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US5643681A
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US
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Biocompatible coated article
Assignee: Cobe Cardiovascular Inc
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Filing: 1995-06-07
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Granted: 1997-07-01
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Expires: 2015-06-07
Abstract
Abstract The biocompatibility of polymeric and metallic articles used in contact with blood can be substantially improved by coating the articles as described. The coating materials are triblock copolymers of the polylactone-polysiloxane-polylactone type. Optimum biocompatibility is provided by a coating of optimum surface concentration. Porous membranes can be coated as described, providing improved biocompatibility of blood oxygenators, hemodialyzers and the like.
Inventors
- 👤 Marc Voorhees
- 👤 Lloyd Forrestal
- 👤 Harold Fisher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 14:15
CPC Classifications
B; B01; B01D; B01D67/00; B01D67/0081; B01D67/0088; A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; A61L31/00; A61L31/08; A61L31/10; A61L33/00; A61L33/06; A61L33/068; C; C09; C09D; C09D183/00; C09D183/10; Y; Y10; Y10T; Y10T428/00; Y10T428/249921; Y10T428/249953; Y10T428/249978; Y10T428/24998; Y10T428/249987; Y10T428/249991; Y10T428/249992; Y10T428/31504; Y10T428/31652; Y10T428/31663; Y10T428/31667; Y10T428/31678; Y10T428/31681; Y10T428/31786; Y10T428/31797
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
38 words
A polymeric article having a base polymer and a biocompatible coating thereon comprising a polylactone-polysiloxane-polylactone triblock copolymer, said coating having a relative surface concentration sufficient to provide an X-ray fluorescence intensity ratio in the range 0.1 to 0.25.
Claim 2
Dependent Claim
38 words
A polymeric article having a base polymer and a biocompatible coating thereon comprising a polylactone-polysiloxane-polylactone triblock copolymer, said coating having a relative surface concentration sufficient to provide an X-ray fluorescence intensity ratio in the range 0.1 to 0.25.
Claim 3
Dependent Claim
20 words
A polymeric article according to claim 1 wherein the X-ray fluorescence intensity ratio is in the range 0.14 to 0.22.
Claim 4
Dependent Claim
15 words
A polymeric article according to claim 1 wherein said base polymer is a polypropylene membrane.
Claim 5
Dependent Claim
15 words
A polymeric article according to claim 1 wherein said base polymer is a polyethylene membrane.
Claim 6
Dependent Claim
15 words
A polymeric article according to claim 1 wherein the triblock copolymer is a polycaprolactone-polysiloxane-polycaprolactone copolymer.
Claim 7
Dependent Claim
41 words
A polymeric article according to claim 5 wherein the triblock copolymer comprises polycaprolactone blocks having each a nominal molecular weight in the range 1000 to 10,000 and a polysiloxane block having a nominal molecular weight in the range 1000 to 5000.
Claim 8
Dependent Claim
34 words
A polymeric article according to claim 6 wherein the triblock copolymer comprises polycaprolactone blocks having a nominal molecular weight of 2000 and a polysiloxane block having a nominal molecular weight in the range 2000-3000.
Claim 9
Dependent Claim
38 words
A polymeric article having a base polymer and a biocompatible coating thereon comprising a polylactone-polysiloxane-polylactone triblock copolymer, said coating having a relative surface concentration sufficient to provide an X-ray fluorescence intensity ratio in the range 0.02 to 0.35.
Claim 10
Dependent Claim
38 words
A polymeric article having a base polymer and a biocompatible coating thereon comprising a polylactone-polysiloxane-polylactone triblock copolymer, said coating having a relative surface concentration sufficient to provide an X-ray fluorescence intensity ratio in the range 0.02 to 0.35.
Claim 11
Dependent Claim
20 words
A polymeric article according to claim 8 wherein the X-ray fluorescence intensity ratio is in the range 0.05 to 0.25.
Claim 12
Dependent Claim
20 words
A polymeric article according to claim 8 wherein the X-ray fluorescence intensity ratio is in the range 0.16 to 0.20.
Claim 13
Dependent Claim
15 words
A polymeric article according to claim 8 wherein said base polymer is a polypropylene membrane.
Claim 14
Dependent Claim
15 words
A polymeric article according to claim 8 wherein said base polymer is a polyethylene membrane.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-06-30 | 2000-12-30 | 2001-07-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-06-30 | 2004-12-30 | 2005-07-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-06-30 | 2008-12-30 | 2009-07-01 | $7700.00 | Window Closed / Lapsed |