US5594336A — Three point technique using spin and gradient ech…

Claim 1

Independent Claim 217 words

In a magnetic resonance imaging method in which a resonance excitation pulse and a resonance refocusing pulse are applied to generate a spin echo and in which read gradients are reversed in order to induce gradient echoes in association with each spin echo, the improvement comprising: inducing the spin echo when resonance signals of a first and second species are substantially in-phase; and, generating the gradient echoes at a time when the resonance signals of the first and second species are substantially 180° out-of-phase such that an in-phase spin echo and out-of-phase gradient echoes are generated in each repetition of the imaging sequence; reconstructing a spin echo image from the spin echo signals from a plurality of repetitions of the imaging sequence; generating first and second gradient echo images from the gradient echo signals of the plurality of repetitions of the imaging sequence; generating a phase correction map from the spin echo image and the first and second gradient echo images; correcting phase error in the first gradient echo image in accordance with the phase map; additively combining the spin echo image with the phase corrected first gradient echo image to generate a first species image; and, subtractively combining the spin echo image with the phase corrected first gradient echo image to generate a second species image.

Claim 2

Dependent Claim 217 words

In a magnetic resonance imaging method in which a resonance excitation pulse and a resonance refocusing pulse are applied to generate a spin echo and in which read gradients are reversed in order to induce gradient echoes in association with each spin echo, the improvement comprising: inducing the spin echo when resonance signals of a first and second species are substantially in-phase; and, generating the gradient echoes at a time when the resonance signals of the first and second species are substantially 180° out-of-phase such that an in-phase spin echo and out-of-phase gradient echoes are generated in each repetition of the imaging sequence; reconstructing a spin echo image from the spin echo signals from a plurality of repetitions of the imaging sequence; generating first and second gradient echo images from the gradient echo signals of the plurality of repetitions of the imaging sequence; generating a phase correction map from the spin echo image and the first and second gradient echo images; correcting phase error in the first gradient echo image in accordance with the phase map; additively combining the spin echo image with the phase corrected first gradient echo image to generate a first species image; and, subtractively combining the spin echo image with the phase corrected first gradient echo image to generate a second species image.

Claim 3

Dependent Claim 60 words

In the magnetic resonance imaging method as set forth in claim 1, the improvement further comprising: generating a first of the gradient echoes a time π/δω before the spin echo, where δω is a difference in the resonance frequencies of the first and second species; and, generating second of the gradient echoes at a time π/δω after the spin echo.

Claim 4

Dependent Claim 81 words

In the magnetic resonance imaging method as set forth in claim 2, the improvement further comprising: generating the spin echo at a time when resonance signals of the first species, second species, and a third species are all in-phase; generating a third gradient echo at a time π/δω' after the spin echo, where δω' is a difference in the resonance frequencies between the first and third species; and, generating a fourth gradient echo at a time π/δω' before the spin echo.

Claim 5

Dependent Claim 27 words

In the magnetic resonance imaging method as set forth in claim 2, the improvement further comprising the first species being water and the second species being fat.

Claim 6

Dependent Claim 166 words

In a magnetic resonance imaging method in which a resonance excitation pulse and a resonance refocusing pulse are applied to generate a spin echo add in which read gradients are reversed in order to induce first and second gradient echoes in association with each spin echo, the improvement further comprising: inducing the spin echo when resonance signals of a first and second species are substantially in-phase; and, generating the gradient echoes at a time when the resonance signals of the first and second species are substantially 180° out-of-phase such that an in-phase spin echo and out-of-phase gradient echoes are generated in each repetition of the imaging sequence; applying an additional refocusing RF pulse after the spin echo and the first and second gradient echoes to induce a second spin echo at a time when the first and second species are again in-phase; and, generating a pair of additional gradient echoes after the second refocusing pulse at times when the first and second species are 180° out-of-phase.

Claim 7

Dependent Claim 166 words

In a magnetic resonance imaging method in which a resonance excitation pulse and a resonance refocusing pulse are applied to generate a spin echo add in which read gradients are reversed in order to induce first and second gradient echoes in association with each spin echo, the improvement further comprising: inducing the spin echo when resonance signals of a first and second species are substantially in-phase; and, generating the gradient echoes at a time when the resonance signals of the first and second species are substantially 180° out-of-phase such that an in-phase spin echo and out-of-phase gradient echoes are generated in each repetition of the imaging sequence; applying an additional refocusing RF pulse after the spin echo and the first and second gradient echoes to induce a second spin echo at a time when the first and second species are again in-phase; and, generating a pair of additional gradient echoes after the second refocusing pulse at times when the first and second species are 180° out-of-phase.

Claim 8

Independent Claim 297 words

A method of magnetic resonance imaging comprising: (a) disposing a subject in a temporally constant magnetic field; (b) applying a radio frequency excitation pulse to excite magnetic resonance in first and second species of dipoles in the subject, which first and second species have magnetic resonance frequencies which differ by a frequency difference δω; (c) applying a radio frequency refocusing pulse for inducing a spin echo a duration τ after the refocusing pulse; (d) applying a read gradient concurrently with the spin echo; (e) applying further gradient pulses of opposite polarity to induce at least first and second gradient echoes offset by times ±(2n+1)π/δω from the spin echo, where n is an integer, such that the first and second gradient echoes have phase components that are offset by 180° from the spin echo; (f) applying phase encode gradients such that the spin echo and the first and second gradient echoes have a common phase encoding; (g) repeating at least steps (b)-(f) with different phase encode gradients to generate a plurality of differently phase encoded spin echo resonance signals, first gradient echo resonance signals, and second gradient echo resonance signals; (h) reconstructing the spin echo, the first gradient echo, and the second gradient echo resonance signals into a spin echo image, a first gradient echo image, and a second gradient echo image; (i) generating a phase correction map from the spin echo and first and second gradient echo images; (j) correcting a phase of one of the gradient echo images with the phase map; (k) additively combining the phase corrected image with the spin echo image which is 180° out-of-phase therewith to generate a first species image; and, (l) subtractively combining the phase corrected image with the 180° out-of-phase spin echo image to generate a second species image.

Claim 9

Independent Claim 297 words

A method of magnetic resonance imaging comprising: (a) disposing a subject in a temporally constant magnetic field; (b) applying a radio frequency excitation pulse to excite magnetic resonance in first and second species of dipoles in the subject, which first and second species have magnetic resonance frequencies which differ by a frequency difference δω; (c) applying a radio frequency refocusing pulse for inducing a spin echo a duration τ after the refocusing pulse; (d) applying a read gradient concurrently with the spin echo; (e) applying further gradient pulses of opposite polarity to induce at least first and second gradient echoes offset by times ±(2n+1)π/δω from the spin echo, where n is an integer, such that the first and second gradient echoes have phase components that are offset by 180° from the spin echo; (f) applying phase encode gradients such that the spin echo and the first and second gradient echoes have a common phase encoding; (g) repeating at least steps (b)-(f) with different phase encode gradients to generate a plurality of differently phase encoded spin echo resonance signals, first gradient echo resonance signals, and second gradient echo resonance signals; (h) reconstructing the spin echo, the first gradient echo, and the second gradient echo resonance signals into a spin echo image, a first gradient echo image, and a second gradient echo image; (i) generating a phase correction map from the spin echo and first and second gradient echo images; (j) correcting a phase of one of the gradient echo images with the phase map; (k) additively combining the phase corrected image with the spin echo image which is 180° out-of-phase therewith to generate a first species image; and, (l) subtractively combining the phase corrected image with the 180° out-of-phase spin echo image to generate a second species image.

Claim 10

Dependent Claim 10 words

The method as set forth in claim 6 where n=1.

Claim 11

Dependent Claim 27 words

The method as set forth in claim 6 wherein the first and second gradient echoes are induced at equal time intervals before and after the spin echo.

Claim 12

Dependent Claim 38 words

The method as set forth in claim 6 wherein in step (i), the phase correction map is a phase image and step (j) includes combining the phase image with one of the first and second gradient echo images.

Claim 13

Dependent Claim 31 words

The method as set forth in claim 6 wherein step (i) includes combining the gradient echo and spin echo images and normalizing the gradient echo images with the spin echo image.

Claim 14

Dependent Claim 42 words

The method as set forth in claim 6 wherein the spin echo is generated when the first and second species are in-phase with each other and gradient echoes are generated when the first and second species are 180° out-of-phase with each other.

Claim 15

Dependent Claim 148 words

The method as set forth in claim 11 wherein step (b) further includes exciting resonance in a third species of dipole within the subject, the third species having a resonance frequency which differs from the first species resonance frequency by a frequency difference δω', the method further including: inducing third and fourth gradient echoes centered at times mπ/δω' before and after a center of the spin echo, where m is an odd integer; generating a phase correction map based on the third and fourth gradient echoes and the spin echo; correcting one of the third and fourth gradient echo images with the phase map; subtractively combining the spin echo and the phase error corrected one of the third and fourth gradient echo images to generate a third species image; reconstructing magnetic resonance signals from the third and fourth gradient echoes into third and fourth gradient echo images, respectively.

Claim 16

Dependent Claim 202 words

In a magnetic resonance imaging apparatus which includes a primary magnet for generating a temporally constant magnetic field, a gradient magnetic field coil for generating magnetic field gradients across an imaging region, one or more radio frequency coils for inducing and refocusing magnetic resonance of dipoles of first and second species within the imaging region and for receiving magnetic resonance signals from the resonating first and second species dipoles in the examination region, the first and second species dipoles having resonance frequencies which differ by a frequency difference δω, the improvement comprising: a timing and control circuit for controlling the radio frequency and gradient coils to excite magnetic resonance, refocus the magnetic resonance to induce a spin echo, and inducing gradient echoes centered at times nπ/δω before and after a center of the spin echo, where n is an odd integer; a reconstruction processor for reconstructing magnetic resonance signals from the spin echo into a spin echo image, for reconstructing magnetic resonance signals from the gradient echoes into a first gradient echo image and a second gradient echo image; a phase mad generator which generates a phase correction map from the spin echo image and the first and second gradient echo images.

Claim 17

Dependent Claim 202 words

In a magnetic resonance imaging apparatus which includes a primary magnet for generating a temporally constant magnetic field, a gradient magnetic field coil for generating magnetic field gradients across an imaging region, one or more radio frequency coils for inducing and refocusing magnetic resonance of dipoles of first and second species within the imaging region and for receiving magnetic resonance signals from the resonating first and second species dipoles in the examination region, the first and second species dipoles having resonance frequencies which differ by a frequency difference δω, the improvement comprising: a timing and control circuit for controlling the radio frequency and gradient coils to excite magnetic resonance, refocus the magnetic resonance to induce a spin echo, and inducing gradient echoes centered at times nπ/δω before and after a center of the spin echo, where n is an odd integer; a reconstruction processor for reconstructing magnetic resonance signals from the spin echo into a spin echo image, for reconstructing magnetic resonance signals from the gradient echoes into a first gradient echo image and a second gradient echo image; a phase mad generator which generates a phase correction map from the spin echo image and the first and second gradient echo images.

Claim 18

Dependent Claim 285 words

In a magnetic resonance imaging apparatus which includes a primary magnet for generating a temporally constant magnetic field, a gradient magnetic field coil for generating magnetic field gradients across an imaging region, one or more radio frequency coils for inducing and refocusing magnetic resonance of dipoles of first and second species within the imaging region and for receiving magnetic resonance signals from the resonating first and second species dipoles in the examination region, the first and second species dipoles having resonance frequencies which differ by a frequency difference δω, the improvement comprising: a timing and control circuit for controlling the radio frequency and gradient coils to excite magnetic resonance, refocus the magnetic resonance to induce a spin echo, and inducing first and second gradient echoes centered at times nπ/δω before and after a center of the spin echo, where n is an odd integer; a reconstruction processor for reconstructing magnetic resonance signals from the spin echo into a spin echo image, for reconstructing magnetic resonance signals from the first gradient echo into a first gradient echo image, and for reconstructing magnetic resonance signals from the second gradient echo into a second gradient echo image; a phase map generator which generates a phase correction map from the spin echo image and the first and second gradient echo images; a circuit which corrects one of the gradient echo images with the phase map to generate a phase map corrected gradient echo image; an image adder which adds the spin echo and the phase corrected gradient echo images to generate a first species dipole image; an image subtractor which subtractively combines the spin echo and the phase corrected gradient echo images to generate a second species dipole image.

Claim 19

Dependent Claim 285 words

In a magnetic resonance imaging apparatus which includes a primary magnet for generating a temporally constant magnetic field, a gradient magnetic field coil for generating magnetic field gradients across an imaging region, one or more radio frequency coils for inducing and refocusing magnetic resonance of dipoles of first and second species within the imaging region and for receiving magnetic resonance signals from the resonating first and second species dipoles in the examination region, the first and second species dipoles having resonance frequencies which differ by a frequency difference δω, the improvement comprising: a timing and control circuit for controlling the radio frequency and gradient coils to excite magnetic resonance, refocus the magnetic resonance to induce a spin echo, and inducing first and second gradient echoes centered at times nπ/δω before and after a center of the spin echo, where n is an odd integer; a reconstruction processor for reconstructing magnetic resonance signals from the spin echo into a spin echo image, for reconstructing magnetic resonance signals from the first gradient echo into a first gradient echo image, and for reconstructing magnetic resonance signals from the second gradient echo into a second gradient echo image; a phase map generator which generates a phase correction map from the spin echo image and the first and second gradient echo images; a circuit which corrects one of the gradient echo images with the phase map to generate a phase map corrected gradient echo image; an image adder which adds the spin echo and the phase corrected gradient echo images to generate a first species dipole image; an image subtractor which subtractively combines the spin echo and the phase corrected gradient echo images to generate a second species dipole image.

Claim 20

Dependent Claim 207 words

In a magnetic resonance imaging method in which a resonance excitation pulse and resonance refocusing pulse are applied to generate a spin echo and in which a read gradient is reversed in order to induce a trailing gradient echo in association with each spin echo, the improvement comprising: reversing a polarity of the read gradient to induce a leading gradient echo at a time when resonance signals from first and second species are substantially 180° out-of-phase; reading out the leading gradient echo when the read gradient has a first polarity; inducing the spin echo when resonance signals of a first and second species are substantially in-phase; reading out the spin echo when the read gradient has a second polarity opposite to the first polarity; reversing the polarity of the read gradient to induce the trailing gradient echo at a time when the resonance signals of the first and second species are substantially 180° out-of-phase such that an in-phase spin echo and out-of-phase leading and trailing gradient echoes are generated in each repetition of the imaging sequence; reading out the trailing gradient echo when the read gradient has the first polarity; and, generating a phase correction map from the leading and trailing gradient echoes and the spin echo.

Claim 21

Dependent Claim 207 words

In a magnetic resonance imaging method in which a resonance excitation pulse and resonance refocusing pulse are applied to generate a spin echo and in which a read gradient is reversed in order to induce a trailing gradient echo in association with each spin echo, the improvement comprising: reversing a polarity of the read gradient to induce a leading gradient echo at a time when resonance signals from first and second species are substantially 180° out-of-phase; reading out the leading gradient echo when the read gradient has a first polarity; inducing the spin echo when resonance signals of a first and second species are substantially in-phase; reading out the spin echo when the read gradient has a second polarity opposite to the first polarity; reversing the polarity of the read gradient to induce the trailing gradient echo at a time when the resonance signals of the first and second species are substantially 180° out-of-phase such that an in-phase spin echo and out-of-phase leading and trailing gradient echoes are generated in each repetition of the imaging sequence; reading out the trailing gradient echo when the read gradient has the first polarity; and, generating a phase correction map from the leading and trailing gradient echoes and the spin echo.

Claim 22

Dependent Claim 32 words

In the method as set forth in claim 15, the improvement further including phase encoding the spin and gradient echoes with a common phase encoding in each of a plurality of repetitions.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	2000-01-14	2000-07-15	2001-01-14	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2004-01-14	2004-07-15	2005-01-14	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2008-01-14	2008-07-15	2009-01-14	$7700.00	Window Closed / Lapsed

Three point technique using spin and gradient echoes for water/fat separation

Abstract

Inventors

Bibliographic Details

Claims Analysis

References Cited (Backward Citations)

USPTO Annuity & Maintenance Windows

Assigned Categories & Tags

Assign Category Tag