Abstract This invention encompasses methods for the inhibition of Alzheimer's Disease comprising administering to a human in need thereof an effective amount of a compound of Formula I ##STR1## wherein R 1 and R 3 are independently hydrogen, ##STR2## wherein Ar is optionally substituted phenyl; R 2 is selected from the group consisting of pyrrolidine, hexamethylenemino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof. The present invention also provides methods of increasing TGF-β expression in the brain, comprising administering to a human in need thereof an effective amount of a compound of formula 1. The present invention also provides methods of inhibiting the β-amyloid peptide mediated neurotoxicity or inflammatory response associated with Alzheimer's Disease (AD) comprising administering to a human in need thereof an effective amount of a compound of formula 1.
A method of increasing TGF-β expression in the brain comprising administering to a human in need thereof an effective amount of a compound of Formula I ##STR6## wherein R 1 and R 3 are independently hydrogen, ##STR7## wherein Ar is optionally substituted phenyl; R 2 is selected from the group consisting of hexamethylenemino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.
Claim 2
Independent Claim
63 words
A method of increasing TGF-β expression in the brain comprising administering to a human in need thereof an effective amount of a compound of Formula I ##STR6## wherein R 1 and R 3 are independently hydrogen, ##STR7## wherein Ar is optionally substituted phenyl; R 2 is selected from the group consisting of hexamethylenemino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.
Claim 3
Dependent Claim
10 words
The method of claim 1, wherein said administration is prophylactic.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein said human is a post-menopausal female.
Claim 5
Dependent Claim
13 words
The method of claim 1 wherein said compound ##STR8## or its hydrochloride salt.