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US5545531A
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Methods for making a device for concurrently processing multiple biological chip assays
Assignee: Affymetrix Inc
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Filing: 1995-06-07
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Granted: 1996-08-13
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Expires: 2015-06-07
Abstract
Abstract Methods for concurrently processing multiple biological chip assays by providing a biological chip plate comprising a plurality of test wells, each test well having a biological chip having a molecular probe array; introducing samples into the test wells; subjecting the biological chip plate to manipulation by a fluid handling device that automatically performs steps to carry out reactions between target molecules in the samples and probes; and subjecting the biological chip plate to a biological chip plate reader that interrogates the probe arrays to detect any reactions between target molecules and probes.
Inventors
- 👤 Richard P. Rava
- 👤 Stephen P. A. Fodor
- 👤 Mark Trulson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 05:16
CPC Classifications
G; G01; G01N; G01N35/00; G01N35/02; G01N35/028; B; B01; B01J; B01J19/00; B01J19/0046; B01L; B01L3/00; B01L3/50; B01L3/508; B01L3/5085; C; C12; C12Q; C12Q1/00; C12Q1/68; C12Q1/6813; C12Q1/6834; C12Q1/6837; B01J2219/00; B01J2219/00274; B01J2219/00277; B01J2219/00279; B01J2219/00306; B01J2219/00313; B01J2219/00315; B01J2219/00317; B01J2219/00351; B01J2219/00427; B01J2219/00432; B01J2219/00497; B01J2219/00527; B01J2219/00529; B01J2219/00583; B01J2219/00603; B01J2219/00605; B01J2219/00608; B01J2219/0061; B01J2219/00612; B01J2219/00614; B01J2219/00617; B01J2219/00621; B01J2219/00623; B01J2219/00626; B01J2219/00632; B01J2219/00637; B01J2219/00659; B01J2219/00662; B01J2219/0068; B01J2219/00702; B01J2219/00707; B01J2219/00718; B01J2219/0072; B01J2219/00722; B01L2300/00; B01L2300/06; B01L2300/0627; B01L2300/0636; B01L2300/08; B01L2300/0809; B01L2300/0829; C40; C40B; C40B40/00; C40B40/04; C40B40/06; C40B60/00; C40B60/14; G01N21/00; G01N21/62; G01N21/63; G01N21/64
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
80 words
A method for making a biological chip plate comprising the steps of: (a) providing a body comprising a plurality of wells defining spaces; (b) providing a wafer comprising on its surface a plurality of probe arrays, each probe array comprising a collection of probes, at least two of which are different, arranged in a spacially defined and physically addressable manner; (c) attaching the wafer to the body so that the probe arrays are exposed to the spaces of the wells.
Claim 2
Independent Claim
80 words
A method for making a biological chip plate comprising the steps of: (a) providing a body comprising a plurality of wells defining spaces; (b) providing a wafer comprising on its surface a plurality of probe arrays, each probe array comprising a collection of probes, at least two of which are different, arranged in a spacially defined and physically addressable manner; (c) attaching the wafer to the body so that the probe arrays are exposed to the spaces of the wells.
Claim 3
Dependent Claim
13 words
The method of claim 1 wherein the probes are DNA or RNA molecules.
Claim 4
Independent Claim
71 words
A method for making a biological chip plate comprising the steps of providing a wafer comprising on its surface a plurality of probe arrays, each probe array comprising a collection of probes, at least two of which are different, arranged in a spacially defined and physically addressable manner; and applying a material resistant to the flow of a liquid sample so as to surround the probe arrays, thereby creating test wells.
Claim 5
Independent Claim
71 words
A method for making a biological chip plate comprising the steps of providing a wafer comprising on its surface a plurality of probe arrays, each probe array comprising a collection of probes, at least two of which are different, arranged in a spacially defined and physically addressable manner; and applying a material resistant to the flow of a liquid sample so as to surround the probe arrays, thereby creating test wells.
Claim 6
Dependent Claim
13 words
The method of claim 3 wherein the probes are DNA or RNA molecules.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-08-13 | 2000-02-12 | 2000-08-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-08-13 | 2004-02-12 | 2004-08-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-08-13 | 2008-02-12 | 2008-08-13 | $7700.00 | Window Closed / Lapsed |