US5565439A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods of using lysophosphatidic acid for treating hyperproliferative conditions
Assignee: Procter and Gamble Co
•
Filing: 1994-11-04
•
Granted: 1996-10-15
•
Expires: 2014-11-04
Abstract
Abstract The subject invention involves a method for treating hyperproliferative conditions in mammalian epithelial cells comprising administering to the mammal a composition containing a safe and effective amount of a lysophosphatidic acid compound or derivative having the structure <IMAGE> or a cyclic derivative thereof having the structure <IMAGE> or a pharmaceutically acceptable salt thereof, wherein: a) -Y- is -0- or -CH2-; b) -Z is -XH, -H or halo; c) each -X- is independently -0- or -S-; and d) -R is unsubstituted or substituted, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms.
Inventors
- 👤 Gary A. Piazza
- 👤 Adam W. Mazur
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 19:46
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/66; A61K31/661; A61K31/662; A61K31/665
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
118 words
A method of inhibiting benign epithelial cell proliferation in mammalian cells comprising administering to a human or lower animal susceptible to or having said epithelial cell proliferation a safe and effective amount of a lysophosphatidic acid compound having the structure: ##STR8## or a cyclic derivative thereof having the structure: ##STR9## or a pharmaceutically acceptable salt thereof, wherein: a) --Y-- is --0-- or --CH 2 ; b) --Z is --XH, --H or halo; c) each --X-- is independently --0-- or --S--; and d) --R is unsubstituted or substituted with a substituent selected from the group consisting of halogen, hydroxy, phenyl, amino and acylamino, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms.
Claim 2
Independent Claim
118 words
A method of inhibiting benign epithelial cell proliferation in mammalian cells comprising administering to a human or lower animal susceptible to or having said epithelial cell proliferation a safe and effective amount of a lysophosphatidic acid compound having the structure: ##STR8## or a cyclic derivative thereof having the structure: ##STR9## or a pharmaceutically acceptable salt thereof, wherein: a) --Y-- is --0-- or --CH 2 ; b) --Z is --XH, --H or halo; c) each --X-- is independently --0-- or --S--; and d) --R is unsubstituted or substituted with a substituent selected from the group consisting of halogen, hydroxy, phenyl, amino and acylamino, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms.
Claim 3
Dependent Claim
21 words
The method of claim 1 wherein the hyperproliferative condition is psoriasis, and --R has from 13 to about 19 carbon atoms.
Claim 4
Dependent Claim
22 words
The method of claim 1 wherein the condition being treated is psoriasis, and --R has from 13 to about 19 carbon atoms.
Claim 5
Dependent Claim
17 words
The method of claim 1 wherein the lysophosphatidic acid compound is applied topically to the mammalian skin.
Claim 6
Dependent Claim
40 words
The method of claim 4 wherein the amount of lysophosphatidic acid compound applied is from about 0.01 mg per cm 2 skin to about 1 mg per cm 2 skin, and --R has from 13 to about 19 carbon atoms.
Claim 7
Dependent Claim
15 words
The method of claim 1 wherein the composition is administered in an injectable dose form.
Claim 8
Dependent Claim
15 words
The method of claim 1 wherein the composition is administered in an oral dose form.
References Cited (Backward Citations)
JPS5528955A
Cited
US4876381A
Cited
JPS61183207A
Cited
JPS62225240A
Cited
JPH02138132A
Cited
JPH0366604A
Cited
JPH0374316A
Cited
JPH03161414A
Cited
JPH06325342A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-10-15 | 2000-04-15 | 2000-10-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-10-15 | 2004-04-15 | 2004-10-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-10-15 | 2008-04-15 | 2008-10-15 | $7700.00 | Window Closed / Lapsed |