and saturated or unsaturated monohydroxyalkyl having from 1 to about 5 carbon atoms; X is selected form the group consisting of CO 2 , SO 3 , and SO 4 ; and pharmaceutically acceptable salts of the foregoing compounds; (b) from about 0.1% to about 20% by weight of an anionic surfactant, (c) from about 0.001% to about 20% of an active ingredient, and (d) from about 40% to about 99.799% by weight water.
Claim 2
Dependent Claim 179 words
A topical personal care composition comprising: (a) from about 0.1% to about 20% by weight of an amphoteric surfactant having the following structure ##STR11## wherein R 1 is unsubstituted, saturated or unsaturated, straight or branched chain alkyl having from about 9 to about 22 carbon atoms; m is an integer from 1 to about 3; n is 0 or 1; R 2 and R 3 are independently selected from alkyl having from 1 to about 3 carbon atoms and monohydroxyalkyl having from 1 to about 3 carbon atoms; R 4 is selected from saturated or unsaturated alkyl having from 1 to about 5 carbon atoms and saturated or unsaturated monohydroxyalkyl having from 1 to about 5 carbon atoms; X is selected form the group consisting of CO 2 , SO 3 , and SO 4 ; and pharmaceutically acceptable salts of the foregoing compounds; (b) from about 0.1% to about 20% by weight of an anionic surfactant, (c) from about 0.001% to about 20% of an active ingredient, and (d) from about 40% to about 99.799% by weight water.
Claim 3
Dependent Claim 57 words
A composition according to claim 1 wherein for said amphoteric surfactant in (a), R 2 and R 3 are selected from the group consisting of CH 3 , CH 2 CH 2 OH and CH 2 CH 2 CH 2 OH; X is selected from CO 2 and SO 3 ; and m is 2 or 3.
Claim 4
Dependent Claim 55 words
A composition according to claim 2 wherein R 2 and R 3 are selected from the group consisting of CH 3 , CH 2 CH 2 OH, and CH 2 CH 2 CH 2 OH; X is selected from the group consisting of CO 2 and SO 3 , and m is 2 or 3.
Claim 5
Dependent Claim 41 words
A composition according to claim 3 wherein R 4 has from 1 to about 3 carbon atoms when X is CO 2 , and R 4 has from about 2 to about 4 carbon atoms when X is SO 3 .
Claim 6
Dependent Claim 53 words
A composition according to claim 4 wherein R 1 has from about 11 to about 18 carbon atoms; R 2 and R 3 are CH 3 ; and R 4 has 1 carbon atom when X is CO 2 , and R 4 has 3 carbon a when X is SO 3 .
Claim 7
Dependent Claim 25 words
A composition according to claim 5 wherein R 4 has 1 carbon atom, X is CO 2 , m is 3, and n is 1.
Claim 8
Dependent Claim 25 words
A composition according to claim 5 wherein R 4 has 3 carbon atoms, X is SO 3 , m is 3 and n is 1.
Claim 9
Dependent Claim 31 words
A composition according to claim 1 where said amphoteric surfactant is selected from the group consisting of cetyl dimethyl betaine, cocoamidopropyl betaine, stearyl dimethyl betaine, cocoamidopropyl hydroxy sultaine, and mixtures thereof.
Claim 10
Dependent Claim 14 words
A composition according to claim 1 wherein the amphoteric surfactant is cetyl dimethyl betaine.
Claim 11
Dependent Claim 35 words
A composition according to claim 1 wherein said anionic surfactant is selected from the group consisting of sodium lauryl sulfate, sodium cetyl sulfate, ammonium cocoyl isethionate, sodium lauroyl isethionate, sodium lauroyl sarcosinate, and mixtures thereof.
Claim 12
Dependent Claim 14 words
A composition according to claim 10 wherein said anionic surfactant is sodium lauryl sulfate.
Claim 13
Dependent Claim 58 words
A composition according to claim 9 wherein said active ingredient is selected from the group consisting of selected from the group consisting of salicylic acid, benzoyl peroxide, cis-retinoic acid, retinol, phytic acid, trans-retinoic acid, N-acetyl L-cysteine, azelaic acid, lipoic acid, resorcinol, lactic acid, glycolic acid, ibuprofen, naproxen, hydrocortisone, phenoxyethanol, phenoxypropanol, phenoxyisopropanol, 2,4,4'-trichloro-2'-hydroxy diphenyl ether, 3,4,4'-trichlorocarbanilide, and mixtures thereof.
Claim 14
Dependent Claim 24 words
A composition according to claim 12 wherein said active ingredient is selected from the group consisting of salicylic acid, benzoyl peroxide, and mixtures thereof.
Claim 15
Dependent Claim 21 words
A composition according to claim 1 wherein said composition further comprises from about 0.1% to about 20% of a cationic surfactant.
Claim 16
Dependent Claim 102 words
A composition according to claim 14 wherein said cationic surfactant has the formula: ##STR12## wherein in this formula for said cationic surfactant, R 1 is an allkyl group having from about 12 to about 22 carbon atoms, R 2 is H or an alkyl group having from about 1 to about 22 carbon atoms, R 3 and R 4 are independently selected from H or an alkyl group having from about 1 to about 3 carbon atoms, and X is an anion selected from chloride, bromide, iodide, acetate, phosphate, nitrate, sulfate, methyl sulfate, ethyl sulfate, tosylate, lactate, citrate, glycolate, and mixtures thereof.
Claim 17
Dependent Claim 36 words
A composition according to claim 15 wherein said cationic surfactant is selected from the group consisting of dilauryl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, dimyristyl dimethyl ammonium chloride, dipalmityl dimethyl ammonium chloride, and mixtures thereof.
Claim 18
Dependent Claim 20 words
A composition according to claim 14 wherein said composition further comprises from about 0.1% to about 20% of a humectant.
Claim 19
Dependent Claim 11 words
A composition according to claim 17 wherein said humectant is glycerol.
Claim 20
Dependent Claim 29 words
A method for treating skin comprising the step of applying to the skin from about 0.5 mg/cm 2 to about 25 mg/cm 2 of the composition of claim 1.
Claim 21
Dependent Claim 29 words
A method for treating acne comprising the step of applying to the skin from about 0.5 mg/cm 2 to about 25 mg/cm 2 of the composition of claim 1.
Claim 22
Dependent Claim 41 words
A method for cleansing skin comprising the steps of (i) applying to the skin from about 0.5 mg/cm 2 to about 25 mg/cm 2 of the composition of claim 1, and (ii) rinsing the composition of claim 1 from the skin.
Claim 23
Dependent Claim 41 words
A method for cleansing skin comprising the steps of: (i) applying to the skin from about 0.5 mg/cm 2 to about 25 mg/cm 2 of the composition of claim 1, and (ii) wiping the composition of claim 1 from the skin.
Claim 24
Dependent Claim 55 words
A method of preparing a composition according to claim 1 comprising the steps of: (i) combining an aqueous solution of said amphoteric surfactant and an aqueous solution of said anionic surfactant to form an aqueous solution of a complex of said amphoteric and said anionic surfactant, and (ii) combining said complex with said active ingredient.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 2000-09-08 2001-03-10 2001-09-09 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2004-09-08 2005-03-10 2005-09-09 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2008-09-08 2009-03-10 2009-09-09 $7700.00 Window Closed / Lapsed

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