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US5508267A
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US
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Bioactive material
Assignee: Oxford University Innovation Ltd
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Filing: 1992-10-22
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Granted: 1996-04-16
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Expires: 2012-10-22
Abstract
Abstract A self-supporting composite bioactive material and method of making it, which comprises immersing a body of collagen in a solution comprising a calcium phosphate and a phosphoprotein (preferably containing o-phosphoserine residues) to deposit on the collagen a mineralized layer of calcium phosphate and the phosphoprotein.
Inventors
- 👤 Jan T. Czernuszka
- 👤 Karen I. Clarke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 21:27
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; A61L27/14; A61L27/26; A61L27/30; A61L27/32; A61L27/40; A61L27/44; A61L27/46; C; C08; C08L; C08L89/00; C08L89/04; C08L89/06; A61F; A61F2310/00; A61F2310/00389; A61F2310/00592; A61F2310/00796; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/84
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
29 words
A self supporting composite bioactive material comprising a collagen substrate carrying a layer comprising a phosphoprotein and calcium phosphate deposited from a solution comprising the phosphoprotein and calcium phosphate.
Claim 2
Dependent Claim
29 words
A self supporting composite bioactive material comprising a collagen substrate carrying a layer comprising a phosphoprotein and calcium phosphate deposited from a solution comprising the phosphoprotein and calcium phosphate.
Claim 3
Dependent Claim
18 words
A self supporting composite bioactive material according to claim 1 wherein the phosphoprotein is a bone specific phosphoprotein.
Claim 4
Dependent Claim
20 words
A self supporting composite bioactive material according to claim 1 wherein the calcium phosphate has a Ca/P ratio of 2:1.
Claim 5
Independent Claim
43 words
A method of making a self supporting composite bioactive material which method comprises immersing a body of collagen in a solution comprising calcium phosphate and phosphoprotein for a period sufficient to deposit on the collagen a mineralised layer of calcium phosphate and phosphoprotein.
Claim 6
Independent Claim
43 words
A method of making a self supporting composite bioactive material which method comprises immersing a body of collagen in a solution comprising calcium phosphate and phosphoprotein for a period sufficient to deposit on the collagen a mineralised layer of calcium phosphate and phosphoprotein.
Claim 7
Dependent Claim
14 words
A method according to claim 4 wherein the phosphoprotein is a bone specific phosphoprotein.
Claim 8
Dependent Claim
11 words
A method according to claim 4 wherein the phosphoprotein contains phosphoserine.
Claim 9
Dependent Claim
23 words
A method according to claim 4 wherein the phosphoprotein is present in the solution at a concentration of from 1 to 5 mM.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-04-16 | 1999-10-16 | 2000-04-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-04-16 | 2003-10-16 | 2004-04-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-04-16 | 2007-10-16 | 2008-04-16 | $7700.00 | Window Closed / Lapsed |