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US5565439A
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Methods of using lysophosphatidic acid for treating hyperproliferative conditions
Assignee: Procter and Gamble Co
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Filing: 1994-11-04
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Granted: 1996-10-15
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Expires: 2014-11-04
Abstract
Abstract The subject invention involves a method for treating hyperproliferative conditions in mammalian epithelial cells comprising administering to the mammal a composition containing a safe and effective amount of a lysophosphatidic acid compound or derivative having the structure <IMAGE> or a cyclic derivative thereof having the structure <IMAGE> or a pharmaceutically acceptable salt thereof, wherein: a) -Y- is -0- or -CH2-; b) -Z is -XH, -H or halo; c) each -X- is independently -0- or -S-; and d) -R is unsubstituted or substituted, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms.
Inventors
- 👤 Gary A. Piazza
- 👤 Adam W. Mazur
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 20:18
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/66; A61K31/661; A61K31/662; A61K31/665
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
118 words
A method of inhibiting benign epithelial cell proliferation in mammalian cells comprising administering to a human or lower animal susceptible to or having said epithelial cell proliferation a safe and effective amount of a lysophosphatidic acid compound having the structure: ##STR8## or a cyclic derivative thereof having the structure: ##STR9## or a pharmaceutically acceptable salt thereof, wherein: a) --Y-- is --0-- or --CH 2 ; b) --Z is --XH, --H or halo; c) each --X-- is independently --0-- or --S--; and d) --R is unsubstituted or substituted with a substituent selected from the group consisting of halogen, hydroxy, phenyl, amino and acylamino, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms.
Claim 2
Independent Claim
118 words
A method of inhibiting benign epithelial cell proliferation in mammalian cells comprising administering to a human or lower animal susceptible to or having said epithelial cell proliferation a safe and effective amount of a lysophosphatidic acid compound having the structure: ##STR8## or a cyclic derivative thereof having the structure: ##STR9## or a pharmaceutically acceptable salt thereof, wherein: a) --Y-- is --0-- or --CH 2 ; b) --Z is --XH, --H or halo; c) each --X-- is independently --0-- or --S--; and d) --R is unsubstituted or substituted with a substituent selected from the group consisting of halogen, hydroxy, phenyl, amino and acylamino, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms.
Claim 3
Dependent Claim
21 words
The method of claim 1 wherein the hyperproliferative condition is psoriasis, and --R has from 13 to about 19 carbon atoms.
Claim 4
Dependent Claim
22 words
The method of claim 1 wherein the condition being treated is psoriasis, and --R has from 13 to about 19 carbon atoms.
Claim 5
Dependent Claim
17 words
The method of claim 1 wherein the lysophosphatidic acid compound is applied topically to the mammalian skin.
Claim 6
Dependent Claim
40 words
The method of claim 4 wherein the amount of lysophosphatidic acid compound applied is from about 0.01 mg per cm 2 skin to about 1 mg per cm 2 skin, and --R has from 13 to about 19 carbon atoms.
Claim 7
Dependent Claim
15 words
The method of claim 1 wherein the composition is administered in an injectable dose form.
Claim 8
Dependent Claim
15 words
The method of claim 1 wherein the composition is administered in an oral dose form.
References Cited (Backward Citations)
JPS5528955A
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US4876381A
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JPS61183207A
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JPS62225240A
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JPH02138132A
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JPH0366604A
Cited
JPH0374316A
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JPH03161414A
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JPH06325342A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-10-15 | 2000-04-15 | 2000-10-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-10-15 | 2004-04-15 | 2004-10-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-10-15 | 2008-04-15 | 2008-10-15 | $7700.00 | Window Closed / Lapsed |