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US5585270A
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Polynucleotides encoding connective tissue growth factor
Assignee: University of South Florida St. Petersburg
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Filing: 1995-02-10
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Granted: 1996-12-17
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Expires: 2015-02-10
Abstract
Abstract Polynucleotides encoding connective tissue growth factor (CTGF) are provided. An exemplary polynucleotide of the invention is shown in SEQ ID NO:1. Expression vectors containing CTGF polynucleotide and host cells containing such expression vectors are also included in the invention.
Inventors
- 👤 Gary R. Grotendorst
- 👤 Douglass M. Bradham, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 18:50
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/22; C07K14/00; C07K14/435; C07K14/475; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/12
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
54 words
An isolated polynucleotide encoding connective tissue growth factor (CTGF) polypeptide, wherein CTGF is characterized by: a) mitogenic and chemotactic activity for connective tissue cells; b) a molecular weight of approximately 36 kD by non-reducing SDS-PAGE and approximately 38 kD by reducing SDS-PAGE; c) binding to a PDGF receptor; and d) existing as a monomer.
Claim 2
Dependent Claim
54 words
An isolated polynucleotide encoding connective tissue growth factor (CTGF) polypeptide, wherein CTGF is characterized by: a) mitogenic and chemotactic activity for connective tissue cells; b) a molecular weight of approximately 36 kD by non-reducing SDS-PAGE and approximately 38 kD by reducing SDS-PAGE; c) binding to a PDGF receptor; and d) existing as a monomer.
Claim 3
Dependent Claim
11 words
The polynucleotide sequence of claim 1, wherein the polynucleotide is DNA.
Claim 4
Dependent Claim
10 words
The polynucleotide of claim 2, wherein the DNA is cDNA.
Claim 5
Dependent Claim
11 words
A biologically functional expression vector containing the polynucleotide of claim 1.
Claim 6
Dependent Claim
15 words
The vector of claim 4, wherein the vector is a plasmid or a viral vector.
Claim 7
Dependent Claim
13 words
A host cell stably transformed or transfected with a vector of claim 4.
Claim 8
Dependent Claim
12 words
The host cell of claim 6, wherein the host is a prokaryote.
Claim 9
Dependent Claim
12 words
The host cell of claim 6, wherein the host is a eukaryote.
Claim 10
Dependent Claim
15 words
The polynucleotide of claim 1, wherein the polynucleotide encodes the CTGF of SEQ ID NO:2.
Claim 11
Dependent Claim
12 words
The polynucleotide of claim 1 as set forth in SEQ ID NO:1.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-12-17 | 2000-06-17 | 2000-12-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-12-17 | 2004-06-17 | 2004-12-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-12-17 | 2008-06-17 | 2008-12-17 | $7700.00 | Window Closed / Lapsed |