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US5142047A Expired / Lapsed US ⏱️ 0.0 years remaining

Uncharged polynucleotide-binding polymers

Assignee: Anti Gene Development Group LP
•
Filing: 1987-09-23
•
Granted: 1992-08-25
•
Expires: 2007-09-23
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Abstract

Abstract A composition of polymer molecules effective to bind, with substantially uniform binding affinity, to a single-stranded polynucleotide containing a target sequence of bases. The polymer molecules are composed of a sequence of base-pairing moieties effective to hydrogen bond to corresponding, complementary bases in the target sequence, under selected binding conditions, and a predominantly uncharged, achiral backbone supporting the base-pairing moieties at positions and in orientations which allow hydrogen bonding between the pairing moieties of the polymer and the corresponding complementary bases in the target sequence. The composition has diagnostic uses, in a solid-support assay system, and therapeutic uses involving inhibition or inactivation of target polynucleotides.

Inventors

  • 👤 James Summerton
  • 👤 Dwight Weller
  • 👤 Eugene Stirchak

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-30 21:17
CPC Classifications
C; C07; C07H; C07H21/00; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/54; A61K47/545; A61K47/548; A61K47/56; A61K47/58; A61K47/59; C07K; C07K14/00; C07K14/001; C07K14/003; C12; C12Q; C12Q1/00; C12Q1/68; C12Q1/6813; C12Q1/6816; C12Q1/682; C12Q1/6839; B; B01; B01J; B01J2219/00; B01J2219/00274; B01J2219/00718; B01J2219/0072; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55

Claims Analysis

Total Claims: 4
Claim 1
Independent Claim 55 words
A morpholino subunit of the form: ##STR4## where P is a base-pairing moiety capable of binding by Watson/Crick pairing to complementary bases in a polynucleotide, and where P is selected from the group consisting of: ##STR5## where X=F, Cl, Br, I, H, or CH 3 , and ##STR6## T is H or an N-protective group.
Claim 2
Dependent Claim 55 words
A morpholino subunit of the form: ##STR4## where P is a base-pairing moiety capable of binding by Watson/Crick pairing to complementary bases in a polynucleotide, and where P is selected from the group consisting of: ##STR5## where X=F, Cl, Br, I, H, or CH 3 , and ##STR6## T is H or an N-protective group.
Claim 3
Dependent Claim 61 words
A morpholino subunit of the form: ##STR7## where P is a base-pairing moiety capable of binding by Watson/Crick pairing to complementary bases in a polynucleotide, and where P is selected from the group consisting of: ##STR8## where X=F, Cl, Br, I, H, or CH 3 , and ##STR9## T 1 and T 2 are each either H or an N-protective group.
Claim 4
Dependent Claim 61 words
A morpholino subunit of the form: ##STR7## where P is a base-pairing moiety capable of binding by Watson/Crick pairing to complementary bases in a polynucleotide, and where P is selected from the group consisting of: ##STR8## where X=F, Cl, Br, I, H, or CH 3 , and ##STR9## T 1 and T 2 are each either H or an N-protective group.

References Cited (Backward Citations)

US3211732A Cited
US3225042A Cited
US3797414A Cited
US4558047A Cited
JPS62172384A Cited
JPH09118898A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1995-08-25 1996-02-24 1996-08-25 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1999-08-25 2000-02-24 2000-08-25 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2003-08-25 2004-02-24 2004-08-25 $7700.00 Window Closed / Lapsed

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