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US5621093A
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Steam-sterilizing solid hyaluronic acid
Assignee: Anika Therapeutics Inc
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Filing: 1995-06-06
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Granted: 1997-04-15
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Expires: 2015-06-06
Abstract
Abstract A method for sterilizing solid hyaluronic acid includes autoclaving solid hyaluronic acid, whereby the solid hyaluronic acid is exposed to saturated steam at positive gauge pressure for a period of time that is sufficient to sterilize the solid hyaluronic acid. In one embodiment, autoclaving includes exposing the solid hyaluronic acid to saturated steam at a gauge pressure of about one atmosphere for a period of time between about fifteen and thirty minutes.
Inventors
- 👤 David A. Swann
- 👤 Jing-wen Kuo
- 👤 Vladimir Pinsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 12:05
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0072
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
16 words
A method for sterilizing solid hyaluronic acid, comprising the step of steam-sterilizing the solid hyaluronic acid.
Claim 2
Independent Claim
16 words
A method for sterilizing solid hyaluronic acid, comprising the step of steam-sterilizing the solid hyaluronic acid.
Claim 3
Dependent Claim
34 words
The method of claim 1, wherein said steam-sterilizing includes exposing the solid hyaluronic acid to saturated steam at a temperature of at least about 126° C. and a gauge pressure of about one atmosphere.
Claim 4
Dependent Claim
23 words
The method of claim 2, wherein said solid hyaluronic acid is steam-sterilized for a period of time of at least about fifteen minutes.
Claim 5
Dependent Claim
24 words
The method of claim 3, further including the step of precipitating said solid hyaluronic acid from a solution prior to steam-sterilizing the hyaluronic acid.
Claim 6
Dependent Claim
20 words
The method of claim 4, wherein the solid hyaluronic acid is precipitated from solution by adding ethanol to said solution.
Claim 7
Dependent Claim
22 words
The method of claim 5, further including the step of drying the precipitated solid hyaluronic acid prior to steam-sterilizing said hyaluronic acid.
Claim 8
Dependent Claim
45 words
The method of claim 1, wherein said steam-sterilizing includes exposing the solid hyaluronic acid to saturated steam at a temperature of at least about 121° C. and a gauge pressure of about one atmosphere for a period of time of at least about fifteen minutes.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-04-14 | 2000-10-14 | 2001-04-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-04-14 | 2004-10-14 | 2005-04-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-04-14 | 2008-10-14 | 2009-04-15 | $7700.00 | Window Closed / Lapsed |