Patent US5501856A successfully refreshed from Google Patents.
US5501856A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Controlled-release pharmaceutical preparation for intra-ocular implant
Assignee: Senju Pharmaceutical Co Ltd
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Filing: 1991-11-27
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Granted: 1996-03-26
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Expires: 2011-11-27
Abstract
Abstract Presented are a controlled-release pharmaceutical preparation for intra-ocular implant to be applied to the interior of the eye after a surgical operation for disorders in retina/vitreous body or for glaucoma, which is produced by homogeneously dispersing an anti-inflammatory agent or a cell proliferation antagonist in certain polylactic acid and forming it into a particular shape; and a method for the prevention of the recurrence of said disorders or glaucoma after a surgical operation therefor.
Inventors
- 👤 Akira Ohtori
- 👤 Masako Andoh
- 👤 Yasushi Morita
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 16:02
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0048; A61K9/0051; A61F; A61F9/00; A61F9/0008; A61F9/0017; A61K47/00; A61K47/30; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204; A61P; A61P27/00; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P43/00; Y; Y10; Y10S; Y10S623/00; Y10S623/902; Y10S623/905
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
144 words
A method for the prevention of the recurrence of proliferative vitreoretinopathy or of glaucoma after a surgical operation for the treatment thereof comprising placing in the interior of the operated eye a controlled-release pharmaceutical preparation in the shape of a stick, needle or film adapted for introduction into the vitreous cavity as an intraocular implant and produced by (a) homogeneously dispersing as an active agent therein at least one anti-inflammatory steroid or one cell proliferation antagonist in a polylactic acid with a number-average molecular weight of about 2,000 to about 4,000 or with a number-average molecular weight of about 5,000 to about 7,000, or a mixture thereof, and (b) forming the dispersion of anti-inflammatory steroid or one cell proliferation antagonist in the polylactic acid into the shape of a stick, needle or film adapted for introduction into the vitreous cavity as an intra-ocular implant.
Claim 2
Independent Claim
144 words
A method for the prevention of the recurrence of proliferative vitreoretinopathy or of glaucoma after a surgical operation for the treatment thereof comprising placing in the interior of the operated eye a controlled-release pharmaceutical preparation in the shape of a stick, needle or film adapted for introduction into the vitreous cavity as an intraocular implant and produced by (a) homogeneously dispersing as an active agent therein at least one anti-inflammatory steroid or one cell proliferation antagonist in a polylactic acid with a number-average molecular weight of about 2,000 to about 4,000 or with a number-average molecular weight of about 5,000 to about 7,000, or a mixture thereof, and (b) forming the dispersion of anti-inflammatory steroid or one cell proliferation antagonist in the polylactic acid into the shape of a stick, needle or film adapted for introduction into the vitreous cavity as an intra-ocular implant.
Claim 3
Dependent Claim
18 words
The method of claim 1, wherein said anti-inflammatory steroid is dexamethasone m-sulfobenzoate sodium salt, hydrocortisone acetate or fluoromethalone.
Claim 4
Dependent Claim
15 words
The method of claim 1, wherein said cell proliferation antagonist is a pyrimidine metabolism antagonist.
Claim 5
Dependent Claim
12 words
The method of claim 3, wherein said pyrimidine metabolism antagonist is 5-fluorouracil.
Claim 6
Dependent Claim
17 words
A method according to claim 1, wherein the pharmaceutical preparation is in the form of a film.
Claim 7
Dependent Claim
18 words
A method according to claim 1, wherein the pharmaceutical preparation is in the form of a short stick.
References Cited (Backward Citations)
US4142526A
Cited
US4853224A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-03-26 | 1999-09-25 | 2000-03-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-03-26 | 2003-09-25 | 2004-03-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-03-26 | 2007-09-25 | 2008-03-26 | $7700.00 | Window Closed / Lapsed |