Patent US5527864A successfully refreshed from Google Patents.
US5527864A
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Poly(propylene fumarate-co-ethylene oxide)
Assignee: Rice University
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Filing: 1995-08-08
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Granted: 1996-06-18
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Expires: 2015-08-08
Abstract
Abstract A biodegradable block copolymer made from the transesterfication of a poly(propylene fumarate) prepolymer and a poly(ethylene oxide) prepolymer. The block copolymer poly(propylene fumarate -co- ethylene oxide) is capable of crosslinking at body temperature. Crosslinking requires an appropriate crosslinking monomer and an initiator. The biodegradable block copolymer has utility as a vascular implant because it can be injected as a fluid into the vascular system and crosslinked in situ.
Inventors
- 👤 Laura J. Suggs
- 👤 Richard G. Payne
- 👤 Michael J. Yaszemski
- 👤 Antonios G. Mikos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:32
CPC Classifications
C; C08; C08G; C08G81/00; A; A61; A61K; A61K47/00; A61K47/50; A61K47/69; A61K47/6957; C08F; C08F283/00; C08F283/01; C08G63/00; C08G63/66; C08G63/668; C08G63/676; C08L; C08L71/00; C08L71/02
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
9 words
A block copolymer comprising poly(propylene fumarate -co- ethylene oxide).
Claim 2
Dependent Claim
9 words
A block copolymer comprising poly(propylene fumarate -co- ethylene oxide).
Claim 3
Dependent Claim
12 words
The block copolymer of claim 1 wherein the block copolymer is crosslinked.
Claim 4
Dependent Claim
17 words
The block copolymer of claim 2 wherein crosslinking will occur at a temperature of about 37° C.
Claim 5
Dependent Claim
22 words
The block copolymer of claim 1 wherein the copolymer has been crosslinked by addition polymerization at a temperature of about 37° C.
Claim 6
Dependent Claim
24 words
The block copolymer of claim 1 wherein the weight average molecular weight of the prepolymer poly(propylene fumarate) ranges from about 300 to about 12,000.
Claim 7
Dependent Claim
24 words
The block copolymer of claim 1 wherein the weight average molecular weight of the prepolymer poly(ethylene oxide) ranges from about 50 to about 20,000.
Claim 8
Dependent Claim
40 words
The block copolymer of claim 1 wherein the weight average molecular weight of the prepolymer poly(propylene fumarate) ranges from about 300 to about 12,000 and the molecular weight of the prepolymer poly(ethylene oxide) ranges from about 50 to about 20,000.
References Cited (Backward Citations)
US4888413A
Cited
US5213580A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-06-18 | 1999-12-18 | 2000-06-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-06-18 | 2003-12-18 | 2004-06-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-06-18 | 2007-12-18 | 2008-06-18 | $7700.00 | Window Closed / Lapsed |