Non-destructive fill volume measurement system

Claim 2

A non-destructive method of determining a fill volume of a first fluid in a sealed container that also contains a second fluid having a lower density than the first fluid, the container having a substantially symmetrical central region, comprising the steps of: determining a common volume within the central region of the container intermediate an upright fluid level and an inverted fluid level, such that the first fluid fill volume equals a sum of the second fluid volume plus the common volume; determining the second fluid volume; and summing the second fluid volume and the common volume to determine the first fluid fill volume.

Claim 3

A method according to claim 1 wherein said determining the second fluid volume includes rotating the container about a selected axis of rotation so as to confine the second fluid to the central region of the container, and measuring the second fluid volume within the central region while the container is rotating.

Claim 4

A method according to claim 2 wherein said rotating step includes selecting a speed of rotation such that the second fluid volume forms a substantially cylindrical pocket symmetrically disposed about the axis of rotation, the pocket being substantially surrounded by the first fluid; and said measuring the second fluid volume includes measuring a size of the pocket while the container is so rotating.

Claim 5

A method according to claim 3 wherein the selected speed of rotation is within a range of approximately 200 to 7000 rpm.

Claim 6

A method according to claim 3 further comprising providing a machine vision system including an electronic imaging means for capturing an image of the pocket along the said axis of rotation, and wherein said measuring the size of the pocket includes measuring a diameter of the pocket from the captured image.

Claim 7

A method according to claim 1 wherein said determining the common volume includes: determining an inside diameter of the container in the central region; positioning the container in an upright orientation; measuring the upright fluid level at a first interface of the first fluid and the second fluid; inverting the container; measuring the inverted fluid level at a second interface of the first fluid and the second fluid; and calculating the common volume based upon the inside diameter and a distance between the upright and inverted fluid levels.

Claim 8

A method according to claim 6 wherein said measuring the upright and inverted fluid levels includes providing a machine vision system including an electronic imaging means for capturing an image of the container; capturing an image of the container in each of the upright and inverted orientations; and determining said fluid levels from the respective captured images.

Claim 9

A method according to claim 7 further comprising providing a predetermined origin line in the captured image, and measuring the said fluid levels relative to the origin line.

Claim 10

A method according to claim 7 further comprising directing a source of electromagnetic radiation having a desired wavelength through the container toward the imaging means; and filtering electromagnetic radiation entering the imaging means so that only electromagnetic radiation having substantially the desired wavelength enters the imaging means.

Claim 11

A method according to claim 9 further comprising obscuring a predetermined portion of the electromagnetic radiation source so as to provide an origin in the captured images, and wherein said determining the fluid levels includes gauging a distance in the images intermediate the respective fluid levels and the origin.

Claim 12

A method according to claim 9 wherein the source of electromagnetic radiation comprises an infrared light source.

Claim 13

A method according to claim 7 wherein said determining the inside diameter includes providing a predetermined wall thickness; measuring the outside diameter of the container; and calculating the inside diameter as the outside diameter less the wall thickness.

Claim 14

A method according to claim 1 wherein the first fluid comprises a liquid and second fluid comprises air.

Claim 15

A method according to claim 1 wherein the container has a total volume of approximately in a range of 1 to 1000 milliliters.

Claim 16

A method according to claim 1 wherein the container comprises a generally tubular glass vial.

Claim 17

A method according to claim 15 wherein the glass vial is molded.

Claim 18

A method according to claim 1 wherein the container comprises a glass vial and the first fluid is a parenteral drug.

Claim 19

A non-destructive fill volume measurement system for determining a volume of a first fluid in a sealed container, the container also containing a second fluid having a lower density than the first fluid, comprising: means for holding a container in a selected position, the container having a generally symmetrical shape defining a central longitudinal axis; means for measuring an upright fluid level while the container is upright and for measuring an inverted fluid level while the container is inverted; means for determining a common volume of the container intermediate the upright and inverted fluid levels; means coupled to the holding means for rotating the container about a selected axis of rotation normal to the longitudinal axis and substantially centered through the container so as to force the contents of the vial away from said axis of rotation, whereby the second fluid forms a substantially stable, generally cylindrical pocket about the said axis of rotation; means for determining a volume of the pocket while the container is rotating; and means for determining a volume of the first fluid as a sum of the common volume and the pocket volume.

Claim 20

A non-destructive fill volume measurement system for determining a volume of a first fluid in a sealed container, the container also containing a second fluid having a lower density than the first fluid, comprising: means for holding a container in a selected position, the container having a generally symmetrical shape defining a central longitudinal axis; means for measuring an upright fluid level while the container is upright and for measuring an inverted fluid level while the container is inverted; means for determining a common volume of the container intermediate the upright and inverted fluid levels; means coupled to the holding means for rotating the container about a selected axis of rotation normal to the longitudinal axis and substantially centered through the container so as to force the contents of the vial away from said axis of rotation, whereby the second fluid forms a substantially stable, generally cylindrical pocket about the said axis of rotation; means for determining a volume of the pocket while the container is rotating; and means for determining a volume of the first fluid as a sum of the common volume and the pocket volume.

Claim 21

A volume measurement system according to claim 18 wherein the means for measuring the upright and inverted fluid levels includes a machine vision means for capturing and processing images of the container.

Claim 22

A volume measurement system according to claim 18 wherein the means for determining a volume of the pocket includes machine vision means for capturing and processing images of the container while the container is rotating.

Claim 23

A volume measurement system according to claim 20 further comprising lighting means arranged for illuminating the container in support of the machine vision means.

Claim 24

A volume measurement system according to claim 21 wherein the lighting means includes an infrared light source.

Claim 25

A volume measurement system according to claim 22 wherein the infrared light source includes an array of infrared light-emitting diodes and a diffusion panel overlying the array.

Claim 26

A non-destructive liquid fill volume measurement system for determining a volume of a liquid in a sealed container, the container also containing air, the system comprising: centrifuge means for holding and rotating a container about a predetermined axis of rotation that extends through the container; and machine vision means for capturing and processing an image of at least a central portion of a container mounted in the centrifuge means, the machine vision means including a camera alignable along the said axis of rotation for forming said image of the container.

Claim 27

A non-destructive liquid fill volume measurement system for determining a volume of a liquid in a sealed container, the container also containing air, the system comprising: centrifuge means for holding and rotating a container about a predetermined axis of rotation that extends through the container; and machine vision means for capturing and processing an image of at least a central portion of a container mounted in the centrifuge means, the machine vision means including a camera alignable along the said axis of rotation for forming said image of the container.

Claim 28

A volume measurement system according to claim 24 further comprising image processing means for measuring an air pocket formed in the container while the container is rotating by gauging the said image.

Claim 29

A volume measurement system according to claim 25 further comprising a light source arranged so as to direct light through the container toward the camera.

Claim 30

A volume measurement system according to claim 26 wherein the light source includes an infrared light source and further comprising means disposed in front of the camera for filtering visible light, so that the said image is formed responsive only to light provided by the infrared light source.

Claim 31

A volume measurement system according to claim 27 wherein the infrared light source includes an array of infrared light-emitting diodes and a diffusion panel overlying the array so as to diffuse hot spots.

Claim 32

A volume measurement system according to claim 24 wherein the centrifuge means includes a centrifuge housing, a centrifuge spindle rotatably disposed in the centrifuge housing and a motor operatively coupled to the centrifuge spindle for rotating the spindle and thereby rotating the container.

Claim 33

A volume measurement system according to claim 29 further comprising a motor controller for controlling the motor, and wherein the motor comprises a selected one of a stepper motor and a servo motor.