Patent US4038641A successfully refreshed from Google Patents.
Patent US5528652A successfully refreshed from Google Patents.
US5528652A
Expired / Lapsed
US
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Method for treating brain tumors
Assignee: Carl Zeiss AG
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Filing: 1994-08-05
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Granted: 1996-06-18
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Expires: 2014-08-05
Abstract
Abstract A method of treating brain tumors in a patient, comprising the steps of: identifying and locating a brain tumor in vivo; implanting at least a portion of an adjustable x-ray source in the patient proximate to the tumor, where the x-ray source generates an electron beam along a path on or slightly offset from a central axis to an x-ray emitting target element; and controlling the x-ray source to generate an x-ray pattern to selectively irradiate the tumor. Also disclosed is a method and apparatus for detecting certain x-ray photons generated by the x-ray source and propagating back on a path which is along or slightly off-set from the central axis of the implanted radiation source.
Inventors
- 👤 Donald O. Smith
- 👤 Mark T. Dinsmore
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:20
CPC Classifications
A; A61; A61N; A61N5/00; A61N5/10; A61N5/1001; H; H01; H01J; H01J35/00; H01J35/24; H01J35/30; H01J35/32; H05; H05G; H05G1/00; H05G1/02; H05G1/04; H05G1/06; H05G1/08; H05G1/10; H05G1/26; H05G1/30; H05G1/32; H05G1/34; A61N5/1002; A61N2005/1005; H01J2201/00; H01J2201/34; H01J2201/342
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
244 words
A method of treating brain minors in patient, comprising the steps of: A. identifying and locating a brain tumor in vivo; B. implanting at least a portion of a selectively operative x-ray source in said patient proximate to said tumor, said x-ray source including: i. a housing enclosing a beam generation means for generating an electron beam along a beam path; ii. an elongated tubular probe extending along a central axis from said housing and about said beam path, said beam path being along or slightly off-set from said central axis; iii. a target assembly including a target element and said means for coupling said target assembly to the end of said probe distal from said housing whereby said target element is positioned along said beam path, wherein said target element is responsive to electrons incident thereon to emit x-rays photons; and C. controlling the operation of said x-ray source to selectively irradiate said tumor, wherein said controlling step includes the substeps of: i. providing at least one x-ray photon detector affixed to said housing, ii. positioning said x-ray photon detector whereby said detector is responsive to x-ray photons propagating from said target element along or slightly off-set from said central axis to generate an x-ray photon signal representative of the incidence of an x-ray photon thereon, and iii. counting said x-ray photon signals and terminating the operation of said x-ray source when the number of counted x-ray photon signals matches a predetermined value.
Claim 2
Independent Claim
244 words
A method of treating brain minors in patient, comprising the steps of: A. identifying and locating a brain tumor in vivo; B. implanting at least a portion of a selectively operative x-ray source in said patient proximate to said tumor, said x-ray source including: i. a housing enclosing a beam generation means for generating an electron beam along a beam path; ii. an elongated tubular probe extending along a central axis from said housing and about said beam path, said beam path being along or slightly off-set from said central axis; iii. a target assembly including a target element and said means for coupling said target assembly to the end of said probe distal from said housing whereby said target element is positioned along said beam path, wherein said target element is responsive to electrons incident thereon to emit x-rays photons; and C. controlling the operation of said x-ray source to selectively irradiate said tumor, wherein said controlling step includes the substeps of: i. providing at least one x-ray photon detector affixed to said housing, ii. positioning said x-ray photon detector whereby said detector is responsive to x-ray photons propagating from said target element along or slightly off-set from said central axis to generate an x-ray photon signal representative of the incidence of an x-ray photon thereon, and iii. counting said x-ray photon signals and terminating the operation of said x-ray source when the number of counted x-ray photon signals matches a predetermined value.
Claim 3
Dependent Claim
18 words
The method of claim 1, wherein the x-ray photon detector is a scintillation detector located in said housing.
Claim 4
Dependent Claim
19 words
The method of claim 1, wherein the x-ray photon detector is a scintillation detector located outside of said housing.
Claim 5
Dependent Claim
181 words
A selectively operative x-ray source comprising, A. a housing enclosing a beam generation means for generating an electron beam along a beam path; B. an elongated tubular implantable probe extending along a central axis from said housing and about said beam path, said beam path being along or slightly off-set from said central axis; C. a target assembly including a target element and means for coupling said target assembly to the end of said probe distal from said housing whereby said target element is positioned along said beam path, wherein target element is responsive to electrons incident thereon to emit x-ray photons; and D. a radiation detection assembly affixed to said housing and positioned whereby said detection assembly is responsive to x-ray photons propagating from said target element along or slightly off-set from said central axis, to generate x-ray photon signals representative of the incidence of an x-ray photon signals thereon; E. a counter means for counting said x-ray photon signals and terminating the operation of said x-ray source when the number of counted x-ray photon signals matches a predetermined value.
Claim 6
Dependent Claim
181 words
A selectively operative x-ray source comprising, A. a housing enclosing a beam generation means for generating an electron beam along a beam path; B. an elongated tubular implantable probe extending along a central axis from said housing and about said beam path, said beam path being along or slightly off-set from said central axis; C. a target assembly including a target element and means for coupling said target assembly to the end of said probe distal from said housing whereby said target element is positioned along said beam path, wherein target element is responsive to electrons incident thereon to emit x-ray photons; and D. a radiation detection assembly affixed to said housing and positioned whereby said detection assembly is responsive to x-ray photons propagating from said target element along or slightly off-set from said central axis, to generate x-ray photon signals representative of the incidence of an x-ray photon signals thereon; E. a counter means for counting said x-ray photon signals and terminating the operation of said x-ray source when the number of counted x-ray photon signals matches a predetermined value.
Claim 7
Dependent Claim
17 words
The x-ray source according to claim 4, wherein said radiation detection assembly is located in said housing.
Claim 8
Dependent Claim
18 words
The x-ray source according to claim 4, wherein said radiation detection assembly is located outside of said housing.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-06-18 | 1999-12-18 | 2000-06-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-06-18 | 2003-12-18 | 2004-06-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-06-18 | 2007-12-18 | 2008-06-18 | $7700.00 | Window Closed / Lapsed |