Switched field magnetic resonance imaging

Claim 2

A magnetic resonance imaging method performed with a constant substantially homogeneous, static polarizing magnetic field B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged, said method comprising the steps of: (a) applying a switched further polarizing magnetic field to said nuclei during a time interval Δt 1 , which is less than the spin-lattice relaxation constant T1 NMR parameter of said nuclei, (b) performing an NMR pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time window for acquiring MRI data; and wherein step (a) occurs during occurrence of step (b) and wherein said further polarizing magnetic field opposes said static magnetic field B o .

Claim 3

A magnetic resonance imaging method as in claim 1 wherein step (b) includes an NMR spectroscopic imaging pulse sequence having at least one transmitted RF NMR pulse and wherein step (a) occurs only during transmission of said RF NMR pulse(s).

Claim 4

A magnetic resonance imaging method performed with a constant substantially homogeneous, static polarizing magnetic field B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged, said method comprising the steps of: (a) applying a switched further polarizing magnetic field to said nuclei during a time interval Δt 1 , which is less than the spin-lattice relaxation constant T1 NMR parameter of said nuclei, (b) performing an NMR pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time window for acquiring MRI data; and wherein said further polarizing magnetic field is oriented in the same direction as said static magnetic field B o and is applied during step (a) to moving nuclei outside an MRI image volume prior to step (b) so as to enhance their magnetization upon subsequent entry into the image volume.

Claim 5

A magnetic resonance imaging method performed with a constant substantially homogeneous, static polarizing magnetic field B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged, said method comprising the steps of: (a) applying a switched further polarizing magnetic field to said nuclei during a time interval Δt 1 , which is less than the spin-lattice relaxation constant T1 NMR parameter of said nuclei, (b) performing an NMR pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time window for acquiring MRI data; and wherein said further polarizing magnetic field is oriented in the same direction as said static magnetic field B o and is applied during step (a) to moving nuclei outside an MRI image volume prior to step (b) so as to enhance their magnetization upon subsequent entry into the image volume.

Claim 6

A magnetic resonance imaging method performed with a constant, substantially homogeneous, static polarizing magnetic field B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged, said method comprising the steps of: (a) applying a switched further polarizing magnetic field to said nuclei which opposes said static magnetic field B o ; (b) during Step (a) performing an NMR pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time for acquiring MRI data; and (c) repeating steps (a) and (b) during plural successive repetition intervals TR which include a period when said further polarizing magnetic field is not applied.

Claim 7

A magnetic resonance imaging method performed with a constant, substantially homogeneous, static polarizing magnetic field B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged, said method comprising the steps of: (a) applying a switched further polarizing magnetic field to said nuclei which opposes said static magnetic field B o ; (b) during Step (a) performing an NMR pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time for acquiring MRI data; and (c) repeating steps (a) and (b) during plural successive repetition intervals TR which include a period when said further polarizing magnetic field is not applied.

Claim 8

A magnetic resonance spectroscopic imaging method performed with a constant, substantially homogeneous, polarizing static magnetic field B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged, said method comprising the steps of: (a) performing an NMR spectroscopic pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time for acquiring MRSI data during each of plural successive repetition intervals TR; and (b) during application of said RF NMR nutation pulse(s) applying a switched further polarizing magnetic field to said nuclei which opposes said static magnetic field B o thereby reducing required RF transmission power and frequency.

Claim 9

A magnetic resonance spectroscopic imaging method performed with a constant, substantially homogeneous, polarizing static magnetic field B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged, said method comprising the steps of: (a) performing an NMR spectroscopic pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time for acquiring MRSI data during each of plural successive repetition intervals TR; and (b) during application of said RF NMR nutation pulse(s) applying a switched further polarizing magnetic field to said nuclei which opposes said static magnetic field B o thereby reducing required RF transmission power and frequency.

Claim 10

A magnetic resonance imaging method performed with a constant, substantially homogeneous, static polarizing magnetic field B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged within an image volume, said method comprising the steps of: (a) applying a switched further polarizing magnetic field to nuclei outside said image volume which is in the same sense as said static polarizing magnetic field B o ; (b) after step (a), performing an NMR pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time for acquiring MRI data; and (c) repeating steps (a) and (b) during plural successive repetition intervals TR to acquire a set of related MRI data.

Claim 11

A magnetic resonance imaging method performed with a constant, substantially homogeneous, static polarizing magnetic field B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged within an image volume, said method comprising the steps of: (a) applying a switched further polarizing magnetic field to nuclei outside said image volume which is in the same sense as said static polarizing magnetic field B o ; (b) after step (a), performing an NMR pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time for acquiring MRI data; and (c) repeating steps (a) and (b) during plural successive repetition intervals TR to acquire a set of related MRI data.

Claim 12

A magnetic resonance imaging method as in claim 6 further comprising, during step (a), also applying another switched polarizing magnetic field to nuclei inside said image volume in an opposite sense to said static polarizing magnetic field B o .

Claim 13

A magnetic resonance imaging apparatus having a constant substantially homogeneous, static polarizing magnetic field B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged, said apparatus comprising: (a) means for applying a switched further polarizing magnetic field to said nuclei during a time interval Δt 1 , which is less than the spin-lattice relaxation constant T1 NMR parameter of said nuclei, (b) means for performing an NMR pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time window for acquiring MRI data; and wherein said further polarizing magnetic field is oriented in the same direction as said static polarizing magnetic field B o and is applied to moving nuclei outside an MRI image volume to as to enhance their magnetization upon subsequent entry into the image volume.

Claim 14

A magnetic resonance imaging apparatus having a constant substantially homogeneous, static polarizing magnetic field B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged, said apparatus comprising: (a) means for applying a switched further polarizing magnetic field to said nuclei during a time interval Δt 1 , which is less than the spin-lattice relaxation constant T1 NMR parameter of said nuclei, (b) means for performing an NMR pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time window for acquiring MRI data; and wherein said further polarizing magnetic field is oriented in the same direction as said static polarizing magnetic field B o and is applied to moving nuclei outside an MRI image volume to as to enhance their magnetization upon subsequent entry into the image volume.

Claim 15

A magnetic resonance imaging apparatus as in claim 8 wherein another polarizing magnetic field also is applied, inside the image volume and in opposition to said static polarizing magnetic field B o .

Claim 16

A magnetic resonance imaging apparatus having a constant, substantially homogeneous, static polarizing magnetic field B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged, said apparatus comprising: (A) means for applying a switched further polarizing magnetic field to said nuclei which opposes said static polarizing magnetic field B o ; (B) means for performing an NMR pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time for acquiring MRI data; and (C) means for repetitively operating means (a) and (b) during plural successive repetition intervals TR which includes a sample preparation period when said further magnetic field is not applied.

Claim 17

A magnetic resonance imaging apparatus having a constant, substantially homogeneous, static polarizing magnetic field B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged, said apparatus comprising: (A) means for applying a switched further polarizing magnetic field to said nuclei which opposes said static polarizing magnetic field B o ; (B) means for performing an NMR pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time for acquiring MRI data; and (C) means for repetitively operating means (a) and (b) during plural successive repetition intervals TR which includes a sample preparation period when said further magnetic field is not applied.

Claim 18

A magnetic resonance spectroscopic imaging apparatus having a constant, substantially homogeneous, static polarizing magnetic field, B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged, said apparatus comprising: (a) means for performing an NMR spectroscopic pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time for acquiring MRSI data during each of plural successive repetition intervals TR; and (b) means for, during application of said RF NMR nutation pulse(s), applying a switched further polarizing magnetic field to said nuclei which opposes said static polarizing magnetic field B o thereby reducing required RF transmission power and frequency.

Claim 19

A magnetic resonance spectroscopic imaging apparatus having a constant, substantially homogeneous, static polarizing magnetic field, B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged, said apparatus comprising: (a) means for performing an NMR spectroscopic pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time for acquiring MRSI data during each of plural successive repetition intervals TR; and (b) means for, during application of said RF NMR nutation pulse(s), applying a switched further polarizing magnetic field to said nuclei which opposes said static polarizing magnetic field B o thereby reducing required RF transmission power and frequency.

Claim 20

A magnetic resonance imaging apparatus having a constant, substantially homogeneous, static polarizing magnetic field to B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged within an image volume, said apparatus comprising: (a) means for selectively applying a switched further polarizing magnetic field to nuclei outside said image volume which is in the same sense as said static polarizing magnetic field B o ; (b) means for performing an NMR pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time for acquiring MRI data; and (c) means for repetitively operating means (a) and (b) during plural successive repetition intervals TR to acquire a set of related MRI data.

Claim 21

A magnetic resonance imaging apparatus having a constant, substantially homogeneous, static polarizing magnetic field to B o generator and a plurality of pulsed gradient magnetic field G x , G y , G z generators applied to nuclei to be imaged within an image volume, said apparatus comprising: (a) means for selectively applying a switched further polarizing magnetic field to nuclei outside said image volume which is in the same sense as said static polarizing magnetic field B o ; (b) means for performing an NMR pulse sequence including application of at least one RF NMR nutation pulse and a responsive RF NMR signal reception time for acquiring MRI data; and (c) means for repetitively operating means (a) and (b) during plural successive repetition intervals TR to acquire a set of related MRI data.

Claim 22

A magnetic resonance imaging apparatus as in claim 12 further comprising, also applying another switched polarizing magnetic field to nuclei inside said image volume in an opposite sense to said static polarizing magnetic field B o .