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US5569308A
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Methods for use in bone tissue regeneration
Assignee: Individual
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Filing: 1994-09-06
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Granted: 1996-10-29
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Expires: 2014-09-06
Abstract
Abstract The present invention provides methods for use in bone tissue regeneration containing a barrier material and a graft material. The barrier material can be calcium sulfate, while the graft material can be any suitable material, including a composite graft material containing demineralized, freeze-dried, allogenic bone (DFDBA) and calcium sulfate. Alternatively, the barrier material can be any suitable material, while the graft material can be a composition of DFDBA and calcium sulfate.
Inventors
- 👤 John S. Sottosanti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:19
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/02; A61L27/025; A61F; A61F2/00; A61F2/02; A61F2/28; A61L27/36; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/365; A61F2/2803; A61F2002/2835; A61L2430/00; A61L2430/02; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/919
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
130 words
A method of regenerating bone tissue, comprising: (a) filling a recipient graft site with graft material, the graft material comprising a stimulus to bone tissue growth, wherein the stimulus to bone tissue growth is selected from the group consisting of a bone forming cell, an inducer of bone tissue growth, a scaffolding-type structure that actively attracts osteoblasts, a scaffolding-type structure that passively attracts osteoblasts, and a combination of any of these; and (b) placing a layer of resorbable barrier material over at least a portion of the graft material, wherein the barrier material comprises calcium sulfate, and wherein the barrier material physically protects the graft material, retards the ingrowth of unwanted tissue into the graft material, and allows cells to migrate into the recipient graft site from adjacent osseous tissue.
Claim 2
Independent Claim
130 words
A method of regenerating bone tissue, comprising: (a) filling a recipient graft site with graft material, the graft material comprising a stimulus to bone tissue growth, wherein the stimulus to bone tissue growth is selected from the group consisting of a bone forming cell, an inducer of bone tissue growth, a scaffolding-type structure that actively attracts osteoblasts, a scaffolding-type structure that passively attracts osteoblasts, and a combination of any of these; and (b) placing a layer of resorbable barrier material over at least a portion of the graft material, wherein the barrier material comprises calcium sulfate, and wherein the barrier material physically protects the graft material, retards the ingrowth of unwanted tissue into the graft material, and allows cells to migrate into the recipient graft site from adjacent osseous tissue.
Claim 3
Dependent Claim
12 words
The method of claim 1, wherein the barrier material further comprises rehydrant.
Claim 4
Dependent Claim
17 words
The method of claim 1, wherein the barrier material is substantially free from calcium phosphate ceramic particles.
Claim 5
Dependent Claim
11 words
The method of claim 1, wherein the barrier material is pre-set.
Claim 6
Dependent Claim
14 words
The method of claim 1, wherein the barrier material is in a paste form.
Claim 7
Dependent Claim
17 words
The method of claim 1, further comprising covering the layer of barrier material with a protective material.
Claim 8
Dependent Claim
18 words
The method of claim 1, wherein the graft material comprises demineralized, freeze-dried allogenic bone (DFDBA) and calcium sulfate.
Claim 9
Dependent Claim
20 words
The method of claim 7, wherein the graft material comprises about eighty percent DFDBA and about twenty percent calcium sulfate.
Claim 10
Dependent Claim
17 words
The method of claim 8, further comprising covering the layer of barrier material with a protective material.
Claim 11
Dependent Claim
14 words
The method of claim 1, wherein the barrier material consists essentially of calcium sulfate.
Claim 12
Dependent Claim
11 words
The method of claim 10, wherein the barrier material is pre-set.
Claim 13
Dependent Claim
14 words
The method of claim 10, wherein the barrier material is in a paste form.
Claim 14
Dependent Claim
18 words
The method of claim 10, wherein the graft material comprises demineralized, freeze-dried allogenic bone (DFDBA) and calcium sulfate.
Claim 15
Dependent Claim
20 words
The method of claim 13, wherein the graft material comprises about eighty percent DFDBA and about twenty percent calcium sulfate.
Claim 16
Dependent Claim
20 words
The method of claim 14, further comprising the step of covering the layer of barrier material with a protective material.
Claim 17
Dependent Claim
34 words
A method in accordance with claim 10, wherein the barrier material creates a solid physical barrier that is sufficiently dense to retard ingrowth of unwanted tissue, and yet porous enough to allow fluid exchange.
Claim 18
Dependent Claim
18 words
A method in accordance with claim 1, wherein the stimulus to bone growth is a bone forming cell.
Claim 19
Dependent Claim
16 words
A method in accordance with claim 17, wherein the barrier material consists essentially of calcium sulfate.
Claim 20
Dependent Claim
20 words
A method in accordance with claim 1, wherein the stimulus to bone growth is an inducer of bone tissue growth.
Claim 21
Dependent Claim
16 words
A method in accordance with claim 19, wherein the barrier material consists essentially of calcium sulfate.
Claim 22
Dependent Claim
21 words
A method in accordance with claim 1, wherein the stimulus to bone growth is a scaffolding-type structure that actively attracts osteoblasts.
Claim 23
Dependent Claim
16 words
A method in accordance with claim 21, wherein the barrier material consists essentially of calcium sulfate.
Claim 24
Dependent Claim
21 words
A method in accordance with claim 1, wherein the stimulus to bone growth is a scaffolding-type structure that passively attracts osteoblasts.
Claim 25
Dependent Claim
16 words
A method in accordance with claim 23, wherein the barrier material consists essentially of calcium sulfate.
Claim 26
Dependent Claim
34 words
A method in accordance with claim 1, wherein the barrier material creates a solid physical barrier that is sufficiently dense to retard ingrowth of unwanted tissue, and yet porous enough to allow fluid exchange.
Claim 27
Independent Claim
108 words
A method of regenerating bone tissue, comprising: (a) filling a recipient graft site with graft material, the graft material comprising a stimulus to bone tissue growth, wherein the stimulus to bone tissue growth is selected from the group consisting of a bone forming cell, an inducer of bone tissue growth, a scaffolding-type structure that actively attracts osteoblasts, a scaffolding-type structure that passively attracts osteoblasts, and a combination of any of these; and (b) placing a layer of resorbable barrier material over at least a portion of the graft material, wherein the barrier material consists essentially of calcium sulfate, and wherein the barrier material physically protects the graft material.
Claim 28
Independent Claim
108 words
A method of regenerating bone tissue, comprising: (a) filling a recipient graft site with graft material, the graft material comprising a stimulus to bone tissue growth, wherein the stimulus to bone tissue growth is selected from the group consisting of a bone forming cell, an inducer of bone tissue growth, a scaffolding-type structure that actively attracts osteoblasts, a scaffolding-type structure that passively attracts osteoblasts, and a combination of any of these; and (b) placing a layer of resorbable barrier material over at least a portion of the graft material, wherein the barrier material consists essentially of calcium sulfate, and wherein the barrier material physically protects the graft material.
Claim 29
Dependent Claim
34 words
A method in accordance with claim 26, wherein the barrier material creates a solid physical barrier that is sufficiently dense to retard ingrowth of unwanted tissue, and yet porous enough to allow fluid exchange.
Claim 30
Independent Claim
113 words
A method of regenerating bone tissue, comprising: (a) filling a recipient graft site with graft material, the graft material comprising a stimulus to bone tissue growth, wherein the stimulus to bone tissue growth is selected from the group consisting of a bone forming cell, an inducer of bone tissue growth, a scaffolding-type structure that actively attracts osteoblasts, a scaffolding-type structure that passively attracts osteoblasts, and a combination of any of these; and (b) placing a layer of resorbable barrier material over at least a portion of the graft material, wherein the barrier material consists essentially of calcium sulfate, and wherein the barrier material retards the ingrowth of unwanted tissue into the graft material.
Claim 31
Independent Claim
113 words
A method of regenerating bone tissue, comprising: (a) filling a recipient graft site with graft material, the graft material comprising a stimulus to bone tissue growth, wherein the stimulus to bone tissue growth is selected from the group consisting of a bone forming cell, an inducer of bone tissue growth, a scaffolding-type structure that actively attracts osteoblasts, a scaffolding-type structure that passively attracts osteoblasts, and a combination of any of these; and (b) placing a layer of resorbable barrier material over at least a portion of the graft material, wherein the barrier material consists essentially of calcium sulfate, and wherein the barrier material retards the ingrowth of unwanted tissue into the graft material.
Claim 32
Dependent Claim
34 words
A method in accordance with claim 28, wherein the barrier material creates a solid physical barrier that is sufficiently dense to retard ingrowth of unwanted tissue, and yet porous enough to allow fluid exchange.
Claim 33
Independent Claim
116 words
A method of regenerating bone tissue, comprising: (a) filling a recipient graft site with graft material, the graft material comprising a stimulus to bone tissue growth, wherein the stimulus to bone tissue growth is selected from the group consisting of a bone forming cell, an inducer of bone tissue growth, a scaffolding-type structure that actively attracts osteoblasts, a scaffolding-type structure that passively attracts osteoblasts, and a combination of any of these; and (b) placing a layer of resorbable barrier material over at least a portion of the graft material, wherein the barrier material consists essentially of calcium sulfate, and wherein the barrier material allows cells to migrate into the recipient graft site from adjacent osseous tissue.
Claim 34
Independent Claim
116 words
A method of regenerating bone tissue, comprising: (a) filling a recipient graft site with graft material, the graft material comprising a stimulus to bone tissue growth, wherein the stimulus to bone tissue growth is selected from the group consisting of a bone forming cell, an inducer of bone tissue growth, a scaffolding-type structure that actively attracts osteoblasts, a scaffolding-type structure that passively attracts osteoblasts, and a combination of any of these; and (b) placing a layer of resorbable barrier material over at least a portion of the graft material, wherein the barrier material consists essentially of calcium sulfate, and wherein the barrier material allows cells to migrate into the recipient graft site from adjacent osseous tissue.
Claim 35
Dependent Claim
34 words
A method in accordance with claim 30, wherein the barrier material creates a solid physical barrier that is sufficiently dense to retard ingrowth of unwanted tissue, and yet porous enough to allow fluid exchange.
References Cited (Backward Citations)
US4619655A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-10-29 | 2000-04-29 | 2000-10-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-10-29 | 2004-04-29 | 2004-10-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-10-29 | 2008-04-29 | 2008-10-29 | $7700.00 | Window Closed / Lapsed |