Patent US5545402A successfully refreshed from Google Patents.
US5545402A
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Skin care method and composition
Assignee: Elizabeth Arden Inc
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Filing: 1994-09-12
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Granted: 1996-08-13
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Expires: 2014-09-12
Abstract
Abstract A composition for topical application to the skin for alleviation or prevention of dry flaky skin condition, dandruff or acne comprising one or more stratum corneum thiol proteases. The composition may further comprise a mild reducing agent and/or an additional enzyme selected from glycosidases, other proteases, lipases and mixtures thereof. Optional additional active ingredients include sunscreens, lipids, hydroxy carboxylic acids and ketocarboxylic acids.
Inventors
- 👤 Allan Watkinson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 15:54
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/64; A61K8/66; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K38/48; A61K38/4873; A61Q; A61Q19/00; A61Q19/007; A61Q5/00; A61Q5/006; C; C12; C12N; C12N9/00; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6472
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
88 words
A topical composition comprising (i) a stratum corneum thiol cysteine protease which in its active form is inhibited by E64 and has an apparent molecular weight of 34 or 35 kDa when determined by sodium dodecyl sulphate polyacrylamide gel electrophoresis as herein described; and (ii) a mild reducing agent selected from the group consisting of sulphides, thiol-containing compositions including dithiothreitol, trithiohexitol, cysteine or protein hydrolysates rich in cysteine, N-acetyl-cysteine, mercaptoethanol, thioglycerol. mercaptosuccinic acid, thiolactic acid and their salts, thioglycollic acid and salts of thioglycollic acid and mixtures thereof.
Claim 2
Dependent Claim
88 words
A topical composition comprising (i) a stratum corneum thiol cysteine protease which in its active form is inhibited by E64 and has an apparent molecular weight of 34 or 35 kDa when determined by sodium dodecyl sulphate polyacrylamide gel electrophoresis as herein described; and (ii) a mild reducing agent selected from the group consisting of sulphides, thiol-containing compositions including dithiothreitol, trithiohexitol, cysteine or protein hydrolysates rich in cysteine, N-acetyl-cysteine, mercaptoethanol, thioglycerol. mercaptosuccinic acid, thiolactic acid and their salts, thioglycollic acid and salts of thioglycollic acid and mixtures thereof.
Claim 3
Dependent Claim
27 words
A composition according to claim 1 wherein the stratum corneum thiol protease is present in an amount of from 0.00001 to 50% by weight of the composition.
Claim 4
Dependent Claim
15 words
A composition according to claim 1 wherein the mild reducing agent comprises a thiol-containing compound.
Claim 5
Dependent Claim
12 words
A composition according to claim 1 wherein the reducing agent is cysteine.
Claim 6
Dependent Claim
25 words
A composition according to claim 1 wherein the reducing agent is present in an amount of from 0.00001 to 15% by weight of the composition.
Claim 7
Dependent Claim
19 words
A composition according to claim 1 further comprising an enzyme selected from glycosidases, other proteases, lipases and mixtures thereof.
Claim 8
Dependent Claim
34 words
A composition according to claim 1 further comprising one or more ingredients selected from sunscreens, hydroxycarboxylic acids, ketocarboxylic acids, ceramides, pseudoceramides, polyol fatty acid polyesters, sterols, phospholipids, galactosyldiacylglycerols, glycosphingolipids, fatty acids or esters thereof.
Claim 9
Independent Claim
108 words
A method of relieving or ameliorating dry skin conditions, acne and dandruff which includes the topical application to the skin of a composition comprising (i) a stratum corneum thiol cysteine protease which in its active form is inhibited by E64 and has an apparent molecular weight of 34 or 35 kDa when determined by sodium dodecyl sulphate polyacrylamide gel electrophoresis as herein described; and (ii) a mild reducing agent selected from the group consisting of sulphides, thiol-containing compositions including dithiothreitol, trithiohexitol, cysteine or protein hydrolysates rich in cysteine, N-acetyl-cysteine, mercaptoethanol, thioglycerol, mercaptosuccinic acid, thiolactic acid and their salts, thioglycollic acid and salts of thioglycollic acid and mixtures thereof.
Claim 10
Independent Claim
108 words
A method of relieving or ameliorating dry skin conditions, acne and dandruff which includes the topical application to the skin of a composition comprising (i) a stratum corneum thiol cysteine protease which in its active form is inhibited by E64 and has an apparent molecular weight of 34 or 35 kDa when determined by sodium dodecyl sulphate polyacrylamide gel electrophoresis as herein described; and (ii) a mild reducing agent selected from the group consisting of sulphides, thiol-containing compositions including dithiothreitol, trithiohexitol, cysteine or protein hydrolysates rich in cysteine, N-acetyl-cysteine, mercaptoethanol, thioglycerol, mercaptosuccinic acid, thiolactic acid and their salts, thioglycollic acid and salts of thioglycollic acid and mixtures thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-08-13 | 2000-02-12 | 2000-08-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-08-13 | 2004-02-12 | 2004-08-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-08-13 | 2008-02-12 | 2008-08-13 | $7700.00 | Window Closed / Lapsed |