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US5508342A
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Polymeric amorphous calcium phosphate compositions
Assignee: COMMERCE SECRETARY OF United States, AS REPRESENTED
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Filing: 1994-02-01
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Granted: 1996-04-16
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Expires: 2014-02-01
Abstract
Abstract A mineralizing composition for skeletal tissue comprising a mixture of an unsaturated monomer system, and a particulate mineralizing agent.
Inventors
- 👤 Joseph M. Antonucci
- 👤 Edward D. Eanes
- 👤 Drago Skrtic
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 09:10
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/02; A61L27/12; A61K; A61K6/00; A61K6/60; A61K6/69; A61K6/70; A61K6/71; A61K6/74; A61K6/75; A61K6/76; A61K6/77; A61L27/40; A61L27/44; A61L27/46; C; C08; C08K; C08K3/00; C08K3/32; A61F; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
23 words
A mineralizing composition for skeletal tissue comprising a mixture of an unsaturated monomer system, and a particulate mineralizing agent comprising amorphous calcium phosphate.
Claim 2
Dependent Claim
23 words
A mineralizing composition for skeletal tissue comprising a mixture of an unsaturated monomer system, and a particulate mineralizing agent comprising amorphous calcium phosphate.
Claim 3
Dependent Claim
45 words
A mineralizing composition according to claim 1 wherein said unsaturated monomer system comprises at least one monomer which, upon polymerization, forms a polymer of sufficient permeability to permit slow diffusion of water and mineralizing agent to effect highly crystalline mineralization at a skeletal tissue interface.
Claim 4
Dependent Claim
18 words
A mineralizing composition according to claim 1 wherein said unsaturated monomer system includes at least one cross-linking agent.
Claim 5
Dependent Claim
23 words
A mineralizing composition according to claim 1 wherein said unsaturated monomer system includes at least one monomer, the homopolymer of which is hydrophilic.
Claim 6
Dependent Claim
29 words
A mineralizing composition according to claim 1 wherein said unsaturated monomer system includes at least one monomer, the homopolymer of which is hydrophilic and at least one cross-linking agent.
Claim 7
Dependent Claim
17 words
A mineralizing composition according to claim 2 wherein said at least one monomer includes a methacrylate moiety.
Claim 8
Dependent Claim
18 words
A mineralizing composition according to claim 4 wherein said at least one cross-linking agent comprises a methacrylate moiety.
Claim 9
Dependent Claim
16 words
A mineralizing composition according to claim 1 wherein said unsaturated monomer system includes a free-radical initiator.
Claim 10
Dependent Claim
14 words
A mineralizing composition according to claim 8 wherein said free-radical initiator is a photoinitiator.
Claim 11
Dependent Claim
15 words
A mineralizing composition according to claim 1 wherein said composition further includes a stabilizing agent.
Claim 12
Dependent Claim
14 words
A mineralizing composition according to claim 10 wherein said stabilizing agent includes Mg ions.
Claim 13
Dependent Claim
15 words
A mineralizing composition according to claim 10 wherein said stabilizing agent includes CO 3 ions.
Claim 14
Dependent Claim
17 words
A mineralizing composition according to claim 10 wherein said stabilizing agent includes P 2 O 7 ions.
Claim 15
Dependent Claim
15 words
A mineralizing composition according to claim 1 wherein said unsaturated monomer system includes 2, 2propane.
Claim 16
Dependent Claim
15 words
A mineralizing composition according to claim 1 wherein said unsaturated monomer system includes triethyleneglycol dimethacrylate.
Claim 17
Dependent Claim
15 words
A mineralizing composition according to claim 1 wherein said unsaturated monomer system includes 2-hydroxyethyl methacrylate.
Claim 18
Dependent Claim
15 words
A mineralizing composition according to claim 1 wherein said unsaturated monomer system includes zirconyl dimethacrylate.
Claim 19
Dependent Claim
12 words
A mineralizing composition according to claim 9 wherein said photoinitiator is camphorquinone.
Claim 20
Dependent Claim
12 words
A mineralizing composition according to claim 8 further including a polymerization accelerator.
Claim 21
Dependent Claim
22 words
A mineralizing composite for skeletal tissue comprising an inorganic particulate mineralizing agent which comprises amorphous calcium phosphate incorporated within a polymeric matrix.
Claim 22
Dependent Claim
22 words
A mineralizing composite for skeletal tissue comprising an inorganic particulate mineralizing agent which comprises amorphous calcium phosphate incorporated within a polymeric matrix.
Claim 23
Dependent Claim
24 words
A mineralizing composite according to claim 20 wherein said cross-linked polymeric matrix is of sufficient hydrophilicity to permit diffusion of water and ions therethrough.
Claim 24
Dependent Claim
15 words
A mineralizing composite according to claim 20 wherein said polymeric matrix is a cross-linked matrix.
Claim 25
Dependent Claim
43 words
A mineralizing composition according to claim 1 wherein the mineralizing filler is pretreated or treated in situ in the composite paste with an appropriate surface-active agent selected from the group consisting of silane, titanate, zirconate and aluminate class of compounds or mixtures thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-04-16 | 1999-10-16 | 2000-04-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-04-16 | 2003-10-16 | 2004-04-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-04-16 | 2007-10-16 | 2008-04-16 | $7700.00 | Window Closed / Lapsed |