Patent US5657255A successfully refreshed from Google Patents.
US5657255A
Expired / Lapsed
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Hierarchical biological modelling system and method
Assignee: Interleukin Genetics Inc
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Filing: 1995-04-14
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Granted: 1997-08-12
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Expires: 2015-04-14
Abstract
Abstract A hierarchical biological modelling system and method provides integrated levels of information synthesized from multiple sources. An executable model of a biological system is developed from information and structures based on the multiple sources. The model is balanced to ensure that it matches the information and structures. Once the model is created and balanced it can be used to provide insight into phenomena at the cellular, or subcellular level, as well as phenomena at the patient, organ and system levels. From this information clinical trials can be emulated, biologic targets for drug development can be identified and subcellular phenomena over time can be observed. The model provides an integrated view of a multi-variable biological system.
Inventors
- 👤 Pamela K. Fink
- 👤 Kenneth S. Kornman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 16:49
CPC Classifications
C; C07; C07K; C07K1/00; G; G16; G16B; G16B5/00; G16B5/20; G16B5/30; G16C; G16C20/00; G16C20/10; G16H; G16H50/00; G16H50/50; G16H10/00; G16H10/20; G16H40/00; G16H40/60; G16H40/63; G16H70/00; G16H70/60
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
93 words
An interactive computer-implemented system for modelling a dynamic multi-variable biological system from the cellular, or subcellular, to the human or patient population level, wherein the biological system is controlled by a plurality of interrelated biologic processes defining functions occurring within the biological system, comprising: one or more levels, each level comprising one or more distinct linkable entities representing biologic processes, and each level having a respective level of biologic complexity; and a human interface for interacting with said one or more levels to create an executable model of the dynamic multi-variable biological system.
Claim 2
Dependent Claim
93 words
An interactive computer-implemented system for modelling a dynamic multi-variable biological system from the cellular, or subcellular, to the human or patient population level, wherein the biological system is controlled by a plurality of interrelated biologic processes defining functions occurring within the biological system, comprising: one or more levels, each level comprising one or more distinct linkable entities representing biologic processes, and each level having a respective level of biologic complexity; and a human interface for interacting with said one or more levels to create an executable model of the dynamic multi-variable biological system.
Claim 3
Dependent Claim
34 words
The interactive computer-implemented system of claim 1, wherein said one or more levels comprise two or more levels having links between said levels for navigating information between said levels during execution of the model.
Claim 4
Dependent Claim
30 words
The interactive computer-implemented system of claim 1, wherein said one or more levels comprises two or more levels having links between levels for providing model information to the human interface.
Claim 5
Dependent Claim
14 words
The interactive computer-implemented system of claim 1, wherein said entities comprise interactive graphical entities.
Claim 6
Dependent Claim
24 words
The interactive computer-implemented system of claim 4, wherein said interactive graphical entities synthesize information for use by other graphical entities on the same level.
Claim 7
Dependent Claim
23 words
The interactive computer-implemented system of claim 4, wherein said interactive graphical entities synthesize information for use by other graphical entities on other levels.
Claim 8
Dependent Claim
22 words
The interactive computer-implemented system of claim 1, wherein said human interface includes: an input mechanism for altering information used by the model.
Claim 9
Dependent Claim
21 words
The interactive computer-implemented system of claim 1, wherein said human interface includes: an output mechanism for viewing information from the model.
Claim 10
Independent Claim
168 words
A method of creating an executable computer-implemented model for modelling a dynamic multi-variable biological system from the cellular, or subcellular, to the human or patient population level, wherein the biological system is controlled by a plurality of interrelated biologic processes defining functions occurring within the biological system, comprising: (a) creating at least one knowledge diagram and a reference biologic pattern from one or more sources of information related to biological phenomena, said knowledge diagram defining the biological system by including one or more linkable entities representing distinct biological processes; (b) developing an executable interactive model based on said knowledge diagram; (c) executing said interactive model to ensure that the interactive model is behaving in a desirable and appropriate manner; (d) checking said interactive model against the reference biologic pattern; (e) if said checking indicates inconsistency with the reference biologic pattern, modifying said executable interactive model and repeating steps (c) and (d); and (f) if said checking indicates consistency with the reference biologic pattern, using said executable interactive model.
Claim 11
Independent Claim
168 words
A method of creating an executable computer-implemented model for modelling a dynamic multi-variable biological system from the cellular, or subcellular, to the human or patient population level, wherein the biological system is controlled by a plurality of interrelated biologic processes defining functions occurring within the biological system, comprising: (a) creating at least one knowledge diagram and a reference biologic pattern from one or more sources of information related to biological phenomena, said knowledge diagram defining the biological system by including one or more linkable entities representing distinct biological processes; (b) developing an executable interactive model based on said knowledge diagram; (c) executing said interactive model to ensure that the interactive model is behaving in a desirable and appropriate manner; (d) checking said interactive model against the reference biologic pattern; (e) if said checking indicates inconsistency with the reference biologic pattern, modifying said executable interactive model and repeating steps (c) and (d); and (f) if said checking indicates consistency with the reference biologic pattern, using said executable interactive model.
Claim 12
Dependent Claim
57 words
The method of creating an executable computer-implemented model according to claim 9, wherein said step of developing an executable interactive model includes the step of creating one or more executable levels, each level comprising one or more linkable entities representing a biologic process from said reference biologic pattern, and each level having a respective level of complexity.
Claim 13
Dependent Claim
28 words
The method of creating an executable computer-implemented model according to claim 9, wherein said step of creating a reference biologic pattern includes developing knowledge diagrams representing biologic processes.
Claim 14
Dependent Claim
34 words
The method of creating an executable computer-implemented model according to claim 9, wherein said step of developing an executable interactive model includes the step of linking two or more models representing different biologic systems.
Claim 15
Dependent Claim
26 words
The method of creating an executable computer-implemented model according to claim 9, further including the step of applying said executable interactive model to develop clinical trials.
Claim 16
Dependent Claim
25 words
The method of creating an executable computer-implemented model according to claim 9, further including the step of applying said executable interactive model to develop drugs.
Claim 17
Independent Claim
126 words
A method for designing clinical trials, comprising the steps of: developing an interactive computer-implemented system for modelling a dynamic multi-variable biological system from the cellular, or subcellular, to the human or patient population level, wherein the biological system is controlled by a plurality of interrelated biologic processes defining functions occurring within the biological system, wherein said computer-implemented system includes one or more levels, each level comprising one or more distinct linkable entities representing biologic processes, and each level having a respective level of complexity, and a human interface for interacting with said one or more levels; and applying said interactive computer-implemented system to design clinical trials, wherein said interactive computer-implemented system considers various patient and treatment characteristics to identify patients that would benefit from specific treatments.
Claim 18
Independent Claim
126 words
A method for designing clinical trials, comprising the steps of: developing an interactive computer-implemented system for modelling a dynamic multi-variable biological system from the cellular, or subcellular, to the human or patient population level, wherein the biological system is controlled by a plurality of interrelated biologic processes defining functions occurring within the biological system, wherein said computer-implemented system includes one or more levels, each level comprising one or more distinct linkable entities representing biologic processes, and each level having a respective level of complexity, and a human interface for interacting with said one or more levels; and applying said interactive computer-implemented system to design clinical trials, wherein said interactive computer-implemented system considers various patient and treatment characteristics to identify patients that would benefit from specific treatments.
Claim 19
Independent Claim
127 words
A method for use in drug development, comprising the steps of: developing an interactive computer-implemented system for modelling a dynamic multi-variable biological system from the cellular, or subcellular, to the human or patient population level, wherein the biological system is controlled by a plurality of interrelated biologic processes defining functions occurring within the biological system, wherein said computer-implemented system includes one or more levels, each level comprising one or more distinct linkable entities representing biologic processes, and each level having a respective level of complexity, and a human interface for interacting with said one or more levels; and applying said interactive computer-implemented system to drug development, wherein said interactive computer-implemented system considers the effects of a drug on biologic processes to identify appropriate applications for the drug.
Claim 20
Independent Claim
127 words
A method for use in drug development, comprising the steps of: developing an interactive computer-implemented system for modelling a dynamic multi-variable biological system from the cellular, or subcellular, to the human or patient population level, wherein the biological system is controlled by a plurality of interrelated biologic processes defining functions occurring within the biological system, wherein said computer-implemented system includes one or more levels, each level comprising one or more distinct linkable entities representing biologic processes, and each level having a respective level of complexity, and a human interface for interacting with said one or more levels; and applying said interactive computer-implemented system to drug development, wherein said interactive computer-implemented system considers the effects of a drug on biologic processes to identify appropriate applications for the drug.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-08-11 | 2001-02-10 | 2001-08-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-08-11 | 2005-02-10 | 2005-08-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-08-11 | 2009-02-10 | 2009-08-12 | $7700.00 | Window Closed / Lapsed |