US5591624A
Copy Number
Expired / Lapsed
US
⏱️ 0.0 years remaining
Retroviral packaging cell lines
Assignee: Oxford Biomedica UK Ltd
•
Filing: 1993-11-23
•
Granted: 1997-01-07
•
Expires: 2013-11-23
Overview & Biblio
Claims (10)
Citations (11)
Maintenance Schedule (3)
Categories & Tags (0)
Abstract
Abstract The invention described herein allows the production of recombinant retroviruses (retroviral vector particles) from producer cells which are safer and of higher titer than normal. In addition, methods are provided for making helper cells which, when a recombinant retrovirus genome is introduced to make a producer line, produce particles that are targeted toward particular cell types. Methods are also provided for making recombinant retrovirus systems adapted to infect a particular cell type, such as a tumor, by binding the retrovirus or recombinant retrovirus in the particular cell type. Methods are also provided for producing recombinant retroviruses which integrate in a specific small number of places in the host genome, and for producing recombinant retroviruses from transgenic animals.
Inventors
👤 Jack R. Barber
👤 Douglas J. Jolly
👤 James G. Respess
👤 Stephen M. W. Chang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 20:51
CPC Classifications
A; A01; A01K; A01K67/00; A01K67/027; A01K67/0275; C; C07; C07K; C07K14/00; C07K14/005; C07K14/435; C07K14/705; C07K14/70503; C07K14/70514; C12; C12N; C12N15/00; C12N15/09; C12N15/63; C12N15/79; C12N15/85; C12N15/8509; C12N15/86; C12N7/00; A01K2217/00; A01K2217/05; A01K2217/30; A01K2227/00; A01K2227/10; A01K2227/105; A01K2267/00; A01K2267/01; A61; A61K; A61K39/00; A61K2039/51; A61K2039/525; A61K2039/5256; A61K2039/53; A61K2039/57; A61K48/00; C07K2319/00; C12N2740/00; C12N2740/00011; C12N2740/10011; C12N2740/11011; C12N2740/11041; C12N2740/11043; C12N2740/11051; C12N2740/11052; C12N2740/13011; C12N2740/13022; C12N2740/13023; C12N2740/13041; C12N2740/13043; C12N2740/13051; C12N2740/13052; C12N2740/15011; C12N2740/15022; C12N2740/16011; C12N2740/16023; C12N2740/16211; C12N2740/16222; C12N2830/00; C12N2830/008
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
18 words
A retroviral packaging cell line, wherein the packaging cell line is generated from a human host cell line.
Claim 2
Dependent Claim
18 words
A retroviral packaging cell line, wherein the packaging cell line is generated from a human host cell line.
Claim 3
Dependent Claim
20 words
The retroviral packaging cell line of claim 1, wherein the retroviral packaging cell line is an amphotropic packaging cell line.
Claim 4
Dependent Claim
20 words
The retroviral packaging cell line of claim 1, wherein the retroviral packaging cell line is a polytropic packaging cell line.
Claim 5
Dependent Claim
20 words
The retroviral packaging cell line of claim 1, wherein the retroviral packaging cell line is a xenotropic packaging cell line.
Claim 6
Dependent Claim
19 words
The retroviral packaging cell line of claim 1, wherein the human host cell line is the cell line 293.
Claim 7
Dependent Claim
19 words
The retroviral packaging cell line of claim 1, wherein the human host cell line is the cell line HT1080.
Claim 8
Dependent Claim
20 words
The retroviral packaging cell line of claim 5 which is the packaging cell line 2A having ATCC No. CRL 12013.
Claim 9
Dependent Claim
20 words
The retroviral packaging cell line of claim 6 which is the packaging cell line HP having ATCC No. CRL 12012.
Claim 10
Dependent Claim
20 words
The retroviral packaging cell line of claim 6 which is the packaging cell line HX having ATCC No. CRL 12011.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
Annuity Stage
Window Opens
Payment Deadline
Surcharge Period Until
Estimated Fee
Status
3.5 Years (Year 4) 2000-01-07
2000-07-08 2001-01-07
$2000.00
Window Closed / Lapsed
7.5 Years (Year 8) 2004-01-07
2004-07-08 2005-01-07
$3760.00
Window Closed / Lapsed
11.5 Years (Year 12) 2008-01-07
2008-07-08 2009-01-07
$7700.00
Window Closed / Lapsed