US5619984A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dry powder inhalation device having a powder-loaded elongate carrier
Assignee: DMK Pharmaceuticals Corp
•
Filing: 1995-05-08
•
Granted: 1997-04-15
•
Expires: 2015-05-08
Abstract
Abstract A dry powder inhalation device comprising a housing defining a chamber in communication with a patient port in the form of a mouthpiece or nasal adaptor, and an elongate carrier bearing a powdered medicament, the device being constructed and arranged such that areas of predetermined size of the elongate carrier may sequentially be exposed within the chamber, the device comprising one or more air inlets such that when a patient inhales through the patient port an air flow is established from the air inlet(s) to the patient port through the chamber such that particles of the powdered medicament of respirable size from said exposed area of the elongate carrier are entrained within the air flow.
Inventors
- 👤 Peter D. Hodson
- 👤 David K. Smith
- 👤 David J. Velasquez
- 👤 Anthony C. L. Wass
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 10:39
CPC Classifications
A; A61; A61M; A61M15/00; A61M15/0028; A61M15/0045; A61M15/0001; A61M15/0005; A61M15/0006; A61M15/0013; A61M15/0016; A61M15/0021; A61M15/0025; A61M15/003; A61M15/0043; A61M15/0046; A61M15/0048; A61M15/0051; A61M15/0053; A61M15/0055; A61M15/0065; A61M15/0066; A61M15/0068; A61M15/0081; A61M15/0091; A61M15/0093; A61P; A61P11/00; A61M15/007; A61M15/0071; A61M15/0078; A61M15/0085; A61M15/02; A61M16/00; A61M16/0003; A61M2016/0015; A61M2016/0018; A61M2016/0024; A61M2202/00; A61M2202/06; A61M2202/064; A61M2205/00; A61M2205/82; A61M2205/8206
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
181 words
A dry powder inhalation device comprising: a housing defining a chamber, a patient port in communication with said chamber, and one or more air inlets in communication with said chamber so that when a patient inhales through said patient port an air flow is established from the air inlets to the patient port through the chamber; an elongate carrier disposed within said housing, preloaded with a plurality of doses of medicament, said medicament being in the form of a plurality of finely divided powder particles having a particle size in the range of from 1 to 10 μm, said finely divided powder particles being releasably retained directly on a surface of the carrier, without the presence of an adhesive between the carrier and powder particles by an attractive force between said carrier and said powder; and an advancement mechanism for exposing an area of predetermined size of the elongate carrier within the chamber so that the powder particles in said area are exposed to said air flow during inhalation and can be released from said carrier and entrained into said airflow.
Claim 2
Dependent Claim
181 words
A dry powder inhalation device comprising: a housing defining a chamber, a patient port in communication with said chamber, and one or more air inlets in communication with said chamber so that when a patient inhales through said patient port an air flow is established from the air inlets to the patient port through the chamber; an elongate carrier disposed within said housing, preloaded with a plurality of doses of medicament, said medicament being in the form of a plurality of finely divided powder particles having a particle size in the range of from 1 to 10 μm, said finely divided powder particles being releasably retained directly on a surface of the carrier, without the presence of an adhesive between the carrier and powder particles by an attractive force between said carrier and said powder; and an advancement mechanism for exposing an area of predetermined size of the elongate carrier within the chamber so that the powder particles in said area are exposed to said air flow during inhalation and can be released from said carrier and entrained into said airflow.
Claim 3
Dependent Claim
24 words
The device of claim 1 further comprising a mechanism for applying a force to said carrier to release said powder particles from said carrier.
Claim 4
Dependent Claim
30 words
The device of claim 2 wherein said mechanism for applying a force is adapted to apply an electrical, piezoelectrical, electromagnetic or mechanical force to the carrier to vibrate the carrier.
Claim 5
Dependent Claim
24 words
The device of claim 3 wherein said mechanism for applying a force produces vibrations in the frequency range of from 5 to 50,000 Hz.
Claim 6
Dependent Claim
26 words
The device of claim 2 wherein said mechanism for applying a force comprises a member positioned to impact or strike the exposed area of the carrier.
Claim 7
Dependent Claim
21 words
The device of claim 2 wherein said mechanism for applying a force releases said powder by applying tension to said carrier.
Claim 8
Dependent Claim
29 words
The device of claim 2 wherein said mechanism for applying a force releases said powder by suddenly stopping said carrier while it is being advanced by said advancement mechanism.
Claim 9
Dependent Claim
26 words
The device of claim 2 wherein said mechanism for applying a force comprises a member positioned to scrape or brush said exposed portion of said carrier.
Claim 10
Dependent Claim
35 words
The device of claim 3 wherein said mechanism for applying a force comprises a source of compressed or liquified gas positioned to direct a flow of said gas against said exposed portion of said carrier.
Claim 11
Dependent Claim
19 words
The device of claim 2 wherein said mechanism for applying a force is actuated by inhalation by a patient.
Claim 12
Dependent Claim
37 words
The device of claim 10 further comprising a moveable vane positioned to be moved, by air flow during inhalation, from a first position to a second position in which it actuates said mechanism for applying a force.
Claim 13
Dependent Claim
37 words
The device of claim 11 wherein said moveable vane comprises a one-way valve positioned to allow passage of air from the chamber to the patient port while blocking air flow from the patient port to the chamber.
Claim 14
Dependent Claim
19 words
The device of claim 1 further comprising a tensioning element for holding said exposed portion of said carrier taut.
Claim 15
Dependent Claim
72 words
The device of claim 1 wherein said elongate carrier is provided in the form of a tape or web which is wound on a first spool and said advancement mechanism comprises a rotatable take-up spool which receives an end of said carrier and which is positioned so that rotation of the take-up spool causes a portion of the carrier to be unwound from the first spool and wound onto the take-up spool.
Claim 16
Dependent Claim
20 words
The device of claim 1 further comprising an actuator adapted to actuate the advancement mechanism after inhalation by a patient.
Claim 17
Dependent Claim
173 words
A dry powder inhalation device comprising: a housing defining a chamber, a patient port in communication with said chamber, and one or more air inlets in communication with said chamber so that when a patient inhales through said patient port an air flow is established from the air inlets to the patient port through the chamber; an elongate carrier disposed within said housing, having a planar surface comprising a plurality of microdepressions extending below said planar surface, said elongate carrier being preloaded with a plurality of doses of medicament, said medicament being in the form of a plurality of finely divided powder particles having a particle size in the range of from 1 to 10 μm, said finely divided powder particles being releasably retained within said microdepressions; and an advancement mechanism for exposing an area of predetermined size of the elongate carrier within the chamber so that the powder particles in said area are exposed to said air flow during inhalation and can be released from said carrier and entrained into said airflow.
Claim 18
Dependent Claim
173 words
A dry powder inhalation device comprising: a housing defining a chamber, a patient port in communication with said chamber, and one or more air inlets in communication with said chamber so that when a patient inhales through said patient port an air flow is established from the air inlets to the patient port through the chamber; an elongate carrier disposed within said housing, having a planar surface comprising a plurality of microdepressions extending below said planar surface, said elongate carrier being preloaded with a plurality of doses of medicament, said medicament being in the form of a plurality of finely divided powder particles having a particle size in the range of from 1 to 10 μm, said finely divided powder particles being releasably retained within said microdepressions; and an advancement mechanism for exposing an area of predetermined size of the elongate carrier within the chamber so that the powder particles in said area are exposed to said air flow during inhalation and can be released from said carrier and entrained into said airflow.
Claim 19
Dependent Claim
21 words
The dry powder inhalation device of claim 16 wherein said microdepressions are selected from the group consisting of microgrooves and microdimples.
Claim 20
Dependent Claim
37 words
The dry powder inhaler of claim 16 further comprising an impactor positioned to strike a surface of said elongate carrier opposite said planar surface to cause said carrier to release said powder particles in said exposed area.
Claim 21
Dependent Claim
211 words
A dry powder inhalation device comprising: a housing defining a chamber, a patient port in communication with said chamber, and one or more air inlets in communication with said chamber so that when a patient inhales through said patient port an air flow is established from the air inlets to the patient port through the chamber; an elongate carrier disposed within said housing, said elongate carrier being preloaded with a plurality of doses of medicament, said medicament being in the form of a plurality of finely divided powder particles having a particle size in the range of from 1 to 10 μm, said finely divided powder particles being releasably retained directly on a powder-carrying surface of said elongate carrier without a protective capsule or coating surrounding the particles; an advancement mechanism for exposing an area of predetermined size of the elongate carrier within the chamber so that the powder particles in said area are exposed to said air flow during inhalation and can be released from said carrier and entrained into said airflow; and a release mechanism for releasing said powder particles from said elongate carrier by applying a force to said elongate carrier, said release mechanism being positioned to avoid direct contact with said powder-carrying surface and said powder particles.
Claim 22
Dependent Claim
211 words
A dry powder inhalation device comprising: a housing defining a chamber, a patient port in communication with said chamber, and one or more air inlets in communication with said chamber so that when a patient inhales through said patient port an air flow is established from the air inlets to the patient port through the chamber; an elongate carrier disposed within said housing, said elongate carrier being preloaded with a plurality of doses of medicament, said medicament being in the form of a plurality of finely divided powder particles having a particle size in the range of from 1 to 10 μm, said finely divided powder particles being releasably retained directly on a powder-carrying surface of said elongate carrier without a protective capsule or coating surrounding the particles; an advancement mechanism for exposing an area of predetermined size of the elongate carrier within the chamber so that the powder particles in said area are exposed to said air flow during inhalation and can be released from said carrier and entrained into said airflow; and a release mechanism for releasing said powder particles from said elongate carrier by applying a force to said elongate carrier, said release mechanism being positioned to avoid direct contact with said powder-carrying surface and said powder particles.
Claim 23
Dependent Claim
28 words
The dry powder inhalation device of claim 19 wherein said release mechanism comprises an impactor positioned to impact a surface of said elongate carrier opposite said powder-carrying surface.
Claim 24
Dependent Claim
211 words
A dry powder inhalation device comprising: a housing defining a chamber, a patient port in communication with said chamber, and one or more air inlets in communication with said chamber so that when a patient inhales through said patient port an air flow is established from the air inlets to the patient port through the chamber; an elongate carrier disposed within said housing, said elongate carrier being preloaded with a plurality of doses of medicament, said medicament being in the form of a plurality of finely divided powder particles having a particle size in the range of from 1 to 10 μm, said finely divided powder particles being releasably retained on a powder-carrying surface of said elongate carrier; an advancement mechanism for exposing an area of predetermined size of the elongate carrier within the chamber so that the powder particles in said area are exposed to said air flow during inhalation and can be released from said carrier and entrained into said airflow; and a release mechanism for releasing said powder particles from said elongate carrier by applying a force to said elongate carrier, said release mechanism comprising an impactor positioned to strike a surface opposite said powder-carrying surface to avoid direct contact with said powder-carrying surface and said powder particles.
Claim 25
Dependent Claim
211 words
A dry powder inhalation device comprising: a housing defining a chamber, a patient port in communication with said chamber, and one or more air inlets in communication with said chamber so that when a patient inhales through said patient port an air flow is established from the air inlets to the patient port through the chamber; an elongate carrier disposed within said housing, said elongate carrier being preloaded with a plurality of doses of medicament, said medicament being in the form of a plurality of finely divided powder particles having a particle size in the range of from 1 to 10 μm, said finely divided powder particles being releasably retained on a powder-carrying surface of said elongate carrier; an advancement mechanism for exposing an area of predetermined size of the elongate carrier within the chamber so that the powder particles in said area are exposed to said air flow during inhalation and can be released from said carrier and entrained into said airflow; and a release mechanism for releasing said powder particles from said elongate carrier by applying a force to said elongate carrier, said release mechanism comprising an impactor positioned to strike a surface opposite said powder-carrying surface to avoid direct contact with said powder-carrying surface and said powder particles.
References Cited (Backward Citations)
DE25422C
Cited
GB1479283A
Cited
DE2346730B2
Cited
US3971377A
Cited
US3948264A
Cited
US4147166A
Cited
DE2837040A1
Cited
GB2061735A
Cited
EP0042468A1
Cited
GB2144997A
Cited
EP0069715A1
Cited
GB2102295A
Cited
GB2108390A
Cited
EP0079478A1
Cited
FR2516387A1
Cited
GB2166957A
Cited
GB2122903A
Cited
SE432054B
Cited
WO1985001880A1
Cited
EP0166294A2
Cited
GB2162152A
Cited
EP0224335A2
Cited
EP0239802A2
Cited
US4735358A
Cited
US5204113A
Cited
US5019974A
Cited
DE8806288U1
Cited
EP0342859A2
Cited
GB2218831A
Cited
US4984158A
Cited
US5153827A
Cited
WO1990013328A1
Cited
EP0403294A1
Cited
US5036462A
Cited
EP0469814A1
Cited
WO1992005824A1
Cited
WO1992015353A2
Cited
WO1993000951A1
Cited
EP0526166A2
Cited
WO1993012823A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-04-14 | 2000-10-14 | 2001-04-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-04-14 | 2004-10-14 | 2005-04-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-04-14 | 2008-10-14 | 2009-04-15 | $7700.00 | Window Closed / Lapsed |