US5578061A
Expired / Lapsed
US
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Method and apparatus for cardiac therapy by stimulation of a physiological representative of the parasympathetic nervous system
Assignee: Pacesetter AB
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Filing: 1995-10-03
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Granted: 1996-11-26
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Expires: 2015-10-03
Abstract
Abstract A device for heart therapy has a tacharrythmia detector unit, a control unit and a current generator. The current generator controlled by the control unit emits via an electrode system a first, pulsed current to a physiological representative of the parasympathetic nervous system in order to activate same in response to detection of an impending or established arrhythmia. The current generator is further caused by the control unit, in the event of tachyarrythmia detection to emit, via the electrode system, a second current to a physiological representative of the sympathetic nervous system in order to block same.
Inventors
- 👤 Brigitte Stroetmann
- 👤 Nils Holmstrom
- 👤 Siegfried Kallert
- 👤 Staffan Bowald
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 07:31
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/32; A61N1/38; A61N1/39; A61N1/3956; A61N1/3962; A61N1/39622; A61N1/36; A61N1/3605; A61N1/3606; A61N1/36114
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
125 words
An apparatus for providing therapy to the heart of a subject, comprising: a tachyarrhythmia detector means for detecting tachyarrhythmia of said heart; a current generator; an electrode system means connectable for delivering current from said current generator in vivo to the parasympathetic nervous system of said subject and for delivering current from said current generator in vivo to the sympathetic nervous system of said subject; and control means for causing said current generator, upon detection of tachyarrhythmia by said tachyarrhythmia detector, to emit a first, pulsed current via said electrode system to the parasympathetic nervous system in order to activate said parasympathetic nervous system and to emit a second current via said electrode system to the sympathetic nervous system for blocking said sympathetic nervous system.
Claim 2
Independent Claim
125 words
An apparatus for providing therapy to the heart of a subject, comprising: a tachyarrhythmia detector means for detecting tachyarrhythmia of said heart; a current generator; an electrode system means connectable for delivering current from said current generator in vivo to the parasympathetic nervous system of said subject and for delivering current from said current generator in vivo to the sympathetic nervous system of said subject; and control means for causing said current generator, upon detection of tachyarrhythmia by said tachyarrhythmia detector, to emit a first, pulsed current via said electrode system to the parasympathetic nervous system in order to activate said parasympathetic nervous system and to emit a second current via said electrode system to the sympathetic nervous system for blocking said sympathetic nervous system.
Claim 3
Dependent Claim
64 words
An apparatus as claimed in claim 1 wherein said current generator includes a first nerve stimulator from which said first, pulsed current is emitted, and wherein said control means comprises means for causing said first nerve stimulator to emit pulses each having a pulse width in a range of 0.1-1.0 ms in a sequence with a pulse interval in a range from 20-50 ms.
Claim 4
Dependent Claim
29 words
An apparatus as claimed in claim 2 wherein said control means comprises means for causing said first stimulator to emit said pulses with a pulse width of 0.5 ms.
Claim 5
Dependent Claim
81 words
An apparatus as claimed in claim 2 wherein said current generator includes a second nerve stimulator which emits said second current, said second nerve stimulator having opposite polarity with respect to said first nerve stimulator, and said control means comprises means for causing said second nerve stimulator to emit said second current in the form of pulses each having a pulse width in a range from 0.1-1.0 ms in a sequence with a pulse interval in a range from 2-5 ms.
Claim 6
Dependent Claim
30 words
An apparatus as claimed in claim 4 wherein said control means comprises means for causing said second nerve stimulator to emit said pulses with a pulse width of 0.5 ms.
Claim 7
Dependent Claim
21 words
An apparatus as claimed in claim 1 wherein said current generator comprises means for emitting said second current as direct current.
Claim 8
Dependent Claim
22 words
An apparatus as claimed in claim 1 wherein said current generator comprises means for emitting said second current as a square wave.
Claim 9
Dependent Claim
35 words
An apparatus as claimed in claim 1 wherein said electrode system comprises at least one first nerve electrode for the parasympathetic nervous system and at least one second nerve electrode for the sympathetic nervous system.
Claim 10
Dependent Claim
40 words
An apparatus as claimed in claim 8 wherein said first nerve electrode comprises a first sub-electrode connectable distally relative to the heart and a second sub-electrode connectable proximally with respect to said heart, at a distance from said first sub-electrode.
Claim 11
Dependent Claim
52 words
An apparatus as claimed in claim 9 wherein said current generator comprises a nerve stimulator having a positive output and a negative output from which said first, pulsed current is emitted, and wherein said first sub-electrode is connected to said positive output and said second sub-electrode is connected to said negative output.
Claim 12
Dependent Claim
38 words
An apparatus as claimed in claim 8 wherein said second nerve electrode comprises a first sub-electrode connectable distally relative to said heart and a second sub-electrode connectable proximally with said heart, at a distance from said first sub-electrode.
Claim 13
Dependent Claim
50 words
An apparatus as claimed in claim 11 wherein said current generator includes a nerve stimulator having a positive output and a negative output, and wherein said first sub-electrode is connected to said negative output of said second nerve stimulator and wherein said second sub-electrode is connected to said positive output.
Claim 14
Dependent Claim
22 words
An appartus as claimed in claim 12 wherein said second nerve stimulator comprises a direct current source having said positive and negative.
Claim 15
Dependent Claim
74 words
An apparatus as claimed in claim 1 further comprising means for generating pacing pulses and means for generating and delivering defibrillation/cardioversion pulses, and wherein said control means comprises means for controlling said current generator, said means for generating pacing pulses and said means for generating defibrillation/cardioversion pulses, in combination, for delivering a combination of said pacing pulses and said defibrillation/cardioversion pulses to said subject matched to terminate the tachyarrhythmia detected by said tachyarrhythmia detector.
Claim 16
Independent Claim
69 words
A method for providing therapy to the heart of a subject, comprising the steps of: detecting tachyarrhythmia of said heart; and upon detection of tachyarrhythmia, delivering a first, pulsed current in vivo to the parasympathetic nervous system of said subject in order to activate said parasympathetic nervous system and delivering a second current in vivo to the sympathetic nervous system of said subject for blocking said sympathetic nervous system.
Claim 17
Independent Claim
69 words
A method for providing therapy to the heart of a subject, comprising the steps of: detecting tachyarrhythmia of said heart; and upon detection of tachyarrhythmia, delivering a first, pulsed current in vivo to the parasympathetic nervous system of said subject in order to activate said parasympathetic nervous system and delivering a second current in vivo to the sympathetic nervous system of said subject for blocking said sympathetic nervous system.
Claim 18
Dependent Claim
43 words
A method as claimed in claim 15 wherein the step of delivering said first, pulsed current comprises delivering pulses each having a pulse width in a range of 0.1-1.0 ms in a sequence with a pulse interval in a range from 20-50 ms.
Claim 19
Dependent Claim
27 words
A method as claimed in claim 16 wherein the steps of delivering said first, pulsed current comprises delivering said pulses with a pulses width of 0.5 ms.
Claim 20
Dependent Claim
58 words
A method as claimed in claim 16 wherein the step of delivering said second current comprises delivering said second current, with a polarity opposite to said first, pulsed current in the form of pulses each having a pulse width in a range from 0.1-1.0 ms in a sequence with a pulse interval in a range from 2-5 ms.
Claim 21
Dependent Claim
26 words
A method as claimed in claim 18 wherein the step of delivering said second current comprises delivering said pulses with a pulse width of 0.5 ms.
Claim 22
Dependent Claim
22 words
A method as claimed in claim 15 wherein the step of delivering second current comprises delivering said second current as direct current.
Claim 23
Dependent Claim
24 words
A method as claimed in claim 15 wherein the step of delivering said second current comprises delivering said second current as a square wave.
Claim 24
Dependent Claim
81 words
A method as claimed in claim 13 comprising the additional steps of implanting a first sub-electrode in said subject in contact with said parasympathetic nervous system distally relative to the heart and implanting a second sub-electrode in said subject in contact with said parasympathetic nervous system proximally with respect to said heart, at a distance from said first sub-electrode and wherein the step of delivering said first, pulsed current comprises delivering said first, pulsed current via said first and second sub-electrodes.
Claim 25
Dependent Claim
52 words
A method as claimed in claim 22 comprising the additional steps of implanting a nerve stimulator in said subject having a positive output and a negative output from which said first, pulsed current is emitted, connecting said first sub-electrode to said positive output and connecting said second sub-electrode to said negative output.
Claim 26
Dependent Claim
79 words
A method as claimed in claim 15 comprising the additional steps of implanting a first sub-electrode in said subject in contact with said sympathetic nervous system distally relative to the heart and implanting a second sub-electrode in said subject in contact with said sympathetic nervous system proximally with respect to said heart, at a distance from said first sub-electrode, and wherein the step of delivering said second current comprises delivering said second current via said first and second sub-electrodes.
Claim 27
Dependent Claim
54 words
A method as claimed in claim 24 comprising the additional steps of implanting a nerve stimulator in said subject having a positive output and a negative output, connecting said first sub-electrode to said negative output of said second nerve stimulator, and connecting said second sub-electrode to said positive output of said second nerve stimulator.
Claim 28
Dependent Claim
33 words
A method as claimed in claim 25 wherein the step of implanting said second nerve stimulator comprises implanting a direct current source having said positive and negative outputs as said second nerve stimulator.
Claim 29
Dependent Claim
60 words
A method as claimed in claim 15 comprising the additional steps of generating pacing pulses and generating defibrillation/cardioversion pulses, and controlling the delivery of said first, pulsed current, delivery of said second current, generation of said pacing pulses and for generation of said defibrillation/cardioversion pulses, in combination, for delivering electrical therapy to said subject matched to terminate the detected tachyarrythmia.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-11-26 | 2000-05-27 | 2000-11-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-11-26 | 2004-05-27 | 2004-11-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-11-26 | 2008-05-27 | 2008-11-26 | $7700.00 | Window Closed / Lapsed |