Composition compatible with blood

Claim 2

A composition compatible with blood prepared by ion exchange complexation of a polymer having quaternary ammonium groups with an alkali metal salt of a polyanion selected from the group consisting of heparin, chondroitin sulfate, dextran sulfate, and polyvinyl alcohol sulfate, wherein said polymer having quaternary ammonium groups is prepared by quaternizing a polymer containing tertiary amino groups with a quaternizing agent, and wherein the equivalent ratio, M/S, of alkali metal atoms (M) to sulfur atoms (S) in the composition is 0.4 or less.

Claim 3

A composition compatible with blood according to claim 1, wherein the polymer having quaternary ammonium groups is a polyurethane or polyurethaneurea having quaternary ammonium groups obtained by quaternizing the tertiary amino groups of a polyurethane or polyurethaneurea, wherein the polyurethane or the polyurethaneurea is obtained by reacting a polyaminoetherpolyol that has at least two functional groups that react with isocyanato groups with a polyisocyanate, and wherein the polyaminoetherpolyol is obtained by condensation of diols containing at least 30 mol % amino alcohol represented by a structure selected from the group consisting of ##STR7## wherein R 2 is an alkyl group having 1 to 15 carbon atoms.

Claim 4

A composition compatible with blood according to claim 1, wherein the polymer having quaternary ammonium groups is a polyurethane or polyurethaneurea having quaternary ammonium groups obtained by quaternizing at least a part of the tertiary amino groups in a polyurethane or polyurethaneurea with an alkyl halide or an active ester, wherein the polyurethane or the polyurethaneurea is prepared by reacting a diisocyanate, a polysiloxane having a hydroxyl group or an amino group at one or more of its molecular termini, and a polyaminoetherpolyol having tertiary amino groups.

Claim 5

A composition compatible with blood according to claim 1, wherein the polymer having quaternary ammonium groups contains either a polyurethane or a polyurethaneurea having quaternary ammonium groups, and a polytetramethylene glycol.

Claim 6

A composition compatible with blood according to claim 2, wherein the total number of carbon atoms of two side chains bonded to a quaternary nitrogen atom of a polymer having quaternary ammonium groups is 5 to 16, in which one chain is bonded to a tertiary nitrogen atom of the polymer having tertiary amino groups and the other side chain is derived from the quaternizing agent.

Claim 7

A composition compatible with blood according to claim 1, wherein the ion exchange complexation is carried out in a mixed solvent of a water-soluble organic solvent and water.

Claim 8

A composition compatible with blood obtained by ion exchange complexation of a polymer having quaternary ammonium groups with an alkali metal salt of a polyanion selected from the group consisting of heparin, chondroitin sulfate, dextran sulfate, and polyvinyl alcohol sulfate, wherein the polymer is a polyurethane or a polyurethaneurea obtained by quaternizing at least a part of the tertiary amino groups in the polymer with an alkyl halide having 1 to 10 carbon atoms, wherein the polyurethane or the polyurethaneurea is obtained by reacting a polyaminoetherpolyol that has at least two functional groups that react with isocyanato groups with a polyisocyanate, and wherein the polyaminoetherpolyol contains, as a diol component, at least 30 mol % of an amino alcohol represented by the structure ##STR8## wherein R 1 and R 3 are independently alkyl groups with 1 to 5 carbon atoms, and R 2 is an alkyl groups with 1 to 15 carbon atoms, an aralkyl group with 7 to 15 carbon atoms, or an aryl group with 6 to 15 carbon atoms, wherein the total number of carbon atoms of two side chains bonded to a quaternary nitrogen atom of a polymer having quaternary ammonium groups is 5 to 16, in which one chain is bonded to a tertiary nitrogen atom of the polymer having tertiary amino groups and the other side chain is derived from the quaternizing agent, and wherein the equivalent ratio, M/S, of alkali metal atoms (H) to sulfur atoms (S) in the composition is 0.4 or less.

Claim 9

A composition compatible with blood obtained by ion exchange complexation of a polymer having quaternary ammonium groups with an alkali metal salt of a polyanion selected from the group consisting of heparin, chondroitin sulfate, dextran sulfate, and polyvinyl alcohol sulfate, wherein the polymer is a polyurethane or a polyurethaneurea obtained by quaternizing at least a part of the tertiary amino groups in the polymer with an alkyl halide having 1 to 10 carbon atoms, wherein the polyurethane or the polyurethaneurea is obtained by reacting a polyaminoetherpolyol that has at least two functional groups that react with isocyanato groups with a polyisocyanate, and wherein the polyaminoetherpolyol contains, as a diol component, at least 30 mol % of an amino alcohol represented by the structure ##STR8## wherein R 1 and R 3 are independently alkyl groups with 1 to 5 carbon atoms, and R 2 is an alkyl groups with 1 to 15 carbon atoms, an aralkyl group with 7 to 15 carbon atoms, or an aryl group with 6 to 15 carbon atoms, wherein the total number of carbon atoms of two side chains bonded to a quaternary nitrogen atom of a polymer having quaternary ammonium groups is 5 to 16, in which one chain is bonded to a tertiary nitrogen atom of the polymer having tertiary amino groups and the other side chain is derived from the quaternizing agent, and wherein the equivalent ratio, M/S, of alkali metal atoms (H) to sulfur atoms (S) in the composition is 0.4 or less.

Claim 10

A composition compatible with blood according to claim 7, wherein the alkyl halide has 2 to 8 carbon atoms.

Claim 11

A composition compatible with blood according to claim 7, wherein the total number of carbon atoms of said two side chains bonded to a quaternary nitrogen atom of a polymer having quaternary ammonium groups is 6 to 14.

Claim 12

A composition compatible with blood according to claim 7, wherein the polyaminoetherpolyol has a molecular weight of from 200 to 8,000.

Claim 13

A composition compatible with blood according to claim 7, wherein the polyaminoetherpolyol has a molecular weight of from 500 to 4,000.

Claim 14

A composition compatible with blood according to claim 7, wherein the tertiary amino groups of the polyaminoetherpolyol precursor of the polyurethane or the polyurethaneurea are present in an amount of 0.05 to 5.00 mmol/g.

Claim 15

A composition compatible with blood according to claim 7, wherein the tertiary amino groups of the polyaminoetherpolyol precursor of the polyurethane or the polyurethaneurea are present in an amount of 0.1 to 3.0 mmol/g.

Claim 16

A composition compatible with blood according to claim 7, wherein 10% or more of the tertiary amino groups are quaternized.

Claim 17

A composition compatible with blood according to claim 7, wherein 20% or more of the tertiary amino groups are quaternized.

Claim 18

A composition compatible with blood according to claim 7, wherein the alkali metal salt of heparin is selected from the group consisting of a sodium salt of heparin and a potassium salt of heparin.

Claim 19

A composition compatible with blood according to claim 7, wherein the ion exchange complexation is carried out in a mixed solvent of a water-soluble organic solvent and water.

Claim 20

A composition compatible with blood according to claim 17, wherein the water-soluble organic solvent is tetrahydrofuran, and the ratio of the water to the tetrahydrofuran is from 20/1 to 3/7.

Claim 21

A composition compatible with blood according to claim 18, wherein the ratio of the water to the tetrahydrofuran is from 10/1 to 3/5.

Claim 22

A composition compatible with blood according to claim 1, wherein the polymer having quaternary ammonium groups is a film.

Claim 23

A composition compatible with blood according to claim 7, wherein the polymer having quaternary ammonium groups is a film.