US5519035A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of stroke or in anticipation of the occurrence of brain ischemia
Assignee: Cornell Research Foundation Inc
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Filing: 1993-07-02
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Granted: 1996-05-21
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Expires: 2013-07-02
Abstract
Abstract Administration of protein kinase C inhibitors protect neuronal cells from death from cerebral ischemia. Model for screening compounds for potential for protecting neuronal cells from death from cerebral ischemia comprises adding the compounds to medium containing neuronal cells before, at the same time as, and/or after nitric oxide administration.
Inventors
- 👤 Kenneth Maiese
- 👤 John A. Wagner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 04:05
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61K31/472; A61K31/13; A61K31/4725; A61K31/495; A61K31/496; A61K31/55; A61K31/553
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
46 words
A method of treatment of a subject with a stroke in progress to reduce the occurrence of neuronal damage, said method comprising administering to said subject within 6 hours of the onset of the stroke a neuronal cell protecting amount of a protein kinase C inhibitor.
Claim 2
Independent Claim
46 words
A method of treatment of a subject with a stroke in progress to reduce the occurrence of neuronal damage, said method comprising administering to said subject within 6 hours of the onset of the stroke a neuronal cell protecting amount of a protein kinase C inhibitor.
Claim 3
Independent Claim
55 words
A method of treatment of a subject with a stroke in progress to reduce the occurrence of neuronal damage, said method comprising administering to said subject within 6 hours of the onset of the stroke a neuronal cell protecting amount of a protein kinase C inhibitor selected from the group consisting of H-7 and H-8.
Claim 4
Independent Claim
55 words
A method of treatment of a subject with a stroke in progress to reduce the occurrence of neuronal damage, said method comprising administering to said subject within 6 hours of the onset of the stroke a neuronal cell protecting amount of a protein kinase C inhibitor selected from the group consisting of H-7 and H-8.
Claim 5
Dependent Claim
13 words
The method of claim 2 wherein, the administering is via a parenteral route.
Claim 6
Dependent Claim
13 words
The method of claim 3 wherein the protein kinase C inhibitor is H-7.
Claim 7
Dependent Claim
13 words
The method of claim 3 wherein the protein kinase C inhibitor is H-8.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-05-21 | 1999-11-20 | 2000-05-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-05-21 | 2003-11-20 | 2004-05-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-05-21 | 2007-11-20 | 2008-05-21 | $7700.00 | Window Closed / Lapsed |