US5616689A
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US
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Method of controlling structure stability of collagen fibers produced form solutions or dispersions treated with sodium hydroxide for infectious agent deactivation
Assignee: Angiotech Pharmaceuticals Inc
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Filing: 1994-07-13
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Granted: 1997-04-01
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Expires: 2014-07-13
Abstract
Abstract In accordance with the present invention, stabilized dispersions of collagen fibers that have been treated in order to inactivate infectious agents and methods of stabilizing such collagen fibers are provided.
Inventors
- 👤 Vivek N. Shenoy
- 👤 Timothy T. Revak
- 👤 George H. Chu
- 👤 Hugh R. McMullin
- 👤 Joel S. Rosenblatt
- 👤 George R. Martin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 15:59
CPC Classifications
D; D01; D01F; D01F4/00; A; A01; A01N; A01N1/00; A61; A61L; A61L2/00; A61L2/16; A61L2/18; C; C08; C08H; C08H1/00; C08H1/06; C08L; C08L89/00; C08L89/04; C08L89/06; A61L2103/00; A61L2103/05
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
74 words
An improved dispersion of collagen fibers prepared from a solution or a dispersion of collagen, said collagen having been treated with a sodium hydroxide to inactivate infectious agents and said collagen fibers having been destabilized as a result of treatment with said sodium hydroxide, wherein the improvement comprises said collagen fibers having been stabilized by a physical fiber-stabilizing agent, said agent comprising a polymeric material capable of causing collagen fibers to precipitate from solution.
Claim 2
Dependent Claim
74 words
An improved dispersion of collagen fibers prepared from a solution or a dispersion of collagen, said collagen having been treated with a sodium hydroxide to inactivate infectious agents and said collagen fibers having been destabilized as a result of treatment with said sodium hydroxide, wherein the improvement comprises said collagen fibers having been stabilized by a physical fiber-stabilizing agent, said agent comprising a polymeric material capable of causing collagen fibers to precipitate from solution.
Claim 3
Dependent Claim
19 words
The dispersion of stabilized collagen fibers of claim 1, wherein said polymeric material is water soluble or water miscible.
Claim 4
Dependent Claim
57 words
The dispersion of stabilized collagen fibers of claim 2, wherein said water soluble or water miscible polymeric material is selected from the group consisting of: polyvinyl alcohol, polyethylene oxide, polyvinylpyrrolidone, polyacrylamide, polyethylene glycol, polypropylene glycol, polyvinyl methyl ether, maleic anhydride copolymers, hydroxyethyl starches, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, agarose, dextrins, dextrans, pectins and alginates.
Claim 5
Dependent Claim
20 words
The dispersion of stabilized collagen fibers of claim 2, wherein said water soluble or water miscible polymeric material is biocompatible.
Claim 6
Dependent Claim
30 words
The dispersion of stabilized collagen fibers of claim 4, wherein said water soluble or water miscible polymeric material is selected from the group consisting of polyethylene glycols and derivatives thereof.
Claim 7
Dependent Claim
33 words
The dispersion of stabilized collagen fibers of claim 5, wherein said water soluble or water miscible polymeric material is a polyethylene glycol having a molecular weight ranging from about 200 to about 20,000.
Claim 8
Dependent Claim
24 words
The dispersion of stabilized collagen fibers of claim 6, wherein said polyethylene glycol has a molecular weight ranging from about 200 to about 8,000.
Claim 9
Dependent Claim
88 words
An improved dispersion of collagen fibers prepared from a solution or a dispersion of collagen, said collagen having been treated with a sodium hydroxide to inactivate infectious agents and said collagen fibers having been destabilized as a result of treatment with said sodium hydroxide wherein the improvement comprises said collagen fibers having been stabilized by a chemical fiber-stabilizing agent, wherein said agent comprises a crosslinker reacted with said collagen fiber either prior to or subsequent to the treatment of said collagen solution or dispersion by said sodium hydroxide.
Claim 10
Dependent Claim
88 words
An improved dispersion of collagen fibers prepared from a solution or a dispersion of collagen, said collagen having been treated with a sodium hydroxide to inactivate infectious agents and said collagen fibers having been destabilized as a result of treatment with said sodium hydroxide wherein the improvement comprises said collagen fibers having been stabilized by a chemical fiber-stabilizing agent, wherein said agent comprises a crosslinker reacted with said collagen fiber either prior to or subsequent to the treatment of said collagen solution or dispersion by said sodium hydroxide.
Claim 11
Dependent Claim
23 words
The dispersion of claim 8, wherein said crosslinker is reacted with said collagen fibers subsequent to the treatment of said solution or dispersion.
Claim 12
Dependent Claim
32 words
The dispersion of stabilized collagen fibers of claim 8 or claim 9, wherein said crosslinker is selected from the group consisting of glutaraldehyde, hexamethyl diisocyanate, dimethyl suberimidate, carbodiimide and activated polyethylene glycol.
Claim 13
Dependent Claim
17 words
The dispersion of stabilized collagen fibers of claim 8 or claim 9, wherein said crosslinker is biocompatible.
Claim 14
Dependent Claim
18 words
The dispersion of stabilized collagen fibers of claim 11, wherein said biocompatible crosslinker is an activated polyethylene glycol.
Claim 15
Dependent Claim
64 words
The dispersion of stabilized collagen fibers of claim 12, wherein said activated polyethylene glycol is selected from the group consisting of polyethylene glycol succinimidyl glutarate, polyethylene glycol succinimidyl, polyethylene glycol succinimidyl carbonate, polyethylene glycol propion aldehyde and polyethylene glycol glycidyl ether, wherein at least two active sites are present on each polyethylene glycol molecule prior to crosslinking with collagen fibers of said collagen dispersion.
Claim 16
Dependent Claim
85 words
In a method for preparing a dispersion of collagen fibers from a solution or a dispersion of collagen wherein said collagen has been treated with a sodium hydroxide to inactivate infectious agents and wherein said collagen fibers have been destabilized as a result of treatment with said sodium hydroxide, the improvement comprising stabilizing said collagen fibers subsequent to said treatment by reacting said collagen fibers with a physical fiber-stabilizing agent, said agent comprising a polymeric material capable of causing collagen fibers to precipitate from solution.
Claim 17
Dependent Claim
85 words
In a method for preparing a dispersion of collagen fibers from a solution or a dispersion of collagen wherein said collagen has been treated with a sodium hydroxide to inactivate infectious agents and wherein said collagen fibers have been destabilized as a result of treatment with said sodium hydroxide, the improvement comprising stabilizing said collagen fibers subsequent to said treatment by reacting said collagen fibers with a physical fiber-stabilizing agent, said agent comprising a polymeric material capable of causing collagen fibers to precipitate from solution.
Claim 18
Dependent Claim
15 words
The method of claim 14, wherein said polymeric material is water soluble or water miscible.
Claim 19
Dependent Claim
53 words
The method of claim 15, wherein said water soluble or water miscible polymeric material is selected from the group consisting of polyvinyl alcohol, polyethylene oxide, polyvinylpyrrolidone, polyacrylamide, polyethylene glycol, polypropylene glycol, polyvinyl methyl ether, maleic anhydride copolymers, hydroxyethyl starches, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, agarose, dextrins, dextrans, pectins and alginates.
Claim 20
Dependent Claim
16 words
The method of claim 15, wherein said water soluble or water miscible polymeric material is biocompatible.
Claim 21
Dependent Claim
22 words
The method of claim 17, wherein said biocompatible polymeric material is selected from the group consisting of polyethylene glycols and derivatives thereof.
Claim 22
Dependent Claim
29 words
The method of claim 18, wherein said water soluble or water miscible polymeric material is a polyethylene glycol having a molecular weight ranging from about 200 to about 20,000.
Claim 23
Dependent Claim
29 words
The method of claim 19, wherein said water soluble or water miscible polymeric material is a polyethylene glycol having a molecular weight ranging from about 1,000 to about 6,000.
Claim 24
Dependent Claim
37 words
The method of claim 20, wherein the concentration of said polyethylene glycol ranges from about 2.3 mg/ml to about 2.6 mg/ml and the concentration of said collagen fiber ranges from about 10 mg/ml to about 100 mg/ml.
Claim 25
Dependent Claim
35 words
The method of claim 21, wherein the concentration of polyethylene glycol ranges from about 2.3 mg/ml to about 2.6 mg/ml and the concentration of said collagen fiber ranges from about 10 to about 50 mg/ml.
Claim 26
Dependent Claim
86 words
In a method for preparing a dispersion of collagen fibers from a solution or a dispersion of collagen wherein said collagen has been treated with a sodium hydroxide to inactivate infectious agents and wherein said collagen fibers have been destabilized as a result of treatment with said sodium hydroxide, the improvement comprising crosslinking said collagen fibers by reacting said collagen fibers with a chemical fiber-stabilizing agent prior to or subsequent to said treatment with a sodium hydroxide of said solution or dispersion containing said collagen fibers.
Claim 27
Dependent Claim
86 words
In a method for preparing a dispersion of collagen fibers from a solution or a dispersion of collagen wherein said collagen has been treated with a sodium hydroxide to inactivate infectious agents and wherein said collagen fibers have been destabilized as a result of treatment with said sodium hydroxide, the improvement comprising crosslinking said collagen fibers by reacting said collagen fibers with a chemical fiber-stabilizing agent prior to or subsequent to said treatment with a sodium hydroxide of said solution or dispersion containing said collagen fibers.
Claim 28
Dependent Claim
16 words
The method of claim 23, wherein said crosslinking is accomplished using a biocompatible chemical fiber-stabilizing agent.
Claim 29
Dependent Claim
15 words
The method of claim 24 wherein said chemical fiber-stabilizing agent is an activated polyethylene glycol.
Claim 30
Dependent Claim
15 words
The method of claim 23, wherein said crosslinking is carried out subsequent to said treatment.
Claim 31
Dependent Claim
12 words
The method of claim 26, wherein said chemical fiber-stabilizing agent is glutaraldehyde.
Claim 32
Dependent Claim
23 words
The method of claim 27, wherein the concentration ratio of said glutaraldehyde to said collagen fiber ranges from about 0.0005:1 to about 0.02:1.
Claim 33
Dependent Claim
29 words
The method of claim 23 or claim 26, wherein said chemical fiber-stabilizing agent is selected from the group consisting of glutaraldehyde, hexamethyl diisocyanate, dimethyl suberimidate, carbodiimide and activated polyethyleneglycol.
References Cited (Backward Citations)
US2934446A
Cited
US3121049A
Cited
US3131130A
Cited
US3530037A
Cited
US4021522A
Cited
US4233360A
Cited
US4097234A
Cited
US4511653A
Cited
US4980403A
Cited
US5162430A
Cited
US5264214A
Cited
US5292802A
Cited
US5304595A
Cited
US5306500A
Cited
US5376375A
Cited
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