US5617860A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and system for producing polarized 129 Xe gas
Assignee: Smithsonian Astrophysical Observatory
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Filing: 1995-06-07
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Granted: 1997-04-08
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Expires: 2015-06-07
Abstract
Abstract A method and system for producing polarized 129Xe gas in an economical manner, allowing the polarized 129Xe gas to be used commercially in research and clinical applications. The production system of the present invention includes a holding tank for holding an unpolarized xenon gas/nitrogen gas mixture. The holding tank is in communication with a temperature controlled polarization chamber. A wide spectrum high power light source such as a diode laser array is in communication with the polarization chamber. The alkali metal vapor is optically pumped by the light source. The polarization chamber, which contains a given quantity of an alkali metal and its associated vapor, receives the gaseous mixture from the holding tank. The optically pumped alkali metal vapor atoms then collide with the xenon gas atoms, thus polarizing the xenon atoms. The entire gaseous mixture expands out of the polarization chamber into a device that separates the alkali metal vapor atoms from the polarized 129Xe atoms. The polarized 129Xe atoms are then controllably output to a system/user interface for application purposes.
Inventors
- 👤 Timothy Chupp
- 👤 Kevin P. Coulter
- 👤 Eduardo Oteiza
- 👤 Ronald Walsworth
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 00:23
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/18; A61K49/1806; A61K49/1815; C; C01; C01B; C01B23/00
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
102 words
A system for producing polarized xenon-129 gas, comprising: a storage tank containing a quantity of non-polarized xenon-129 gas; a polarization chamber for controllably receiving a quantity of said non-polarized xenon-129 gas from said storage tank, said polarization chamber containing a predetermined quantity of alkali metal having an associated alkali metal vapor; a tunable broadband light source positioned relative to said polarization chamber for optically pumping said alkali metal vapor, said optically pumped metal vapor causing collisional polarization of said xenon-129 gas; and means for separating said alkali metal vapor from said polarized xenon-129 gas subsequent to said polarization of said xenon-129 gas.
Claim 2
Independent Claim
102 words
A system for producing polarized xenon-129 gas, comprising: a storage tank containing a quantity of non-polarized xenon-129 gas; a polarization chamber for controllably receiving a quantity of said non-polarized xenon-129 gas from said storage tank, said polarization chamber containing a predetermined quantity of alkali metal having an associated alkali metal vapor; a tunable broadband light source positioned relative to said polarization chamber for optically pumping said alkali metal vapor, said optically pumped metal vapor causing collisional polarization of said xenon-129 gas; and means for separating said alkali metal vapor from said polarized xenon-129 gas subsequent to said polarization of said xenon-129 gas.
Claim 3
Dependent Claim
34 words
The system of claim 1, further comprising temperature controlling means for said polarization chamber for regulating temeprature, and therefore density, of said alkali metal vapor for optimizing collisional polarization of said non-polarized xenon-129 gas.
Claim 4
Dependent Claim
16 words
The system of claim 1, wherein said tunable broadband light source is a diode laser array.
Claim 5
Dependent Claim
11 words
The system of claim 1, wherein said alkali metal is rubidium.
Claim 6
Dependent Claim
34 words
The system of claim 1, wherein said polarization chamber is located in a magnetic field having a strength and spatial homogeneity sufficient for magnetic gradient induced depolarization of the xenon-129 atoms to be insignificant.
Claim 7
Dependent Claim
69 words
The system of claim 5, further comprising a magnetic resonance imaging machine for producing said magnetic field wherein said light from said tunable broadband light source is projected along a direction of the magnetic field and through the polarization chamber, said light being resonant with an alkali atomic transition that induces an electron spin polarization in said alkali metal vapor collinear to the magnetic field via said optical pumping.
Claim 8
Dependent Claim
28 words
The system of claim 1, wherein said non-polarized xenon gas includes a buffer gas to broaden a rubidium absorption line to increase efficiency of said broadband light source.
Claim 9
Dependent Claim
11 words
The system of claim 7, wherein said buffer gas is nitrogen.
Claim 10
Dependent Claim
26 words
The system of claim 1, further comprising an input valve wherein said non-polarized xenon-129 gas is controllably input into said polarization chamber through said input valve.
Claim 11
Independent Claim
132 words
A method of producing polarized xenon-129 gas, comprising the steps of: providing a polarization chamber; introducing a quantity of an alkali metal into said chamber, said alkali metal having an associated alkali metal vapor; controlling the temperature of said polarization chamber to maintain said alkali metal vapor density at a predetermined level; optically pumping said alkali metal vapor with a tunable broadband light source to polarize said alkali metal vapor atoms; introducing a predetermined quantity of non-polarized xenon gas into said chamber containing said alkali metal, said non-polarized xenon-129 gas including a buffer gas; transferring polarization of said alkali metal vapor atoms to said non-polarized xenon-129 atoms; and causing said gaseous mixture in said polarization chamber to expand into means for separating said alkali metal vapor atoms from said polarized xenon-129 atoms.
Claim 12
Independent Claim
132 words
A method of producing polarized xenon-129 gas, comprising the steps of: providing a polarization chamber; introducing a quantity of an alkali metal into said chamber, said alkali metal having an associated alkali metal vapor; controlling the temperature of said polarization chamber to maintain said alkali metal vapor density at a predetermined level; optically pumping said alkali metal vapor with a tunable broadband light source to polarize said alkali metal vapor atoms; introducing a predetermined quantity of non-polarized xenon gas into said chamber containing said alkali metal, said non-polarized xenon-129 gas including a buffer gas; transferring polarization of said alkali metal vapor atoms to said non-polarized xenon-129 atoms; and causing said gaseous mixture in said polarization chamber to expand into means for separating said alkali metal vapor atoms from said polarized xenon-129 atoms.
Claim 13
Dependent Claim
38 words
The method of claim 10, further comprising the step of projecting light from said light source used for optically pumping said alkali metal vapor in a direction along a magnetic field generated by a magnetic resonance imaging machine.
Claim 14
Independent Claim
149 words
A method of delivering a quantity of polarized xenon-129 gas, comprising the steps of: providing a polarization chamber; introducing a quantity of an alkali metal into said chamber, said alkali metal having an associated alkali metal vapor; controlling the temperature of said polarization chamber to maintain said alkali metal vapor density at a predetermined level; optically pumping said alkali metal vapor with a tunable broadband light source to polarize said alkali metal vapor atoms; introducing a predetermined quantity of non-polarized xenon-129 gas into said chamber containing said alkali metal, said non-polarized xenon-129 gas including a buffer gas; transferring polarization of said alkali metal vapor atoms to said non-polarized xenon-129 atoms; supplying said separated, polarized xenon-129 gas to a system/patient interface; separating the polarized xenon-129 gas from the alkali metal vapor; and causing said polarized xenon-129 gas to be ingested by a patient through said interface for magnetic resonance imaging.
Claim 15
Independent Claim
149 words
A method of delivering a quantity of polarized xenon-129 gas, comprising the steps of: providing a polarization chamber; introducing a quantity of an alkali metal into said chamber, said alkali metal having an associated alkali metal vapor; controlling the temperature of said polarization chamber to maintain said alkali metal vapor density at a predetermined level; optically pumping said alkali metal vapor with a tunable broadband light source to polarize said alkali metal vapor atoms; introducing a predetermined quantity of non-polarized xenon-129 gas into said chamber containing said alkali metal, said non-polarized xenon-129 gas including a buffer gas; transferring polarization of said alkali metal vapor atoms to said non-polarized xenon-129 atoms; supplying said separated, polarized xenon-129 gas to a system/patient interface; separating the polarized xenon-129 gas from the alkali metal vapor; and causing said polarized xenon-129 gas to be ingested by a patient through said interface for magnetic resonance imaging.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-04-07 | 2000-10-07 | 2001-04-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-04-07 | 2004-10-07 | 2005-04-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-04-07 | 2008-10-07 | 2009-04-08 | $7700.00 | Window Closed / Lapsed |