US5539082A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Peptide nucleic acids
Assignee: Individual
•
Filing: 1993-04-26
•
Granted: 1996-07-23
•
Expires: 2013-04-26
Abstract
Abstract A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
Inventors
- 👤 Peter E. Nielsen
- 👤 Ole Buchardt
- 👤 Michael Egholm
- 👤 Rolf H. Berg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 22:48
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/11; C12N15/113; A; A61; A61P; A61P31/00; A61P31/12; A61P35/00; B; B82; B82Y; B82Y5/00; C07; C07H; C07H21/00; C07K; C07K14/00; C07K14/001; C07K14/003; C07K5/00; C07K5/04; C07K5/06; C07K5/06008; C07K5/06017; C07K5/06026; C07K7/00; C07K7/04; C07K7/06; C07K7/08; C12Q; C12Q1/00; C12Q1/68; C12Q1/6813; C12Q1/6869; A61K; A61K38/00; C12N2310/00; C12N2310/10; C12N2310/15; C12N2310/30; C12N2310/31; C12N2310/318; C12N2310/3181
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
130 words
A compound having the formula: ##STR8## wherein: each L is independently selected from the group consisting of hydrogen, phenyl, heterocyclic moleties, naturally occurring nucleobases, and non-naturally occurring nucleobases; each R 3 is independently selected from the group consisting of hydrogen, (C 1 -C 4 )alkyl, hydroxy- or alkoxy- or alkylthio-substituted (C 1 -C 4 )alkyl, hydroxy, alkoxy, alkylthio and amino; each R 7' is independently selected from the group consisting of hydrogen and the side chains of naturally occurring alpha amino acids; n is an integer from 1 to 60, each k, l, and m is, independently, zero or an integer from 1 to 5; each p is zero or 1; R h is OH, NH 2 or --NHLysNH 2 ; and R i is H or COCH 3 .
Claim 2
Dependent Claim
130 words
A compound having the formula: ##STR8## wherein: each L is independently selected from the group consisting of hydrogen, phenyl, heterocyclic moleties, naturally occurring nucleobases, and non-naturally occurring nucleobases; each R 3 is independently selected from the group consisting of hydrogen, (C 1 -C 4 )alkyl, hydroxy- or alkoxy- or alkylthio-substituted (C 1 -C 4 )alkyl, hydroxy, alkoxy, alkylthio and amino; each R 7' is independently selected from the group consisting of hydrogen and the side chains of naturally occurring alpha amino acids; n is an integer from 1 to 60, each k, l, and m is, independently, zero or an integer from 1 to 5; each p is zero or 1; R h is OH, NH 2 or --NHLysNH 2 ; and R i is H or COCH 3 .
Claim 3
Dependent Claim
130 words
A compound having the formula: ##STR9## wherein: each L is independently selected from the group consisting of hydrogen, phenyl, heterocyclic moieties, naturally occurring nucleobases, and non-naturally occurring nucleobases; each R 3 is independently selected from the group consisting of hydrogen, (C 1 -C 4 )alkyl, hydroxy- or alkoxy- or alkylthio-substituted (C 1 -C 4 )alkyl, hydroxy, alkoxy, alkylthio and amino; each R 7' is independently selected from the group consisting of hydrogen and the side chains of naturally occurring alpha amino acids; n is an integer from 1 to 60, each k, l, and m is, independently, zero or an integer from 1 to 5; each p is zero or 1; R h is OH, NH 2 or --NHLysNH 2 ; and R i is H or COCH 3 .
Claim 4
Dependent Claim
130 words
A compound having the formula: ##STR9## wherein: each L is independently selected from the group consisting of hydrogen, phenyl, heterocyclic moieties, naturally occurring nucleobases, and non-naturally occurring nucleobases; each R 3 is independently selected from the group consisting of hydrogen, (C 1 -C 4 )alkyl, hydroxy- or alkoxy- or alkylthio-substituted (C 1 -C 4 )alkyl, hydroxy, alkoxy, alkylthio and amino; each R 7' is independently selected from the group consisting of hydrogen and the side chains of naturally occurring alpha amino acids; n is an integer from 1 to 60, each k, l, and m is, independently, zero or an integer from 1 to 5; each p is zero or 1; R h is OH, NH 2 or --NHLysNH 2 ; and R i is H or COCH 3 .
Claim 5
Dependent Claim
100 words
A compound having the formula: ##STR10## wherein: L is independently selected from the group consisting of hydrogen, phenyl, heterocyclic moieties, naturally occurring nucleobases, and non-naturally occurring nucleobases; R 3 is selected from the group consisting of hydrogen, (C 1 -C 4 ) alkyl, hydroxy- or alkoxy- or alkylthio-substituted (C 1 -C 4 ) alkyl, hydroxy, alkylthio and amino; each R 7' is independently selected from the group consisting of hydrogen and the side chains of naturally occurring alpha amino acids; k, l, and m are, independently, zero or an integer from 1 to 5; and p is zero or 1.
Claim 6
Dependent Claim
100 words
A compound having the formula: ##STR10## wherein: L is independently selected from the group consisting of hydrogen, phenyl, heterocyclic moieties, naturally occurring nucleobases, and non-naturally occurring nucleobases; R 3 is selected from the group consisting of hydrogen, (C 1 -C 4 ) alkyl, hydroxy- or alkoxy- or alkylthio-substituted (C 1 -C 4 ) alkyl, hydroxy, alkylthio and amino; each R 7' is independently selected from the group consisting of hydrogen and the side chains of naturally occurring alpha amino acids; k, l, and m are, independently, zero or an integer from 1 to 5; and p is zero or 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-07-23 | 2000-01-22 | 2000-07-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-07-23 | 2004-01-22 | 2004-07-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-07-23 | 2008-01-22 | 2008-07-23 | $7700.00 | Window Closed / Lapsed |